A5103219610- Radiopharmaceutical Chemistry and Applications
- Probiotics and Fermented Foods
- Monoclonal and Polyclonal Antibodies Research
- Growth Hormone and Insulin-like Growth Factors
- Gut microbiota and health
- Cancer therapeutics and mechanisms
- Metabolism, Diabetes, and Cancer
- Bioactive Compounds and Antitumor Agents
- PI3K/AKT/mTOR signaling in cancer
- Photosynthetic Processes and Mechanisms
- Synthetic Organic Chemistry Methods
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Asymmetric Hydrogenation and Catalysis
- Neuroblastoma Research and Treatments
- Protein purification and stability
- Medical Imaging Techniques and Applications
- Microbial Metabolites in Food Biotechnology
- Medical Imaging and Pathology Studies
- Sociology and Education Studies
- Algal biology and biofuel production
- Traditional and Medicinal Uses of Annonaceae
- Synthesis and Biological Evaluation
- Microbial Natural Products and Biosynthesis
Arvinas (United States)
2017-2024
Novartis (Switzerland)
2015-2023
SymbioPharm (Germany)
2007-2023
Queensland University of Technology
2022
Bristol-Myers Squibb (United States)
2003-2021
Novartis Institutes for BioMedical Research
2015
Paul Scherrer Institute
2000-2013
Institut für Mikroökologie
2011
University of Maryland, Baltimore
2011
University of Salford
2003
Spot on: Bacterial transglutaminase enables the site-specific modification of Gln side chains tumor-targeting antibodies with various probes containing lysine or surrogates. The method yields completely homogeneous immunoconjugates a defined stoichiometry. In comparative in vivo studies xenografted mice pharmacological profiles for enzymatically conjugated were better than those chemically modified analogues. Detailed facts importance to specialist readers are published as ”Supporting...
The insulin-like growth factor I receptor (IGF-IR) is a transmembrane tyrosine kinase that essential to and development also thought provide survival signal for the maintenance of transformed phenotype. There has been increasing interest in further understanding role IGF-I signaling cancer developing antagonists therapeutic application. We describe herein novel animal model involves transgenic expression fusion constitutively activated by homodimerization. Transgenic mice expressed showed...
Lactic acid bacteria (LAB) strains OB14 and OB15 were isolated from traditional Tunisian fermented dairy products, Testouri cheese Rigouta, respectively. They identified as Enterococcus faecalis by the MALDI TOF-MS (matrix assisted laser desorption-ionization time of flight mass spectrometry) biotyper system molecular assays (species-specific PCR). These new isolates evaluated for probiotic properties, compared to E. Symbioflor 1 clone DSM 16431, reference. The found be tolerant harsh...
Probiotic microorganisms, especially lactic acid bacteria, are effective in the treatment of infectious diarrhoeal diseases and experimental colitis. Although mechanisms by which these organisms exert their anti-inflammatory effects largely unknown, immunomodulating suggested. The objective this study was to examine effect a 5-week oral administration Lactobacillus rhamnosus subspecies GG ( Lb . GG) on cellular immune response intestinal microorganisms ten healthy volunteers. Peripheral...
Compound 3 (BMS-536924), a novel small-molecule inhibitor of the insulin-like growth factor receptor kinase with equal potency against insulin is described. The in vitro and vivo biological activity this interesting compound also reported.
ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTDiscovery of a 2,4-Disubstituted Pyrrolo[1,2-f][1,2,4]triazine Inhibitor (BMS-754807) Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical DevelopmentMark D. Wittman*‡, Joan M. Carboni⊥, Zheng Yang#, Francis Y. Lee⊥, Melissa Antman∞, Ricardo Attar⊥, Praveen Balimane#, Chiehying Chang×, Cliff Chen⊥, Lorell Discenza⊥, David Frennesson‡, Marco Gottardis⊥, Ann Greer⊥, Warren Hurlburt⊥, Walter Johnson‡, R. Langley§, Aixin Li⊥, Jianqing Li∥,...
Abstract Purpose: We examined the tumor-targeting and therapeutic effects of 67Cu-labeled single amino acid mutant forms anti-L1 monoclonal antibody chCE7 in nude mice with orthotopically implanted SKOV3ip human ovarian carcinoma cells. Experimental Design: For radioimmunotherapy, antibodies a mutation histidine 310 to alanine (chCE7H310A) asparagine 297 glutamine (chCE7agl) were generated achieve more rapid blood clearance. Biodistributions...
While the discovery of immune checkpoint inhibitors has led to robust, durable responses in a range cancers, many patients do not respond currently available therapeutics. Therefore, an urgent need exists identify alternative mechanisms augment immune-mediated clearance tumors. Hematopoetic progenitor kinase 1 (HPK1) is serine-threonine that acts as negative regulator T-cell receptor (TCR) signaling, dampen response. Herein we describe structure-based isofuranones HPK1. Optimization...
Abstract Purpose: The L1 cell adhesion protein is overexpressed in tumors, such as neuroblastomas, renal carcinomas, ovarian and endometrial represents a target for tumor diagnosis therapy with anti-L1-CAM antibody chCE7. Divalent fragments of this internalizing labeled 67/64Cu 177Lu were evaluated to establish chCE7 fragment radioimmunotherapy positron emission tomography imaging, which combines high-yield production improved clearance biodistribution properties. Experimental Design:...
Reduction of Acute Relapses in Patients with Chronic Recurrent Hypertrophic Sinusitis during Treatment a Bacterial Immunostimulant (Enterococcus faecalis Bacteriae Human Origin – Medical Probiotic) A double-blind, placebo-controlled multicenter study 157 patients chronic recurrent sinusitis investigated the occurrence acute relapses treatment bacterial +immunostimulant (3 × 30 drops/day), comprised cells and autolysate human <i>Enterococcus faecalis</i> bacteria (Symbioflor® 1, n = 78)...
ABSTRACT Here, we report the complete and annotated genome sequence of probiotic Enterococcus faecalis Symbioflor 1 clone DSM 16431, included in a commercial product used for more than 50 years without any reports infection. This will provide new insights into biology this nonpathogenic microorganism.
To date, virulent bacteria remain the basis of most mediated cancer therapies. For clinical application attenuation is required. However, this might result in a drastically lowered therapeutic capacity. Herein we argue that E. coli probiotic Symbioflor-2, with history safe may constitute viable tumor candidate. We demonstrate Symbioflor-2 displays highly specific targeting ability as determined murine CT26 and RenCa models. The excellent specificity was ascribed to reduced levels adverse...
Abstract The L1‐cell adhesion molecule (L1‐CAM) is highly expressed in various cancer types including ovarian carcinoma but absent from most normal tissue. A chimeric monoclonal antibody, chCE7, specifically binds to human L1‐CAM and exhibits anti‐proliferative effects on L1‐CAM‐expressing tumor cells. goal of this study was evaluate the efficacy a novel 177 Lu‐chCE7 radioimmunotherapeutic agent compare it treatment protocol with unlabeled, growth‐inhibiting chCE7 mouse xenograft model...
Probiotic bacteria have a wide range of applications in veterinary and human therapeutics. Inactivated probiotics are complex samples quality control (QC) should measure as many molecular features possible. Capillary electrophoresis coupled to mass spectrometry (CE/MS) has been used multidimensional high throughput method for the identification validation biomarkers disease biological such biofluids. In this study we evaluate suitability CE/MS consistency different lots probiotic formulation...
A former subgenus of the genus Lactobacillus, "Streptobacterium," comprises a wide range species, including so-called "atypical streptobacteria," which includes Lactobacillus sake-Lactobacillus curvatus group. Various identification systems and differentiation criteria for L. sake have been described previously are well established. The phenotypic diversity within these two species was reason comparing variations with DNA homology data. Previously biotypes (Katagiri, Kitahara, Fukami)...
Site-specific enzymatic reactions with microbial transglutaminase (mTGase) lead to a homogenous species of immunoconjugates defined ligand/antibody ratio. In the present study, we have investigated influence different numbers 1,4,7,10-tetraazacyclododecane-N-N′-N′′-N′′′-tetraacetic acid (DOTA) chelats coupled decalysine backbone on in vivo behavior chimeric monoclonal anti-L1CAM antibody chCE7agl. The conjugation (DOTA)1-decalysine, (DOTA)3-decalysine or (DOTA)5-decalysine heavy chain (via...
273 Background: The Androgen Receptor (AR) remains the principal driver of castration-resistant prostate cancer during transition from a localized to metastatic disease. Most patients initially respond inhibitors AR pathway, but response is often short-lived. majority progressing on enzalutamide or abiraterone exhibit genetic alterations in locus, either form amplifications point mutations gene. Given these mechanisms resistance, our goal eliminate protein using PROteolysis TArgeting Chimera...
We previously reported that 1 (BMS-536924), a benzimidazole inhibitor of the insulin-like growth factor-1 receptor, had demonstrated in vivo antitumor activity. This lead compound was found to have potent CYP3A4 inhibition, induction mediated by PXR transactivation, poor aqueous solubility, and high plasma protein binding. Herein we disclose evolution this chemotype address these issues. effort led 10 (BMS-695735), which exhibits improved ADME properties, low risk for drug-drug interactions,...