Frank Louwen

ORCID: 0000-0003-2320-3313
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About
Contact & Profiles
Research Areas
  • Maternal and Perinatal Health Interventions
  • Pregnancy and preeclampsia studies
  • Assisted Reproductive Technology and Twin Pregnancy
  • Pregnancy-related medical research
  • Maternal and fetal healthcare
  • Prenatal Screening and Diagnostics
  • Neonatal Respiratory Health Research
  • Birth, Development, and Health
  • Microtubule and mitosis dynamics
  • Maternal Mental Health During Pregnancy and Postpartum
  • Neonatal and fetal brain pathology
  • Medical and Health Sciences Research
  • Cardiovascular Issues in Pregnancy
  • Fetal and Pediatric Neurological Disorders
  • Pelvic floor disorders treatments
  • Gestational Diabetes Research and Management
  • Congenital Diaphragmatic Hernia Studies
  • Reproductive System and Pregnancy
  • Pregnancy and Medication Impact
  • Ectopic Pregnancy Diagnosis and Management
  • COVID-19 Impact on Reproduction
  • Anesthesia and Pain Management
  • Pelvic and Acetabular Injuries
  • Cancer-related Molecular Pathways
  • Reproductive Health and Contraception

Goethe University Frankfurt
2016-2025

University Hospital Frankfurt
2016-2025

Klinik für Frauenheilkunde
2011-2021

Asklepios Fachklinikum Brandenburg
2019

Bürgerhospital Frankfurt am Main
2019

Krankenhaus Köln-Holweide
2017

Universitätsklinikum Gießen und Marburg
2017

Kliniken der Stadt Köln
2017

Dr. A. Ramachandran's Diabetes Hospitals
2017

Institute for Quality and Efficiency in Health Care
2017

Abstract BACKGROUND Breast carcinoma during pregnancy (BCP) is a difficult clinical situation, as it appears to put the health of mother in conflict with that fetus. METHODS An international expert meeting was conducted form guidelines on how diagnose and treat women BCP. RESULTS The goal for treatment pregnant woman breast same nonpregnant patient: local control disease prevention systemic metastases. However, certain modalities need be modified because potential adverse effects There...

10.1002/cncr.21610 article EN Cancer 2005-12-09

Abstract Objective To compare breech outcomes when mothers delivering vaginally are upright, on their back, or planning cesareans. Methods A retrospective cohort study was undertaken of all women who presented for singleton delivery at a center in Frankfurt, Germany, between January 2004 and June 2011. Results Of 750 with term delivery, 315 (42.0%) planned received cesarean. 269 successful vaginal deliveries neonates, 229 the upright position were compared 40 dorsal position. Upright...

10.1002/ijgo.12033 article EN cc-by-nc International Journal of Gynecology & Obstetrics 2017-01-04

Substandard or disrespectful care during labour should be of serious concern for healthcare professionals, as it can affect one the most important events in a woman's life. refers to use interventions that are not considered best-practice, inadequate execution interventions, situations where best-practice withheld from patients, there is lack adequate informed consent. Disrespectful forms verbal and non-verbal communication patients' dignity, individuality, privacy, intimacy, personal...

10.1016/j.ejogrb.2024.02.048 article EN cc-by-nc-nd European Journal of Obstetrics & Gynecology and Reproductive Biology 2024-02-29

Adipose-derived stem cells are capable of differentiating into multiple cell types and thus considered useful for regenerative medicine. However, this differentiation feature seems to be associated with tumor initiation metastasis raising safety concerns, which requires further investigation. In study, we isolated adipose-derived from subcutaneous as well visceral adipose tissues the same donor systematically compared their features. Although being characteristic mesenchymal cells, tend...

10.18632/oncotarget.5922 article EN Oncotarget 2015-09-30

Abstract Background Patient safety is a key target in public health, health services and medicine. Communication between all parties involved gynecology obstetrics (clinical staff/professionals, expectant mothers/patients their partners, close relatives or friends providing social support) should be improved to ensure patient safety, including the avoidance of preventable adverse events (pAEs). Therefore, interventions an app will developed this project through participatory approach...

10.1186/s12913-019-4579-y article EN cc-by BMC Health Services Research 2019-11-28

Abstract Purpose The aim of this study was to investigate characteristics associated with ectopic pregnancy (EP) that could be utilized for predicting morbidity or mortality. Methods This a retrospective analysis pregnancy-related records from tertiary center over period ten years. Data on age, gravidity, parity, EP risk, amenorrhea duration, abdominal pain presence and location, β-human chorionic gonadotropin (β-HCG) level, ultrasound findings, therapeutic intervention, exact implantation...

10.1186/s12958-021-00761-w article EN cc-by Reproductive Biology and Endocrinology 2021-06-01

BackgroundPatient Blood Management (PBM) is a patient-centred, systematic, evidence-based approach to improve patient outcomes by managing and preserving patient's own blood whilst promoting safety empowerment. The effectiveness of PBM over longer period have not yet been investigated.MethodsWe performed prospectively designed, multicentre follow-up study with non-inferiority design. Data were retrospectively extracted case-based from electronic hospital information systems. All in-hospital...

10.1016/j.bja.2023.05.006 article EN cc-by-nc-nd British Journal of Anaesthesia 2023-06-26

Breast cancer is the most frequently diagnosed and a common cause of cancer-related death in women. It well recognized that obesity associated with an enhanced risk more aggressive breast as reduced patient survival. adipose tissue-derived mesenchymal stromal/stem cells (bASCs) are crucial components tumor microenvironment. A key step initially involved this process might be de-differentiation bASCs into supporting phenotypes.In present work, we isolated from tissues adjacent to (aT bASCs)...

10.1186/s13046-022-02592-y article EN cc-by Journal of Experimental & Clinical Cancer Research 2023-01-30

Leukocyte adhesion deficiency II has been described in only 2 patients; herein we report extensive investigation of another patient. The physical stigmata were detected during prenatal ultrasonographic investigation. Sialyl-Lewis X (sLex) was absent from the surface polymorphonuclear neutrophils, and cell binding to E- P-selectin severely impaired, causing an immunodeficiency. elevation peripheral neutrophil counts occurred within several days after birth. A severe hypofucosylation...

10.1016/s0022-3476(99)70281-7 article EN other-oa The Journal of Pediatrics 1999-06-01

Adipose-derived mesenchymal stem cells (ASCs) are considered to be a useful tool for regenerative medicine, owing their capabilities in differentiation, self-renewal, and immunomodulation. These have become focus the clinical setting due abundance easy isolation. However, ASCs from different depots not well characterized. Here, we analyzed functional similarities differences of subcutaneous visceral ASCs. Subcutaneous an extraordinarily directed mode motility highly dynamic focal adhesion...

10.3390/cells8101288 article EN cc-by Cells 2019-10-21
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