A5058468216- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Cell Image Analysis Techniques
- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- DNA Repair Mechanisms
- Gastric Cancer Management and Outcomes
- AI in cancer detection
- Chronic Myeloid Leukemia Treatments
- Optimism, Hope, and Well-being
- Histiocytic Disorders and Treatments
- Fibroblast Growth Factor Research
- Immunodeficiency and Autoimmune Disorders
- Gene expression and cancer classification
- Chronic Lymphocytic Leukemia Research
- Prostate Cancer Treatment and Research
- Genetic Neurodegenerative Diseases
- Genetic factors in colorectal cancer
- Pulmonary Hypertension Research and Treatments
- Biomarkers in Disease Mechanisms
- RNA modifications and cancer
Goethe University Frankfurt
2013-2024
University Hospital Frankfurt
2015-2024
Senckenberg Research Institute and Natural History Museum Frankfurt/M
2016-2018
We aimed to identify hepatocellular carcinoma (HCC) patients who will respond repetitive transarterial chemoembolization (TACE) improve the treatment algorithm. Retrospectively, 61 (mean age, 65.3 years ± 10.0 [SD]; 49 men) with 94 HCC mRECIST target-lesions had three consecutive TACE between 01/2012 and 01/2020 were included. Robust non-redundant radiomics features extracted from 24 h post-embolization CT. Five different clinical TACE-scores assessed. Seven feature selection methods machine...
In gastric cancer (GC), there are four molecular subclasses that indicate whether patients respond to chemotherapy or immunotherapy, according the TCGA. clinical practice, however, not every patient undergoes testing. Many laboratories have used well-implemented in situ techniques (IHC and EBER-ISH) determine their cohorts. Although multiple stains used, we show a staining approach is unable correctly discriminate all subclasses. As an alternative, trained ensemble convolutional neuronal...
Background and objectiveWith European Medicines Agency approval of PARP inhibitors in metastatic castration-resistant prostate cancer ongoing trials hormone-sensitive cancer, detection genetic alterations BRCA1/2 other homologous recombination repair genes has gained an important role. Our aim was to investigate the feasibility comparability comprehensive next-generation sequencing (NGS) liquid biopsy (LB; circulating tumor DNA) tissue (TT) samples a real-world clinical setting.MethodsThe...
Background: Protective effects of vitamin D have been reported in autoimmune and malignant thyroid diseases, though little is known about the underlying mechanism. Sirtuin 1 histon deacethylase (SIRT1) links pathway with regulation transcription factor FOXO3a, a key player cell cycle apoptosis. Aim present study was to investigate common single nucleotide polymorphisms (SNP's) FOXO3a gene respect as well evaluate hypothesis Sirtuin1-FOXO3a interaction being mediator anti-proliferative...
The autosomal recessive disorder Ataxia-Telangiectasia is caused by a dysfunction of the stress response protein, ATM. In nucleus proliferating cells, ATM senses DNA double-strand breaks and coordinates their repair. This role explains T-cell tumour risk. However, it remains unclear whether this function relevant for postmitotic neurons underlies cerebellar atrophy, since cytoplasmic in neurons. Here, we used ATM-null mice that survived early immune deficits via bone-marrow transplantation,...
The autosomal recessive disorder Ataxia-Telangiectasia is caused by dysfunction of the stress response protein ATM. In nucleus proliferating cells, ATM senses DNA double-strand breaks and coordinates their repair. This role explains T-cell tumor risk. However, it remains unclear whether this function relevant for postmitotic neurons underlies cerebellar atrophy, since cytoplasmic in neurons. Here, we used ATM-null mice that survived early immune deficits bone-marrow transplantation, reached...
Abstract Tumors derived from histiocytes and follicular dendritic cells (FDC) are extremely rare, constituting less than 1% of hematopoietic tumors. Among others, cell sarcoma (FDC-S), histiocytic (HS) , Langerhans histiocytosis (LH) the commonest types. The clinical course is variable indolent to aggressive; however, disease more often incurable. Further, probably due their rarity complexity, pathobiology these tumor nearly unknown at present, with only scattered studies being reported. In...
Abstract Motivation Hodgkin lymphoma is a tumor of the lymphatic system and represents one most frequent in Western world. It characterized by cells Reed-Sternberg cells, which exhibit broad morphological spectrum. The are visualized immunohistochemical staining tissue sections. In pathology, images mainly manually evaluated, relying on expertise experience pathologists. Computational quantification methods become more essential to evaluate images. particular, distribution cancer great...