A5085196381- Bone Tissue Engineering Materials
- Dental materials and restorations
- Dental Implant Techniques and Outcomes
- Graphene and Nanomaterials Applications
- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- Orthopaedic implants and arthroplasty
- Crystallization and Solubility Studies
- Thermal and Kinetic Analysis
- Conducting polymers and applications
- Coagulation and Flocculation Studies
- Catalytic Processes in Materials Science
- Minerals Flotation and Separation Techniques
- Periodontal Regeneration and Treatments
- Oral microbiology and periodontitis research
- Advanced Sensor and Energy Harvesting Materials
- Extraction and Separation Processes
- Advanced ceramic materials synthesis
- X-ray Diffraction in Crystallography
- Additive Manufacturing Materials and Processes
- Crystallography and molecular interactions
- Recycling and Waste Management Techniques
- Phytochemicals and Antioxidant Activities
- Inflammasome and immune disorders
- Oral and gingival health research
Babeș-Bolyai University
2015-2024
TU Bergakademie Freiberg
2006
The present study aimed to prepare nanofibers by electrospinning in the system polylactic acid-hydroxyapatite-doxycycline (PLA-HAP-Doxy) be used as a drug delivery vehicle. Two different routes were employed for preparation of Doxy-containing nanofibers: Immobilization on electrospun mat's surface and encapsulation fiber structure. obtained Doxy characterized using Fourier transform infrared (FTIR) spectroscopy, thermogravimetric (TG) differential thermal analyses (DTA) scanning electron...
Mucoadhesive films loaded with doxycycline hyclate (Doxy Hyc), consisting of mixtures hydroxypropylmethyl cellulose (HPMC) E3, K4 and polyacrylic acid (Carbopol 940), were prepared by casting method, aiming to design a formulation intended for application in the oral cavity. The obtained film formulations exhibited Doxy Hyc content between 7.52 ± 0.42 7.83 0.41%, which had adequate mechanical properties cavity pH values tolerance range. x-ray diffraction studies highlighted amorphisation...
The immunomodulatory effect of a novel biomaterial obtained through electrospinning, based on polylactic acid (PLA) and nano-hydroxyapatite (nano-HAP), loaded with doxycycline (doxy) was evaluated in an animal model. treatment capabilities as local non-surgical periodontitis investigated the lower incisors Wistar rats, after induction localized using ligature technique. Following disease, scaling root planing applied, conjunction application new material. results were clinically, tooth...
This review aimed at searching literature for data regarding the inflammasomes’ involvement in pathogenesis of oral diseases (mainly periodontitis) and general pathologies, including approaches to control inflammasome-related pathogenic mechanisms. The inflammasomes are part innate immune response that activates inflammatory caspases by canonical noncanonical pathways, activity Gasdermin D. Once an inflammasome is activated, pro-inflammatory cytokines, such as interleukins, released. Thus,...
Abstract Hydroxyapatite composites are the main biomaterials used for metal implant coatings. Their in vitro study is very important. That why their behavior was monitored simulated body fluid (SBF), which a solution with ion concentrations and pH value similar to those of human blood plasma. Silica, chitosan gelatin-doped hydroxyapatite-based were studied SBF; samples characterized pre-, during post-SBF immersion using infra-red, scanning transmission electron spectroscopy X-ray diffraction...
In the present work, ZrO2-based composites were prepared by adding different amounts of antibacterial magnesium oxide and bioactive biocompatible hydroxyapatite (HAP) to inert zirconia. The synthesized conventional ceramic processing route morpho-structurally analyzed X-ray powder diffraction (XRPD) scanning electron microscopy/energy dispersive spectroscopy (SEM/EDS). Two metallic dental alloys (i.e., Ni–Cr Co–Cr) coated with a chitosan (Chit) membrane containing exposed aerated artificial...
The present study aimed to assess the in vitro antimicrobial effects of a novel biomaterial containing polylactic acid (PLA), nano-hydroxyapatite (nano-HAP) and Doxycycline (Doxy) obtained by electrospinning designed for non-surgical periodontal treatment. activity two samples (test sample, PLA-HAP-Doxy7: 5% PLA, nano-HAP, 7% Doxy control PLA-HAP: nano-HAP) against pathogens—Aggregatibacter actinomycetemcomitans Porphyromonas gingivalis—was assessed using Kirby–Bauer Disk Diffusion...
Abstract The utilization of computers in all aspects and scales chemical engineering, from fundamental understanding to solution large‐scale optimizations, is spreading quickly, hand‐in‐hand with access data science information technology. It straightforward involve virtual laboratory tools into engineering education. This study presents the development an interactive method for a continuous binary distillation process. three main steps, namely, mathematical modeling, model calibration,...
Background: SLM (Selective Laser Melting)–manufactured Titanium (Ti) scaffolds have a significant value for bone reconstructions in the oral and maxillofacial surgery field. While their mechanical properties biocompatibility been analysed, there is still no adequate information regarding tissue integration. Therefore, aim of this study comprehensive systematic assessment essential parameters (porosity, pore dimension, surface treatment, shape) required to provide long-term performance Ti...
Electrospun mats of PLA and PLA/Hap nanofibers produced by electrospinning were loaded with doxycycline (Doxy) through physical adsorption from a solution initial concentrations 3 g/L, 7 12 respectively. The morphological characterization the material was performed using scanning electron microscopy (SEM). release profiles Doxy studied in situ differential pulse voltammetry (DPV) electrochemical method on glassy carbon electrode (GCE) validated UV-VIS spectrophotometric measurements. DPV has...
The aim of this review was to search in literature, data regarding the inflammasome, involvement in, oral pathologies (mainly periodontitis) and other diseases approaches control inflammasome-related pathogenic mechanisms. also investigated how phytochemicals pharmaceutical substances could be used inhibit inflammasome activity. Inflammasomes are involved inflammatory, autoimmune autoinflammatory diseases. Pharmaceutical can by three mechanisms: inhibiting intracellular signaling pathways...
Abstract In the present paper, hydroxyapatite and structurally modified were investigated to establish best material for nicotinic acid adsorption. Structurally wa prepared by adding sodium silicate in reaction medium. The influence of silica concentration, presence small amounts metal ions, temperature initial concentrations solutions on adsorption capacity, studied. Results indicated that doped with copper adsorbed highest amount acid. For this capacity was 0.232 mg / g material, at an...