A5047161195- Hearing, Cochlea, Tinnitus, Genetics
- Ear Surgery and Otitis Media
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Bacterial Infections and Vaccines
- Speech and Audio Processing
- Sinusitis and nasal conditions
- Pneumonia and Respiratory Infections
- Neuropeptides and Animal Physiology
- Otolaryngology and Infectious Diseases
- Streptococcal Infections and Treatments
- Dental Radiography and Imaging
- Respiratory and Cough-Related Research
- Tracheal and airway disorders
- Ear and Head Tumors
- Bone Tissue Engineering Materials
- Sleep and Wakefulness Research
- Regulation of Appetite and Obesity
- Research in Social Sciences
- Hearing Impairment and Communication
- Nasal Surgery and Airway Studies
- Pediatric health and respiratory diseases
- Acoustic Wave Phenomena Research
- Facial Nerve Paralysis Treatment and Research
- Sleep and related disorders
University of Helsinki
2016-2025
Helsinki University Hospital
2016-2025
Hospital District of Helsinki and Uusimaa
2004-2025
Institute for Molecular Medicine Finland
2023
Kainuun keskussairaala
2011-2021
Helsinki Children's Hospital
2021
Harvard University
2009-2015
Tampere University
2015
Boston Children's Hospital
2015
Tampere University Hospital
2015
Neuropeptides FF (NPFF), AF (NPAF), and SF (NPSF) are homologous amidated peptides that were originally identified on the basis of similarity to molluscan neuropeptide FMRF-amide. They have been hypothesized wide-ranging functions in mammalian central nervous system, including pain modulation, opiate function, cardiovascular regulation, neuroendocrine function. We cloned NPFF gene from human, bovine, rat, mouse, show precursor mRNA encodes for all three biochemically (NPFF, NPAF, NPSF)....
This pilot study shows that transcutaneous vagus nerve stimulation (tVNS), if combined with sound therapy (ST), reduces the severity of tinnitus and tinnitus-associated distress. Our magnetoencephalography (MEG) results show auditory cortical activation can be modulated by application tVNS. Thus, tVNS might offer a new avenue to treat distress.Recent studies suggest improved tailored ST or VNS plus ST. aims were whether has therapeutic effects on patients and, additionally, acoustically...
Purpose: To determine the applicability of cone-beam computed tomography (CBCT) in otological imaging, and to compare its accuracy with routinely used multislice helical CT (MSCT) for imaging middle- inner-ear areas. Material Methods: Thirteen unoperated human cadaver temporal bones were imaged CBCT MSCT. Sixteen landmarks middle adjacent inner ear evaluated compared their conspicuity according a modified Likert scale. Total scores subgroups including specific clinical interest also...
Background The development of modern medicine has resulted in changes the predisposing conditions, clinical picture, treatment and results intracranial abscesses. This study sought to evaluate these a hospital district. Methods A retrospective analysis data all patients treated due abscesses at tertiary referral centre, between 1970-2012. Results total number was 166. incidence 0.33/100 000/year (2000-2012). most common conditions were infection ear-, nose- throat region (22%), odontogenic...
Transcutaneous vagal nerve stimulation (tVNS) might offer a targeted, patient-friendly, and low-cost therapeutic tool for tinnitus patients with sympathovagal imbalance.Conventionally, VNS has been performed to treat severe epilepsy depression an electrode implanted the cervical trunk of vagus nerve. This study investigated acute effects tVNS on autonomic nervous system (ANS) imbalance, which often occurs in tinnitus-triggered stress.This retrospectively analysed records 97 who had undergone...
Transcranial direct current stimulation (tDCS) has shown potential for providing tinnitus relief, although positive effects have usually been observed only during a short time period after treatment. In recent studies the focus turned from one-session experiments towards multi-session treatment investigating long-term outcomes with double-blinded and sham-controlled study designs. Traditionally, tDCS administered in clinical setting by healthcare professional but involving multiple sessions,...
The Finnish Matrix Test is the first sentence test in noise for language. It was developed according to HearCom standards and provides reliable speech intelligibility measurements with highly comparable results other international matrix tests.The aim of study develop an accurate language that across different languages.We chose a test, which comprises base 10 names, verbs, numerals, adjectives nouns. lists were formed from this quasi randomly, providing sentences same syntactical structure....
We designed a study to determine the role of mastoid mucosal biofilm in chronic otitis media (COM).Biofilm formation has been found several airway infections. COM is associated with chronic, recalcitrant infection mucosa, and surgery often required.COM patients were divided into 2 groups: one suppurative (CSOM) cholesteatoma presence. All had involvement preoperative computed tomographic scan. The control group consisted undergoing cochlear implantation, no previous history media. Mastoid...
In Brief Objectives: The ability of a treatment method to interfere with tinnitus-related neural activity patterns, such as cortical gamma rhythms, has been suggested indicate its potential in relieving tinnitus. Therapeutic modulation gamma-band oscillations vagus nerve stimulation recently reported epileptic patients. aim this study was investigate the effects transcutaneous (tVNS) on oscillatory patterns. Design: We calculated power spectral density and synchrony magnetoencephalography...
Objective The aim of this study was to evaluate the results stapes surgery after 20 years follow-up and compare between large fenestra versus small stapedotomy. Study Design Retrospective clinical study. Setting Tertiary referral center (university hospital). Patients One hundred forty-two patients with otosclerosis treated by surgery. Intervention Eighty had a total stapedectomy House-wire prosthesis 62 stapedotomy Teflon-piston prosthesis. Main Outcome Measures Preoperative, postoperative,...
The objectives of this study were to evaluate magnetic resonance imaging (MRI) findings patients with sudden sensorineural hearing loss (SSNHL) and grade the based on their clinical importance.A prospective study.A tertiary referral center (university hospital).MRI 82 consecutive SSNHL fulfilling inclusion criteria.We studied 1.0-T MR images that analyzed by one experienced neuroradiologist.Of six cases (7%) in which clearly was obviously associated observed pathology, four had an acoustic...
<h3>BACKGROUND AND PURPOSE:</h3> MR imaging is often used for detecting intracranial complications of acute mastoiditis, whereas the intratemporal appearance mastoiditis has been overlooked. The aim this study was to assess features caused by in and their clinical relevance. <h3>MATERIALS METHODS:</h3> Medical records findings 31 patients with (21 adults, 10 children) were analyzed retrospectively. degree opacification temporal bone, signal enhancement characteristics, bone destruction,...
To evaluate and compare clinical microbiological findings in adults hospitalized for acute otitis media (AOM) or mastoid infections (acute latent).We retrospectively reviewed the medical records of all (≥17 years old) (between 2003 2012) at a tertiary referral center AOM not responding to outpatient treatment.Of 160 patients study sample, 19% had an infection caused by S. pyogenes, 14% pneumoniae, 11% P. aeruginosa. was most common (38%), whereas 33% mastoiditis (AM), 18% latent (LM), 13% AM...
Purpose: Children develop social-pragmatic understanding with the help of sensory, cognitive, and linguistic functions by interacting other people. This study aimed to explore (a) associations between auditory, demographic, factors in children who use bilateral hearing aids (BiHAs) or cochlear implants (BiCIs) typically (TH) (b) effect group (BiHA, BiCI, TH) on when effects are controlled for. Method: The Pragma test was used assess 119 six-year-old children: 25 BiHAs, 29 BiCIs, 65 TH...
Conscripts have a risk for an acute acoustic trauma (AAT) due to exposure large-caliber weapons or explosions despite the much tighter safety precautions than those rifle-caliber weapons. We aimed investigate population-based frequency of AATs after such noise sources during conscript training in Finnish Defence Forces (FDF), and evaluate their possible causes. collected all registered AAT incidents from FDF over available periods 1997-2003 2008--2010. The likelihood having heavy weapon...
Conclusions: The present experimental set-up of high spatial resolution cone-beam computed tomography (CBCT) showed advantages demonstrating the critical landmarks cochlea in identifying position intracochlear electrode contacts and has potential for clinical application cochlear implant (CI) surgery. Objective: To evaluate a newly developed CBCT system defining CI array human temporal bone morphological variation. Methods: Standard electrode, flexible tip (Flex28), an with 36 from MED-EL...
The most common cause for Eustachian tube dilatory dysfunction is mucosal inflammation. aim of this study was to validate a scale inflammation, based on digital video clips obtained during diagnostic rigid endoscopy.A previously described four-step grading the degree inflammation mucosa lumen used validation study. A tutorial use scale, including static images and 10 second clips, presented 26 clinicians with various levels experience. Each clinician then reviewed 35 short samples tubes from...
To evaluate the predisposing factors for otogenic intracranial abscesses, assess their changes over time, and analyze how they differ from those due to other causes.The medical records of all patients treated between 1970 2012 at a tertiary referral center, were retrospectively analyzed. The analysis included patient demographics, clinical characteristics, causative pathogens, treatments, outcomes, comparisons non-otogenic abscesses.Of 11% (n=18) otogenic. In 1970s, infections common factor...
Implantation of a biomaterial provides an adhesion substratum both to host cell integration and contaminating bacteria. We studied simultaneous competitive Staphylococcus aureus in serial 1:10 dilutions 108 colony forming units (CFU)/mL human osteogenic sarcoma (SaOS-2) or primary osteoblast (hOB) cells, 1x105 cells/mL, the surfaces titanium, polydimethylsiloxane polystyrene. The bacterial adherence proliferation, cytotoxicity production reactive oxygen species (ROS) were using fluorometric...
To assess the susceptibility of salivary stones to bacterial biofilm formation, which may be involved in development gland infection, and investigate a relation between microbiological aspects patient characteristics. This prospective study comprises 54 patients with sialolithiasis attended Helsinki University Hospital during 2014–2016. A total 55 were removed, studied for formation using fluorescence microscopy sonication. The isolated organisms quantified identified matrix-assisted laser...