A5104094587- Cardiac Valve Diseases and Treatments
- Cardiac and Coronary Surgery Techniques
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Structural Anomalies and Repair
- Coronary Interventions and Diagnostics
- Mechanical Circulatory Support Devices
- Protease and Inhibitor Mechanisms
- Cardiac Arrest and Resuscitation
- Antimicrobial Resistance in Staphylococcus
- Congenital Heart Disease Studies
- Cardiac Ischemia and Reperfusion
- Streptococcal Infections and Treatments
- Thermal Regulation in Medicine
- Blood Coagulation and Thrombosis Mechanisms
- Pericarditis and Cardiac Tamponade
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cardiovascular Function and Risk Factors
- Thermoregulation and physiological responses
- Hemodynamic Monitoring and Therapy
- Anesthesia and Neurotoxicity Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Kawasaki Disease and Coronary Complications
- Surgical site infection prevention
Rabin Medical Center
2010-2024
Tel Aviv University
2001-2024
Emek Medical Center
2022
New York University
2003-2006
Tel Aviv Sourasky Medical Center
2001-2005
Carmel Medical Center
1997-2000
KU Leuven
1999
Rappaport Family Institute for Research in the Medical Sciences
1999
Background— Patients with severe atheromatous aortic disease (AAD) who undergo coronary artery bypass (CABG) have an increased risk of death and stroke. We hypothesized that in these high patients, off-pump (OPCAB) technique is associated lower morbidity mortality. Methods Results— Between June 1993 January 2002, 5737 patients undergoing CABG had routine intra-operative TEE 913 (15.9%) found to AAD the arch or ascending aorta. Of these, 211 underwent OPCAB were matched on-pump by age,...
Serine proteases are a key component of the inflammatory response as they discharged from activated leukocytes and mast cells or generated through coagulation cascade. Their enzymatic activity plays major role in body's defense mechanisms but it has also an impact on vascular homeostasis tissue remodeling. Here we focus biological serine context cardiovascular disease their mechanism(s) action determining specific phenotypes. Protease-activated receptors (PARs) mediate protease effects;...
Minimally invasive, nonsternotomy approaches for valve procedures may reduce the risks associated with cardiac surgery after prior sternotomy and improve outcomes. We analyzed our institutional experience to test this hypothesis.Between 1995 2002, 498 patients previous operations via underwent isolated surgery: 337 median (aortic = 160; mitral 177) 161 mini-thoracotomy 61; 100). Data were collected prospectively using New York State Cardiac Surgery Report Form.Preoperative incidences of...
Abstract Increased Troponin I levels and pro-inflammatory cytokines have been reported in most patients undergoing cardiac surgery, ascribed to the type extent of reperfusion injury, method myocardial protection. We investigated their on-pump (CCAB) or off-pump (OPCAB) coronary artery bypass surgery whether these correlated with injury. One hundred twenty were prospectively randomized undergo OPCAB (n = 60) CCAB 60). Hemodynamic respiratory data, as well serum CK-MB mass fraction, I,...
Introduction— Although minimally invasive aortic valve surgery (MIAVR) is performed in many centers, few studies have compared its results to a standard sternotomy (SS) approach. We assessed the hypothesis that, when with SS elderly population, MIAVR has similar morbidity and mortality allows faster hospital recovery. Methods Results— From January 1995 through February 2002, 515 patients over age 65 underwent isolated replacement. Using data gathered prospectively, 189 were matched by age,...
Matrix metalloproteinases (MMPs) play key roles in vascular remodeling. We characterized the role of inflammatory mediators and extracellular signal-regulated kinases (ERKs) control arterialized vein graft expression MMP-9, MMP-2, membrane-type 1-MMP (MT1-MMP) tissue inhibitor metalloproteinases-2 (TIMP-2). For this purpose we used a canine model jugular to carotid artery interposition analyzed grafts at various postoperative times (30 min 28 days) using contralateral as control. To study...
We assessed the cardioprotective effects of perioperative maintenance normothermia by determining profile troponin I, a highly cardiac-specific protein important in risk stratification patients with acute ischemic events. Candidates for their primary coronary artery bypass grafting (CABG) were randomized into new thermoregulation system group, Allon( (AT; n = 30), and routine thermal care (RTC; 30) group. Anesthetic operative techniques similar both groups. Intraoperative warming was applied...
We assessed the cardioprotective effects of perioperative maintenance normothermia by determining profile troponin I, a highly cardiac-specific protein important in risk stratification patients with acute ischemic events. Candidates for their primary coronary artery bypass grafting (CABG) were randomized into new thermoregulation system group, Allon™ (AT;n = 30), and routine thermal care (RTC;n 30) group. Anesthetic operative techniques similar both groups. Intraoperative warming was applied...
Vancomycin concentrations in serum, tissues, and sternum, administered as prophylaxis to patients during coronary artery bypass surgery, were measured. (15 mg/kg) was 15 1 hour before skin incision. Blood, tissue, sternum samples collected before, during, after bypass. The concentration serum at the end of infusion 55.1 +/- 22.8 microg/mL, mean elimination half-life 9 4 hours, areas under concentration-time curve (AUC) from 0 12 hours infinity 90.6 25.1 289.7 86.5 microg/h per mL,...
Abstract Basic fibroblast growth factor (FGF‐2) and matrix metalloproteinases (MMPs) play key roles in vascular remodeling. Because FGF‐2 controls a number of proteolytic activities various cell types, we tested its effect on endothelial expression MMP‐3 (stromelysin‐1), broad‐spectrum proteinase implicated coronary atherosclerosis. Endothelial cells (EC) from −/− mice are highly responsive to exogenous were therefore used for this study. The results showed that treatment microvascular EC...