A5008299244- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Organ Donation and Transplantation
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Renal Diseases and Glomerulopathies
- Polyomavirus and related diseases
- Renal and Vascular Pathologies
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Neurological Complications and Syndromes
- Liver Disease and Transplantation
- Complement system in diseases
- Organ and Tissue Transplantation Research
- Pregnancy and Medication Impact
- Metabolism and Genetic Disorders
- Pharmacological Effects and Toxicity Studies
- HIV/AIDS drug development and treatment
- Adenosine and Purinergic Signaling
- Herpesvirus Infections and Treatments
- RNA regulation and disease
- Advanced biosensing and bioanalysis techniques
- Reproductive System and Pregnancy
- Blood groups and transfusion
Heidelberg University
2015-2024
University Hospital Heidelberg
2010-2024
German Center for Infection Research
2024
University Hospital Regensburg
2018
University Medical Centre Mannheim
2016
Immungenetics (Germany)
2016
Development Fund
2014
Weatherford College
2009
Heidelberg University
2008
Institute of Immunology
2002
We used the Collaborative Transplant Study database to analyze incidence, risk, and impact of malignant lymphomas in approximately 200,000 organ transplant recipients. Over a 10-year period, risk renal recipients was 11.8-fold higher than that matched nontransplanted population (p<0.0001). The majority were diagnosed after first post-transplant year. Heart-lung transplants showed highest relative (RR 239.5) among different types transplants. In kidney recipients, immunosuppression with...
Good HLA-A, HLA-B, and HLA-DR matches do not guarantee rejection-free renal transplantation. Some kidney transplants fail despite such matches, suggesting that other antigens might be targets for rejection. Major-histocompatibility-complex (MHC) class I-related chain A (MICA) are polymorphic can elicit antibody production. We sought to determine whether an immune response MICA play a role in the failure of allografts.Pretransplantation serum samples from 1910 recipients deceased donors were...
Based on an analysis of United Network for Organ Sharing data, it was reported that the influence human leukocyte antigen (HLA) matching in renal transplantation has diminished recent years, prompting suggestion donor kidney allocation algorithms should be revised.We compared impact HLA graft survival during decades 1985-1994 and 1995-2004 using data Collaborative Transplant Study. Results last 5 years (2000-2004) were analyzed separately addition. Multivariate Cox regression used to account...
Background Kidney graft survival has never been systematically compared between Europe and the United States. Methods Applying period analysis to first deceased-donor (DD) living-donor kidney grafts from Network for Organ Sharing/Organ Procurement Transplantation States Collaborative Transplant Study Europe, we overall age-specific 1-, 5-, 10-year Europeans white, African, Hispanic Americans 2005 2008 period. A Cox regression model was used adjust differences in patient characteristics....
It was reported recently that treatment of kidney transplant recipients with angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II type 1 receptor blockers (ARB) is associated strikingly improved long-term graft and patient survival. This finding has important implications for future posttransplantation therapy recommendations. In an analysis 17,209 1744 heart recipients, association ACEI/ARB outcome could not be confirmed. concluded recommendations a widespread use in are unwarranted.
Background. It is widely assumed that the graft-enhancing properties of antilymphocyte induction agents and their lymphoma-inducing potential are intimately related. Methods. The Collaborative Transplant Study (CTS) database was used to evaluate graft survival non-Hodgkin lymphoma at 3 years according type in 112,122 patients receiving a deceased-donor renal transplant during 1985 2004. Results. relative risk 3-year loss versus no 1.07 (95% confidence interval [CI], 1.01–1.13; P=0.016) with...
Reports from experienced centers suggest that recipients of an ABO-incompatible living-donor kidney transplant after reduction ABO antibodies experience no penalty in graft and patient survival versus ABO-compatible transplants, but confirmation these results can be widely replicated is lacking.Living-donor transplants donors antibody registered with the Collaborative Transplant Study during 2005 to 2012 were analyzed compared (i) a matched group (ii) all performed at least five grafts study...
It is unclear whether kidney transplant recipients with preformed donor-specific human leukocyte antigen (HLA) antibodies (DSA) detectable only in the highly sensitive Luminex single-antigen (LSA) assay are at an increased risk of graft failure.We studied 3148 patients who received a deceased donor between 1996 and 2008 were enrolled prospective serum project Collaborative Transplant Study. There 118 loss during first 3 years after transplantation on whom recipient DNA was available for...
In survival analysis, competing events preclude the occurrence of event interest. The censoring is common in medical studies but leads to biased cumulative incidence estimators. Competing risks methods, such as non-parametric Aalen-Johansen method or semi-parametric Fine and Gray model, alleviate this bias should be preferred above Kaplan-Meier Cox respectively. As an illustrative example, a large European cohort, we report on differences estimates graft failure after kidney transplantation,...
A large prospective study of steroid withdrawal was performed within the framework Collaborative Transplant Study to analyze long-term graft and patient outcome in renal heart transplant recipients. Steroids were withdrawn no earlier than 6 months posttransplantation. comparison 7-year outcomes recipients (94% receiving cyclosporine; 97% Caucasian) showed a benefit versus continuation retrospectively matched controls, for survival (81.9% +/- 1.8% vs. 75.3% 1.2%, p = 0.0001), (88.8% 1.5% 84.3...
ABSTRACT. The identification of high immunologic responders is desirable for the selection appropriate immunosuppressive regimens. With collaboration 29 transplant centers in 15 countries, we investigated whether pretransplant serum content soluble CD30 (sCD30), a marker activation state Th2-type cytokine producing T cells, useful predictor kidney graft outcome. Pretransplant sera 3899 cadaver recipients were tested sCD30 concentration using commercially available enzyme-linked immunosorbent...
Background. The aim of this analysis was to investigate the relationship acute rejection episodes (ARE) at different times posttransplantation with reversibility graft dysfunction and long-term failure using data from Collaborative Transplant Study database. Methods. A total 28,867 patients receiving their between 1995 2005 deceased donors were included in analysis. time renal transplantation first treated ARE divided into intervals up 3 years. Long-term survival half-life rates calculated...
BACKGROUND.: Despite the importance of non-Hodgkin lymphoma (NHL) as a posttransplant complication, relationship between NHL and recipient seropositivity for Epstein-Barr virus (EBV) or cytomegalovirus (CMV) is incompletely understood. METHODS.: Kidney, heart, liver transplant recipients reported to Collaborative Transplant Study with known pretransplant EBV CMV serostatus were analyzed in terms clinically manifest NHL. Cox multivariate regression analysis was performed account wide range...
Background. There have been striking changes during the last 10 years concerning choice of calcineurin inhibitor and antimetabolite agent prescribed after kidney transplantation. Methods. A retrospective analysis 51,303 patients undergoing deceased-donor transplantation 1998 to 2007 was performed using multivariate regression analysis. All received cyclosporine (CsA) or tacrolimus (Tac) with azathioprine (AZA) mycophenolic acid (MPA) on an intention-to-treat basis corticosteroids plus/minus...
The impact and relationship of donor age, human leukocyte antigen (HLA) matching, posttransplant non-Hodgkin lymphoma in pediatric kidney recipients are not completely understood.We analyzed Collaborative Transplant Study data from 9209 transplant to examine the effects age HLA match on graft survival between occurrence lymphoma.Survival rates using donors aged 11 17, 18 34, or 35 49 years were similar. Cox regression analysis showed that two HLA-DR mismatches associated with lower...
The association of donor-specific HLA antibodies (DSA) with kidney graft failure has been addressed previously; however, the majority studies were based on small numbers patients failure.We investigated 83 failed transplants for a possible de novo development and persistence or loss pre-existing DSA failure. Single Antigen Bead assay-detected non-DSA compared between matched controls functioning grafts.The incidence weak at mean fluorescence intensity 500 higher was in than nonrejector group...
HLA mismatches may correlate with risk of death a functioning graft (DWFG) because requirement for higher immunosuppression doses and more antirejection therapy. Deceased-donor kidney transplants (n = 177 584) performed 1990-2009 reported to the Collaborative Transplant Study were analyzed. The incidence DWFG was found be 4.8% during year 1 posttransplant 7.7% years 2-5 (Kaplan-Meier estimates). Most frequent causes infection, cardiovascular disease malignancy (32.2%, 30.9% 3.6% in 1; 16.4%,...