A5091331097- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Medical Practices and Rehabilitation
- Ear Surgery and Otitis Media
- Noise Effects and Management
- Ear and Head Tumors
- Sinusitis and nasal conditions
- Head and Neck Cancer Studies
- Facial Nerve Paralysis Treatment and Research
- Vestibular and auditory disorders
- Neuroscience and Neural Engineering
- Speech and Audio Processing
- Head and Neck Surgical Oncology
- Dysphagia Assessment and Management
- Salivary Gland Tumors Diagnosis and Treatment
- Voice and Speech Disorders
- COVID-19 and healthcare impacts
- Nerve injury and regeneration
- Neurofibromatosis and Schwannoma Cases
- Meningioma and schwannoma management
- Hearing Impairment and Communication
- Tracheal and airway disorders
- Adrenal and Paraganglionic Tumors
- Ultrasonics and Acoustic Wave Propagation
- Advanced MRI Techniques and Applications
University Hospital Frankfurt
2016-2025
Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde
2015-2025
Goethe University Frankfurt
2016-2025
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde
2025
Universitäts-HNO-Klinik Heidelberg
2018-2023
Medical University of Vienna
2018-2023
Klinikum Frankfurt Höchst
2022
Verband der Privaten Krankenversicherung
2021
Charité - Universitätsmedizin Berlin
2021
Medizinische Hochschule Hannover
2005-2020
Multiple genes and their variants that lend susceptibility to many diseases will play a major role in clinical routine. Genetics-based cost reduction strategies diagnostic processes are important the setting of multiple for single disease. Head neck paraganglioma (HNP) is caused by germline mutations at least three succinate dehydrogenase subunit (SDHx). Mutation analysis all 3 costs approximately US$2,700 per patient. Genetic classification essential downstream management patient preemptive...
Patients with high-frequency deafness and/or substantial residual hearing across frequencies might benefit from combined electro-acoustic stimulation. The Hybrid-L electrode was designed to address the issues of both conservation and effective electrical stimulation in those recipients. 22 contacts should be inserted through round window membrane, covers approximately 270° basal turn cochlear. This insertion length is equivalent one seen many patients using former Nucleus straight electrode....
Objective of the present experimental research study was to examine hypothesis that cochlear implant insertion speed can significantly affect forces.Cochlear electrode forces influence trauma and preservation residual hearing. The effect on still remains unknown.Force measurements were performed while inserting human electrodes in an artificial scala tympani model at different speeds. For these measurements, Instron 5542 Force Measurement System with a 10 N load cell Nucleus 24 Contour...
<b><i>Aims:</i></b> The Nucleus CI532 cochlear implant incorporates a new precurved electrode array, i.e., the Slim Modiolar (SME), which is designed to bring contacts close medial wall of cochlea while avoiding trauma due scalar dislocation or contact with lateral during insertion. primary aim this prospective study was determine final position array in clinical cases as evaluated using flat-panel volume computed tomography....
Due to improved technology, cochlear implant (CI) candidacy has been widened towards patients with usable residual hearing in the low frequency range. These might benefit from additional acoustic amplification provided that can be preserved implantation. To provide a high probability of preservation, new electrode array was designed and developed at Medizinische Hochschule Hannover. This 'Hybrid-L' 22 electrodes spread over 15 mm an overall insertion depth 16 mm. The straight modiolus facing...
<i>Introduction:</i> Preservation of residual hearing in cochlear implant recipients has been demonstrated to be possible and provides the potential benefit combined electric acoustic auditory stimulation. A prototype 16-mm multichannel array designed facilitate placement 22 electrodes without damage intracochlear structures. The electrode is suitable for insertion via round window membrane (RWM) or a small cochleostomy. <i>Aim:</i> To evaluate trajectory presence...
Abstract As with other cranial nerves and many CNS neurons, primary auditory neurons degenerate as a consequence of loss input from their target cells, the inner hair cells (IHCs). Electrical stimulation (ES) spiral ganglion (SGCs) has been shown to enhance survival. Glial cell line‐derived neurotrophic factor (GDNF) also increase survival SGCs following IHC loss. In this study, combined effects GDNF transgene delivered by adenoviral vectors (Ad‐ ) ES were tested on after first eliminating...
Today, cochlear implantation is the treatment of choice in case severe to profound hearing loss, but speech perception abilities many recipients noisy conditions are still poor and overall sound quality ease listening require improvement. Residual low-frequency has been associated with improved performance implant patients, especially difficult environments (i.e. cocktail party effect). It seems that information can enhance segregation competing voices, which leads better understanding...
This study reviewed outcomes of hearing preservation (HP) surgery in a cochlear implant patient population, with clinical follow-up results up to 11 years after implantation.Retrospective case review.Tertiary referral university hospital.Ninety six patients (103 ears) partial deafness who underwent HP at the University Hospital Frankfurt since 1999 were included. Electrode carriers Cochlear Slim Straight, MED-EL Standard, Medium, Flex, and Flex.Cochlear implantation using technique either...
BackgroundPatient Blood Management (PBM) is a patient-centred, systematic, evidence-based approach to improve patient outcomes by managing and preserving patient's own blood whilst promoting safety empowerment. The effectiveness of PBM over longer period have not yet been investigated.MethodsWe performed prospectively designed, multicentre follow-up study with non-inferiority design. Data were retrospectively extracted case-based from electronic hospital information systems. All in-hospital...
<h3>Objective</h3> The β<sub>2</sub>-transferrin assay is a specific method to identify cerebrospinal fluid (CSF). Hitherto, this test has not been widely used for the routine screening of patients with suspected CSF leakage. purpose study was investigate clinical relevance identification by comparing results other diagnostic measures and intraoperative findings. <h3>Design</h3> Case series. <h3>Patients</h3> Retrospective analysis 182 tested once or multiple times β<sub>2</sub>-transferrin....
The objective of this study was to investigate the long-term effect intraoperative application steroid suspension and coating electrode contacts with a thin film iridium oxide on intracochlear impedance development after cochlear implantation difference before stimulation.Time-dependent impedances investigated in 4 different groups adult patients up years implantation. Additionally, during rehabilitation period just first fitting, stimulation were measured as influence electrical impedances....
Multi-centre collaborative study to develop and refine the design of a prototype thin perimodiolar cochlear implant electrode array assess feasibility for use in human subjects.Multi-centre temporal bone insertion studies.The modiolar research (MRA) is pre-curved that held straight initial with an external sheath rather than internal stylet. Between November 2006 February 2009, six iterations were studied 21 separate studies which 140 insertions performed 85 bones by 12 surgeons. These aimed...
Glial cell line-derived neurotrophic factor (GDNF) overexpression in the inner ear can protect hair cells against degeneration induced by aminoglycoside ototoxicity. The protective efficiency of GDNF increases when it is combined with co-factors such as transforming growth β1 (TGF-β1), a ubiquitous cytokine. aim this study was to determine whether TGF-β1 receptors are expressed and cocktail transgenes provides enhanced protection ototoxic trauma. Using RT-PCR analysis, we determined that...
Electrical stimulation (ES) of spiral ganglion cells (SGC) via a cochlear implant is the standard treatment for profound sensor neural hearing loss. However, loss hair as morphological correlate leads to deafferentation and death SGC. Although immediate with ES or glial cell line-derived neurotrophic factor (GDNF) can prevent degeneration SGC, only few studies address effectiveness delayed treatment. We hypothesize that both interventions have synergistic effect even would protect Therefore,...
Fibrous tissue growth and loss of residual hearing after cochlear implantation can be reduced by application the glucocorticoid dexamethasone-21-phosphate-disodium-salt (DEX). To date, sustained delivery this agent to cochlea using a number pharmaceutical technologies has not been entirely successful. In study we examine novel way continuous local drug into inner ear refillable hydrogel functionalized silicone reservoir. A PEG-based made reactive NCO-sP(EO-stat-PO) prepolymers was evaluated...
<b><i>Introduction:</i></b> Transimpedance measurements from cochlear implant electrodes have the potential to identify anomalous electrode array placement, such as tip fold-over (TFO) or fold-back, basal kinking, buckling. Analysing transimpedance may thus replace intraoperative post-operative radiological imaging detect any misplacements. A algorithm was previously developed deviations a normal position with aim of intraoperatively detecting TFO. The had been...