A5016747342- Reproductive System and Pregnancy
- Renal Transplantation Outcomes and Treatments
- Immune Cell Function and Interaction
- Dialysis and Renal Disease Management
- Epilepsy research and treatment
- COVID-19 Clinical Research Studies
- Organ Donation and Transplantation
- SARS-CoV-2 and COVID-19 Research
- Dementia and Cognitive Impairment Research
- Organ Transplantation Techniques and Outcomes
- Polyomavirus and related diseases
- Restless Legs Syndrome Research
- Endometriosis Research and Treatment
- Pregnancy and Medication Impact
- Intensive Care Unit Cognitive Disorders
- Cytomegalovirus and herpesvirus research
- Neurological and metabolic disorders
- Bipolar Disorder and Treatment
- Hepatitis B Virus Studies
- Blood groups and transfusion
- Renal and Vascular Pathologies
- Long-Term Effects of COVID-19
- Psychosomatic Disorders and Their Treatments
- Pain Management and Placebo Effect
- Renal Diseases and Glomerulopathies
Justus-Liebig-Universität Gießen
2017-2024
Giessen School of Theology
2018-2024
Philipps University of Marburg
2009-2021
Universitätsklinikum Gießen und Marburg
2009-2013
Patients with recurrent miscarriage (RM) show up-regulated cytotoxic natural killer (NK) cells that are suspected to play a causal role in abortion. In the present study, we investigated counter-regulating inhibitory mechanisms and compared results RM patients those of healthy controls (HC), end-stage renal disease (ESRD) kidney transplant recipients late post-transplant (TX). NK, NK T cell subsets were analysed peripheral blood 31 RM, 14 female ESRD nine TX as well 21 HC using eight-colour...
Abstract Background Cognitive impairment in hemodialysis patients has been acknowledged over the last years and reported up to 80% of patients. Older age, high prevalence cardiovascular risk factors, such as stroke transient ischemic attack, uremia, multiple metabolic disturbances represent most common factors for cognitive Methods We conducted a prospective cohort study on 408 from 10 centers regional government district Middle Hesse (Germany). Patients underwent neuropsychological test...
Previously, we demonstrated up-regulated activated CD4+ and CD8+ T lymphocytes as well cytotoxic NK cells in the blood of patients with idiopathic recurrent miscarriage. In present study, tried to identify deficiencies counter-regulating immune mechanisms these patients. Cytokines were determined plasma samples 35 healthy controls, 33 miscarriage, 34 end stage renal disease, 10 transplant early 37 late post-transplant using flow-cytometry luminex. addition, cytokines studied supernatants...
Objectives Due to demographic change and high incidence of epilepsy in elderly, the number elderly with epilepsies is increasing. However, only few studies investigated impact on quality life (QoL). We how affects different aspects QoL dependent age patients onset epilepsy. Materials methods In a multicenter, cross-sectional study, three patient groups were recruited from five centers: Group A1: 45 (≥65 years.) late years), group A2: 51 early-onset, long-lasting (≤50 B: 41 young adults...
Abstract Purpose The association between sarcopenia of kidney transplant recipients and outcome after transplantation (KT) has not yet been fully understood is still considered controversial. aim our study was to analyze the impact pre-transplant on graft function, postoperative complication rates, survival patients renal transplantation. Methods In this retrospective single-center study, all who underwent KT (01/2013–12/2017) were included. Demographic data, rejection delayed patient rates...
Delayed graft function (DGF) occurs in a significant proportion of deceased donor kidney transplant recipients and was associated with injury inferior clinical outcome. The aim the present multi-center study to identify immunological non-immunological predictors DGF determine its influence on outcome presence absence human leukocyte antigen (HLA) antibodies. 1,724 patients who received during 2008–2017 whom pre-transplant serum sample available were studied. Graft survival first 3...
There is evidence that NK-cell reactivity might affect graft outcome in transplant recipients and pregnancy women.NK-cell subsets were determined whole blood using eight-colour-fluorescence flow cytometry patients before after renal transplantation, with recurrent miscarriage (RM) healthy controls (HC).Patients late post-transplant (late-Tx) functioning transplants showed abnormally low CD56dimCD16+ NK-cells containing both perforin granzyme (vs HC p = 0.021) whereas RM exhibited high...
Abstract Background Association of cognitive impairment with chronic kidney disease has been reported over the last decade. Individuals show better performance after transplantation than individuals on dialysis but are more likely to be affected by age-matched comparison groups. Better knowledge prevalence as well course and profile is important for design future studies assessing clinical impact developing management strategies. The goal our study examine extent before derive a distinct...
Gaps still exist regarding knowledge on regulatory cells in transplant recipients. We studied the phenotypic patterns of CD4+, CD8+CD28- Tregs, and CD19+IL-10+ Bregs blood healthy controls (HC), end-stage kidney disease patients (ESKD), early late stable renal recipients (Tx), with steroid-treated acute cellular rejection 1 week-3 months after successful treatment. also investigated relationship between immunosuppressive drugs aforementioned recipients.We recruited 32 HC, 83 ESKD, 51 Tx, 95...
Cognitive impairment in chronic kidney disease, especially end stage renal is a public health problem. Nevertheless, the cause of disease still remains unclear. A prevalence cognitive patients with up to 87% has been found.The study at hand deals research on - potential effect timing performance when testing hemodialysis during dialysis cycle. We tested neuropsychological test battery (RBANS, Repeatable Battery for Assessment Neuropsychological Status) two occasions while were as well...
It is important to learn more about the prevalence, severity and characteristics (i.e., which cognitive abilities are especially affected) of impairment in kidney transplant patients. Furthermore, impact living vs. deceased donor renal transplantation on outcome this patient group needs further studies.
Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Collaborative Transplant Study. Introduction: We reported previously that early adverse events in deceased donor kidney transplantation, such as delayed graft function (DGF) and rejection episodes, are associated with pre-transplant presence of HLA antibodies patients show significantly impaired survival rates. In the meantime, introduction sensitive antibody detection techniques is expected to have diminished involvement overlooked DGF. On other hand, DGF risk might increased due growing...
BACKGROUND Recently, in patients with long-term functioning allografts, we showed that high NKG2D+ NK cell numbers the peripheral blood were associated a higher glomerular filtration rate, whereas NKG2A+ cells lower rate. Both determinants react ligands (MIC A/B, HLA-E) expressed on stressed cells, such as virus-infected tumor or activated during graft rejection. In present study, attempted to characterize these 2 subsets further. MATERIAL AND METHODS Using flow cytometry, analyzed...
Compared with the general population, patients receiving maintenance dialysis are at increased risk for morbidity and mortality associated coronavirus disease 2019 (COVID-19). Currently, data on severe acute respiratory syndrome type 2 (SARS-CoV-2)-specific immunity post-vaccination in scarce given that effectiveness of vaccines has not been explicitly tested this population due to their common exclusion from SARS-CoV-2 vaccination trials. We herein present specific cellular (interferon-γ...
The shortage of organs for transplantation remains a global problem. retransplantation previously transplanted kidney might be possibility to expand the pool donors. We provide our experience with successful reuse kidneys in Eurotransplant region.A query database was performed between January 1, 1995 and December 31, 2015, find donors who themselves had received graft.Nine out total 68,554 allocated been transplanted. Four these were once again. mean interval first transplant 1689±1682 days...