A5012668914- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Ear Surgery and Otitis Media
- Head and Neck Anomalies
- Noise Effects and Management
- Vestibular and auditory disorders
- Acoustic Wave Phenomena Research
- Ultrasound Imaging and Elastography
- Speech and Audio Processing
- Hydrogels: synthesis, properties, applications
- 3D Printing in Biomedical Research
- Cerebral Venous Sinus Thrombosis
- Hearing Impairment and Communication
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Phonetics and Phonology Research
- Mesenchymal stem cell research
- Cell Adhesion Molecules Research
- Proteoglycans and glycosaminoglycans research
- Congenital gastrointestinal and neural anomalies
- Underwater Acoustics Research
- Immunotherapy and Immune Responses
- Connective tissue disorders research
- Fetal and Pediatric Neurological Disorders
- Radiology practices and education
MED-EL (Austria)
2015-2024
University of Antwerp
2021-2024
RWTH Aachen University
2007-2017
DWI – Leibniz Institute for Interactive Materials
2014
Hypothesis Using a linear measurement of the cochlea on single radiographic image can reliably estimate complete and two-turn cochlear duct length (CDL) in normal human temporal bone. Background CDL is measured from middle round window to helicotrema. Histologic studies have shown organ Corti (OC) range 25 35 mm. measurements, performed either radiographically or histologically, are quite tedious time-consuming. We propose equations that both using computed tomography (CT) image. Methods...
Capture the human inner-ear malformation types in 3D by segmenting structures from clinical CT (computed tomography) and MR (magnetic resonance) image datasets. Volumetric analysis was done to find variations volume of cochlear part alone complete followed printing segmented models.Using slicer freeware, were anonymized setting a tight grey-scale threshold avoid capturing unwanted volumetric alone. using Form labs desktop printer.We identified 2x normal anatomy (NA) cochlea, 1x enlarged...
Fibrous tissue growth and loss of residual hearing after cochlear implantation can be reduced by application the glucocorticoid dexamethasone-21-phosphate-disodium-salt (DEX). To date, sustained delivery this agent to cochlea using a number pharmaceutical technologies has not been entirely successful. In study we examine novel way continuous local drug into inner ear refillable hydrogel functionalized silicone reservoir. A PEG-based made reactive NCO-sP(EO-stat-PO) prepolymers was evaluated...
Knowledge about cochlear duct length (CDL) may assist electrode choice in implantation (CI). However, no gold standard for clinical applicable estimation of CDL exists. The aim this study is (1) to determine the most reliable radiological imaging method and processing software measuring from routine (2) accurately predict insertion depth CI electrode.Twenty human temporal bones were examined using different sectional techniques (high-resolution computed tomography [HRCT] cone beam [CBCT])....
The optimal placement of a cochlear implant (CI) electrode inside the scala tympani compartment to create an effective electrode–neural interface is base for successful CI treatment. characteristics design include (a) matching every possible variation in inner ear size, shape, and anatomy, (b) electrically covering most neuronal elements, (c) preserving intra-cochlear structures, even non-hearing preservation surgeries. Flexible arrays various lengths are required reach angular insertion...
Objectives: To understand the growth rate of mastoid thickness and skull width associated with age for both normal malformed inner-ear anatomy groups. Also, to determine if there is any mathematical relation between cochlear size as measured by “A” value against age, thickness, width. Methods: Ninety-two computed tomography image datasets human temporal bone were made available that contained (n = 44) 48) anatomies. The subjects ranged from 6 months 79 years. CE marked OTOPLAN preplanning...
Signal processing algorithms are the hidden components in audio processor that converts received acoustic signal into electrical impulses while maintaining as much relevant information possible. should be smart enough to mimic functionality of external, middle and inner-ear provide cochlear implant (CI) user with a hearing experience natural Modern sound strategies based on continuous interleaved sampling (CIS) strategy proposed by B. Wilson 1991, which provided envelope over several...
Conclusions: The present experimental set-up of high spatial resolution cone-beam computed tomography (CBCT) showed advantages demonstrating the critical landmarks cochlea in identifying position intracochlear electrode contacts and has potential for clinical application cochlear implant (CI) surgery. Objective: To evaluate a newly developed CBCT system defining CI array human temporal bone morphological variation. Methods: Standard electrode, flexible tip (Flex28), an with 36 from MED-EL...
Intra-cochlear fibrous tissue formation around the electrode following cochlear implantation affects impedance as well explantation during reimplantation surgeries. Applying corticosteroids in is one way of minimizing intra-cochlear electrode. It were J. Kiefer, C. von Ilberg, and W. Gstöttner who proposed first idea on drug delivery application to MED-EL year 2000. During twenty years translational research efforts at collaboration with several clinics institutions from across world,...
Despite its enormous biological importance, a lack of mechanical stability and fast degradability often hampers more intense application hyaluronic acid (HA) for biomedical applications. We present method to prepare based hydrogels with tailored stability, porosity by cross-linking functional 18 kDa six arm star shaped poly(ethylene oxide-stat-propylene oxide) (sP(EO-stat-PO)) prepoylmers in aqueous solutions. In the case NCO groups at distal ends arms, occurs through reaction OH HA...
Layer-by-layer techniques bear great potential for biomaterials as they allow sequential construction of hierarchical constructs. This especially accounts hydrogels which can be tuned biochemically, morphologically and mechanically different microenvironments find numerous applications encapsulation release drugs cells. Here we present a novel radiation-free preparation method multi-membrane based on polysaccharides using prepolymer cross-linkers. Isocyanate functional prepolymers were used...
ABSTRACT The objective of this study is to determine the variations in size and shape most widely recognized cochlear malformation types using three‐dimensional (3D) visualization. Using 3D slicer freeware, complete inner‐ear structures were segmented from 46 anonymized high‐resolution computed tomography (HRCT) image datasets. Cochlear height, internal auditory canal width measured axial plane. basal turn diameter was oblique coronal Number turns images corresponding duct length (CDL)...
Objectives The aim of this study is to compare the common cavity (CC) with normal anatomy inner ear in order evaluate whether representing both cochlear and vestibular parts revisit CC deformity from a three‐dimensional (3D) perspective. Methods High‐resolution computed tomography image datasets 17 temporal bones initially identified as were evaluated 3D reconstruction multiplanar analysis using free available software for segmentation ear. All images compared Maximum minimum diameter...
The cochlear implant (CI) as a treatment option for single-sided deafness (SSD) started with clinical study looking in to the influence of implantation MED-EL device on incapacitating unilateral tinnitus SSD. began 2003 and was conducted by P. Van de Heyning his team Antwerp, Belgium. first CI SSD without Germany implanted J. Mueller R. Jacob Koblenz 2005. Translational research activities took place since then evaluate not only adults but also children. They assessed hearing performance...
Background Mesenchymal stem cells (MSC) represent a particularly attractive cell type for bone tissue engineering because of their ex vivo expansion potential and multipotent differentiation capacity. MSC are readily differentiated towards mature osteoblasts with well-established protocols. However, frequently involves three-dimensional scaffolds which (i) allow adhesion in spatial environment (ii) meet application-specific criteria, such as stiffness, degradability biocompatibility....
To develop skills sufficient for hearing preservation cochlear implant surgery, surgeons need to perform several electrode insertion trials in ex vivo temporal bones, thereby consuming relatively expensive carriers. The objectives of this study were evaluate the characteristics electrodes a plastic scala tympani model and fabricate radio opaque polymer filament dummy equivalent mechanical properties. In addition, should aid design development new electrodes. Automated force measurement is...
Objectives: The primary aim was to measure the volume of scala tympani (ST) and length straight portion cochlear basal turn from micro-computed tomography (μCT) images. secondary estimate electrode insertion force based on size speed. Both these objectives have a direct clinical relevance in robotic assisted implant (CI) surgery. Methods: ST segmented thirty μCT datasets create three-dimensional (3D) model calculate volume. diameter (A-value), width (B-value), (S-value) were measured oblique...
Abstract The A-value used in cochlear duct length (CDL) estimation does not take malformed cochleae into consideration. objective was to determine the reported literature, assess accuracy of measurement and evaluate a novel distinguishing cochlea. High resolution Computer Tomography images oblique coronal plane/cochlear view 74 human temporal bones were analyzed. C-value evaluated as predictors inner ear malformation type. proximity facial nerve basal turn subjectively. 26 publications...
The Auditory Brainstem Implant (ABI) is based on the classic cochlear implant (CI) but uses a different stimulation electrode. At MED-EL, early development activities ABI started in year 1994, with suggestion coming from J. Helms and Müller Würzburg, Germany collaboration Univ. of Innsbruck Austria. first surgery neuro-fibromatosis (NF2) patient MED-EL device took place 1997. Later, indication was expanded to non-NF2 patients severe inner-ear malformation, for whom regular CI will not be...