A5007070631- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Dermatology and Skin Diseases
- Vitamin D Research Studies
- Urticaria and Related Conditions
- Drug-Induced Adverse Reactions
- Nigella sativa pharmacological applications
- Phytochemicals and Antioxidant Activities
- Respiratory and Cough-Related Research
- Pharmacological Effects of Natural Compounds
- Bioactive Compounds and Antitumor Agents
- Curcumin's Biomedical Applications
- Pharmacological Effects and Toxicity Studies
- Respiratory viral infections research
- Gut microbiota and health
- Antioxidant Activity and Oxidative Stress
- Liver Disease Diagnosis and Treatment
- Treatment of Major Depression
- Eosinophilic Esophagitis
- COVID-19 Clinical Research Studies
- Blood Pressure and Hypertension Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmacogenetics and Drug Metabolism
- Probiotics and Fermented Foods
Iuliu Hațieganu University of Medicine and Pharmacy
2016-2025
University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
2018-2024
Curcumin has anti-inflammatory, antioxidative, anticarcinogenic, and cardiovascular protective effects. Our study is aimed at evaluating the effects of pretreatment with curcumin nanoparticles (CCNP) compared to conventional (CC) on isoproterenol (ISO) induced myocardial infarction (MI) in rats. Fifty-six Wistar-Bratislava white rats were randomly divided into eight groups seven each. given by gavage three different doses (100 mg/kg body weight (bw), 150 bw, 200 bw) for 15 days. The MI was...
Curcumin from Curcuma longa is a nutraceutical compound reported to possess strong antioxidant activity that makes it candidate for use in counteracting oxidative stress-induced damage. The effect of pre-treatment with curcumin nanoparticles (nC) compared conventional (Cs) on blood pressure, electrocardiogram, and biological changes isoproterenol (ISO)-induced myocardial infarction (MI) rats had been investigated. Cs doses 150 200 mg/kg bw all nC (100, bw) significantly reduced heart rate...
Acetaminophen (APAP) is one of the most used analgesics and antipyretic agents in world. Intoxication with APAP main cause acute liver toxicity both US Europe. Spore-forming probiotic bacteria have ability to resist harsh gastric intestinal conditions. The aim this study was investigate possible protective effect Bacillus (B) species (sp) spores (B. licheniformis, B. indicus, subtilis, clausii, coagulans) against hepatotoxicity induced by rats. A total 35 rats were randomly divided into...
The aim of the present study was to establish prevalence sleep/awake bruxism among young students in Transylvania and correlate presence this muscle activity with behavioral variations. This analytical, observational, cohort, cross-sectional, prospective involved 308 volunteers aged between 19 30 years different nationalities, all "Iuliu Hațieganu" University Medicine Pharmacy Cluj-Napoca, Romania. Subjects were asked complete an anonymous questionnaire which structured five sections....
The present study aims to compare the oxidative stress biomarkers, pro-inflammatory cytokines, and histological changes induced by three cardiovascular risk factors, namely, hypertension, dyslipidemia, type 1 diabetes mellitus. Hypertension was with 40 mg/kg body weight (b.w.) of N omega-nitro-L-arginine-methyl (L-NAME) administered orally. Dyslipidemia administration a diet high cholesterol (2%) content. Diabetes mellitus intraperitoneal single dose streptozocin (65 mg/kg). Malondialdehyde...
Trametes species represents a rich source of nutritive compounds with important pharmacological properties like antioxidant, antiinflammatory and anti-cancer properties. However, factors genetic background, harvesting period, geographic location, climatic conditions others are influencing the biosynthesis bioactive compounds, their fingerprint concentration. The aim this study was to determine antioxidant capacity, total phenolic flavonoids content two mushroom species, namely Tramestes...
Nigella sativa (NS) has been used for centuries in various inflammatory conditions because of its anti-inflammatory and antioxidant activities. The study aimed to evaluate the anti-inflammatory, antinociceptive activity oil (NSO) two models acute (carrageenan-induced) sub-acute inflammation (complete Freund’s adjuvant induced) rats. Materials Methods: NSO was administered orally 1, 2 4 mL/kg phase. For subacute phase, mL/kg, 7 days before or after induction, association with diclofenac 5...
(1) Background: The COVID-19 pandemic has resulted in the exacerbation of various chronic diseases. Due to potential impact SARS-CoV-2 on mast cells, we aimed analyze relevance disease spontaneous urticaria (CSU) clinical presentation and biological profile. (2) Methods: This study is a retrospective case series patients with CSU diagnosed treated Allergy Department Professor Doctor Octavian Fodor RIGH, (Cluj-Napoca, Romania). Patients were assessed for activity level control weekly score...
The present study evaluated the anti-inflammatory and analgesic effects of conventional curcumin (cC) nanoparticles (nC) associated with diclofenac sodium (D) in experimental acute inflammation (AI) induced by carrageenan administration. Seven groups eight randomly selected Wistar-Bratislava white rats were evaluated. One group was control (C), AI other six groups. treated saline solution, AID D, AIcC200 AInC200 cC nC, respectively, while AIcC200D AInC200D both D. Conventional curcumin, D...
A growing interest in using Nigella sativa oil (NSO) the prevention or treatment of several cardiovascular diseases has prompted this study. The research aims to investigate effect NSO on cardiac damage after long-term administration induced myocardial infarction (MI) rats.
The prevalence of food allergy (FA) varies worldwide with an increasing rate in the last decades. Data self-reported FA have been recorded by most European countries, US, Canada and Australia, but not Romania. aim this study is to analyze severity assess extent information medical teaching staff schools on students’ history. Methods A cross-sectional survey was performed schoolchildren from Cluj-Napoca, Romania, using online questionnaire delivered their parents. Results conclusions Seven...
Grape pomace (GP), the residue left after grape pressing in winemaking, is rich polyphenols, including flavonoids, tannins, and phenolic acids, which have antioxidant anti-inflammatory properties. The present study aimed to evaluate cardioprotective effects of white (WGP) extract two concentrations polyphenols (795 mg from WGP/kg body weight (bw) 397.5 bw)), on isoproterenol (ISO)-induced myocardial infarction (MI), focusing its effects. White administration for 14 days offered a...
Glucocorticoids are steroid hormones used in clinical practice as an effective therapeutic option for their effects regarding the dysregulated immune reactions and hyperactive system. Their administration short- long-term exposure has been associated with numerous metabolic side effects. Probiotics have shown to modulate basal metabolism, inflammation, oxidative stress through regulation of composition function gut microbial environment. The aim this study was assess Saccharomyces boulardii...
Background Nowadays, growing attention was being given to the alternative ways prevent or treat diseases. Nutraceuticals are used increasingly for this purpose. Many of these as therapy. Classic therapy with synthetic drugs, although very effective, has many side effects. The term “nutraceuticals” refers link between nutritional and pharmaceutical domains. Also, lately, studies have been done investigate role microbiota in maintaining health. There is hypothesis that some health benefits...
NASH consists in lipid accumulation hepatocytes that trigger oxidative stress, secretion of proinflammatory cytokines leading to steatohepatitis (NASH). The study aimed investigate the levels (TNF‐ α and IL‐6) along with anti‐inflammatory cytokine IL‐10 patients correlate cytokines’ level their polymorphism. Sixty‐six 30 healthy volunteers were included study. plasmatic IL‐6, IL‐10, TNF‐ determined by ELISA. ‐1082 G/A, IL‐6 ‐174 G/C, ‐308 G/A polymorphisms using PCR‐RFLP technique. , CRP...