Carmen Costache

ORCID: 0000-0003-2640-0072
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About
Contact & Profiles
Research Areas
  • Parasitic Infections and Diagnostics
  • Bacterial biofilms and quorum sensing
  • Toxoplasma gondii Research Studies
  • Bacterial Identification and Susceptibility Testing
  • Amoebic Infections and Treatments
  • Antifungal resistance and susceptibility
  • Antibiotic Resistance in Bacteria
  • Fungal Infections and Studies
  • Antimicrobial Resistance in Staphylococcus
  • Genomics and Phylogenetic Studies
  • Cytomegalovirus and herpesvirus research
  • Bacteriophages and microbial interactions
  • Antibiotic Use and Resistance
  • Parasite Biology and Host Interactions
  • Parasitic Diseases Research and Treatment
  • Microfluidic and Bio-sensing Technologies
  • Parasitic infections in humans and animals
  • Plant Pathogens and Fungal Diseases
  • Parvovirus B19 Infection Studies
  • Nail Diseases and Treatments
  • Infective Endocarditis Diagnosis and Management
  • Microbial infections and disease research
  • Dental Radiography and Imaging
  • Oral microbiology and periodontitis research
  • Dental Implant Techniques and Outcomes

Spitalul Clinic Județean de Urgență Cluj-Napoca
2021-2025

Iuliu Hațieganu University of Medicine and Pharmacy
2013-2025

Sleep deprivation is highly prevalent in the modern world, possibly reaching epidemic proportions. While multiple theories regarding roles of sleep exist (inactivity, energy conservation, restoration, brain plasticity and antioxidant), unknowns still remain proposed antioxidant sleep. The existing experimental evidence often contradicting, with studies pointing both toward against presence oxidative stress after deprivation. main goals this review were to analyze data relationship between...

10.3390/antiox12081600 article EN cc-by Antioxidants 2023-08-11

Background andobjectives: Health systems all over the world are confronted with an alarming rise of cases in which individuals hesitate, delay, and even refuse vaccination, despite availability quality vaccine services. In order to mitigate combat this phenomenon, now defined by World Organization (WHO) as hesitancy (VH), we must first understand factors that lead its occurrence era characterized wide access safe effective vaccines. To achieve this, conducted field testing Vaccine Hesitancy...

10.3390/medicina55060282 article EN cc-by Medicina 2019-06-17

(1) Background: This paper aims to provide a description of non-faecalis non-faecium enterococci isolated from tertiary care hospital in Romania and briefly review the existing literature regarding involvement Enterococcus raffinosus, durans avium human infections their antimicrobial resistance patterns; (2) Methods: We retrospectively analyzed all Enteroccocus species “Prof. Dr. O. Fodor” Regional Institute Gastroenterology Hepatology Cluj-Napoca during one year focusing on Enterococci. A...

10.3390/biology11040598 article EN cc-by Biology 2022-04-14

Antibiotic resistance is on the WHO's top 10 list of global public health threats due to its rapid emergence and spread but also because high morbidity mortality associated with it. Amongst main species driving this phenomenon A. baumannii, a member ESKAPE group medical assistance-associated infections causing famous for extensively drug-resistant phenotypes. Our findings note 91.52% frequency carbapenem-resistant baumannii (XDR CRAB) phenotype amongst clinical isolates from multiple...

10.3390/microorganisms13010176 article EN cc-by Microorganisms 2025-01-16

Background/Objectives: With the increasing use of dental implants in edentulous patients and high prevalence peri-implantitis, understanding its microbial risk factors is crucial. This study investigated Romanian from two private clinics Cluj-Napoca, Romania, diagnosed with focusing on identifying predominant bacterial species at affected sites compared healthy implant sites. Additionally, we examined impact such as smoking, gender, age, prosthetic restoration type disease prevalence....

10.3390/dj13040148 article EN cc-by Dentistry Journal 2025-03-28

(1) Background: As β-lactamase-producing Enterobacterales are no longer exclusively associated with the health care system, investigating potential risk they pose to integrity of environment and food safety has become utmost importance. This study aimed determine prevalence extended-spectrum β-lactamase (ESBL), AmpC, carbapenemase-producing isolates from retailed raw vegetables if household washing is an effective method lowering bacterial load; (2) Methods: Seasonal (n = 165) were acquired...

10.3390/foods9121726 article EN cc-by Foods 2020-11-24

COVID-19 offers ideal premises for bacteria to develop antimicrobial resistance. In this study, we evaluated the presence of several resistance genes (ARG) in vancomycin-resistant Enterococcus (VRE) isolated from rectal swabs patients at a hospital Cluj-Napoca, Romania. Rectal were cultivated on CHROMID® VRE (bioMérieux, Marcy-l' Étoile, France) and positive isolates identified using MALDI-TOF Mass Spectrometry (Bruker Daltonics, Bremen, Germany) further analyzed PCR technique following...

10.3390/biomedicines10051122 article EN cc-by Biomedicines 2022-05-12

is a rare species, part of the viridans streptococcus group, found initially in rabbits and pigs, which can be vancomycin-resistant. We present case 65-year-old patient, smoker chronic alcohol consumer with obstructive pulmonary disease (COPD) multiple dental foci who had been diagnosed bacterial endocarditis caused by

10.3390/microorganisms12030566 article EN cc-by Microorganisms 2024-03-12

(1) Background: The rise in antibiotic resistant bacteria poses a significant threat to public health worldwide, necessitating innovative solutions. This study explores the role of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) context resistance among different species from

10.3390/biomedicines12071625 article EN cc-by Biomedicines 2024-07-22

Abstract Background Giardia duodenalis is one of the most prevalent and highly diverse human parasites, encompassing a complex eight genetically distinct assemblages, each further divided into sub-assemblages. While in recent years, G. genotype distribution patterns humans have been intensely studied, there still very little information available on diversity genotypes sub-assemblages infecting people Romania. In present study, we investigated genetic asymptomatic patients from Methods Over...

10.1186/s13071-020-04248-2 article EN cc-by Parasites & Vectors 2020-07-31

Very limited data exists on the genetic diversity of Toxoplasma gondii from Eastern Europe. We present first Romanian case symptomatic congenital toxoplasmosis in which T. strain was isolated after inoculation mice a cerebrospinal fluid sample living neonate. The genotyped with 15 microsatellite markers distributed 10 14 chromosomes gondii. had type II genotype.

10.1051/parasite/2013011 article EN cc-by Parasite 2013-01-01

Dermatophytes are filamentous keratinophilic fungi which affect nails, skin, and hair. Their variable distribution in the world justifies local epidemiological studies. During recent decades, few studies have been published regarding epidemiology etiology of dermatophytosis Romania. The aim this study was to identify dermatophytes isolated from superficial fungal infections. To best our knowledge, is first such conducted area North-Western Over past four years, samples collected outpatients...

10.3390/jof6030154 article EN cc-by Journal of Fungi 2020-08-28

An often-overlooked side of the population aging process and steady rise non-communicable diseases reflects emergence novel infectious pathogens on background an altered host immune response. The aim this article was to present first record a ciliate flagellate protozoa recovered from urine elderly patient review existing medical literature involving these parasites. A 70-year-old female admitted for breathing difficulties basis acute exacerbation COPD (Chronic obstructive pulmonary disease)...

10.3390/biology10060476 article EN cc-by Biology 2021-05-27

This study aimed to evaluate the antibacterial effect of three final irrigation protocols and compare their ability remove smear layer debris from root canal. Methods: Sixty-three single-rooted human teeth were inoculated with Enterococcus faecalis for 14 days. The divided into a positive control group (N = 3) treatment groups 20) as follows: saline solution (control group), 5.25% NaOCl ultrasonically activated EndoUltra (EU), standard needle Qmix 2in1 (Qx) using SiroLaser Blue (SB)....

10.3390/ma15196688 article EN Materials 2022-09-27

Background: Bacterial biofilm formation (BBF) proves itself to be in the spotlight of microbiology research due wide variety infections that it can associated with, involvement food spoilage, industrial biofouling and perhaps sewage treatment. However, BBF remains difficult study lack standardization existing methods expensive equipment needed. We aim describe a new inexpensive easy reproduce protocol for 3D-printed microfluidic device used dynamic manner. Methods: SolidWorks 3D CAD Software...

10.3390/cells11244119 article EN cc-by Cells 2022-12-19

The SARS-CoV-2 pandemic has proved to be a significant risk addition for invasive infections with Aspergillus. Even though there are plenty of data about the COVID-19-associated pulmonary aspergillosis (CAPA), especially involving Aspergillus fumigatus, recent studies presenting cases CAPA more than one species We report first case patient associating co-infection with, most likely, section Fumigati and Flavi from Romania, we review existing medical literature in order shed light upon mixed...

10.3390/jof7100877 article EN cc-by Journal of Fungi 2021-10-18

Although the COVID-19 pandemic has held spotlight over past years, antimicrobial resistance (AMR) phenomenon continues to develop in an alarming manner. The lack of strict antibiotic regulation added overuse antimicrobials fueled AMR pandemic. This paper aims analyze and identify impact on patterns Enterococcus spp. study was designed as a retrospective observational study. infections data were collected from one academic hospital Cluj-Napoca, Romania 18 months. A statistical analysis...

10.3390/antibiotics12020312 article EN cc-by Antibiotics 2023-02-02
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