A5070890820- Cardiac Valve Diseases and Treatments
- Cardiac and Coronary Surgery Techniques
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Cardiac, Anesthesia and Surgical Outcomes
- Protease and Inhibitor Mechanisms
- Cardiac Arrest and Resuscitation
- Cardiac Ischemia and Reperfusion
- Aortic aneurysm repair treatments
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Angiogenesis and VEGF in Cancer
- Congenital Heart Disease Studies
- Transplantation: Methods and Outcomes
- Cardiac Imaging and Diagnostics
- Peptidase Inhibition and Analysis
- Fibroblast Growth Factor Research
- Blood Coagulation and Thrombosis Mechanisms
- Coronary Interventions and Diagnostics
- Coronary Artery Anomalies
- Reconstructive Surgery and Microvascular Techniques
- Cardiac tumors and thrombi
- Vascular Procedures and Complications
NYU Langone Health
2016-2025
New York University
2009-2022
Hinge Health
2021
Landscape Research Group
2016
Columbia University Irving Medical Center
1993-2013
VA NY Harbor Healthcare System
2010
University Medical Center
1997-2010
Columbia University
2009
Manitoba Health
2009
Abbott (Sweden)
2009
FGF-2 and VEGF are potent angiogenesis inducers in vivo vitro. Here we show that induces expression vascular endothelial cells through autocrine paracrine mechanisms. Addition of recombinant to cultured or upregulation endogenous results increased expression. Neutralizing monoclonal antibody inhibits FGF-2–induced cell proliferation. Endogenous 18-kD production upregulates extracellular interaction with membrane receptors; high-Mr (22–24-kD) acts via intracellular mechanism(s). During...
Previous studies have provided conflicting evidence as to whether an increased risk of mediastinitis is associated with use the internal mammary artery a coronary bypass graft. In this study effects grafts on wound complications were analyzed in prospective, nonrandomized fashion. At New York University Medical Center from January 1985 through May 1988, 2356 patients underwent isolated revascularization. Among these 1394 received one or more (group I) and 962 had vein only II). Group I mean...
Background. This study analyzes a single institutional experience with minimally invasive mitral valve operations of 6 years, reviewing short-term morbidity and mortality long-term echocardiographic follow-up data.Methods. Seven hundred fourteen consecutive patients had procedures between November 1995 2001; concomitant included 91 multiple valves 18 coronary artery bypass grafts. Of these 714 patients, 561 isolated (375 repairs, 186 replacements). Mean age was 58.3 years (range, 14 to 96...
PURPOSE: To evaluate gadolinium-enhanced three-dimensional magnetic resonance (MR) angiography for thoracic aortic disease and to compare this technique with conventional MR imaging. MATERIALS AND METHODS: One hundred eight consecutive patients underwent 122 examinations, including imaging followed by enhanced angiography. A gradient-echo sequence was used at 1.5 T (116 examinations) 1.0 (6 during infusion of 0.2 mmol/kg gadopentetate dimeglumine. Two independent readers (A B), varied...
The risk for stroke after transcatheter aortic valve replacement (TAVR) is an important concern. Identification of predictors likely to be a critical factor aiding patient selection and management as TAVR use becomes widespread.Patients enrolled in the CoreValve US Extreme Risk High Pivotal Trials or Continued Access Study treated with self-expanding bioprosthesis were included this analysis. 1-year rate was 8.4%. Analysis hazard identified early phase (0-10 days; 4.1% strokes) late (11-365...
VEGF and TGF-beta1 are potent angiogenesis inducers with opposing effects on endothelial cells. induces apoptosis; protects cells from apoptosis. We found that promotes cell expression of FGF-2, which up-regulates synthesis. Inhibition signaling through receptor 2 (flk-1) abrogates TGF-beta1-induced apoptosis p38(MAPK) activation. blocks apoptosis, showing VEGF/flk-1-mediated activation is required for induction In the absence TGF-beta1, activates survival. However, in context results Thus,...
We investigated chest wall blood flow in a canine model to determine if the technique used harvest mammary artery has differential effect on residual flow. Eight dogs underwent bilateral internal mobilization; one was harvested as pedicle and other skeletonized vessel. Residual distribution of each measured with radioactive microspheres. Chest significantly decreased from preharvest levels after mobilization regardless used. Tissue flows 46.9%, 22.1%, 41.2% baseline values for manubrium (p <...
Membrane-type 1 matrix metalloproteinase (MT1-MMP), a transmembrane proteinase with short cytoplasmic domain and an extracellular catalytic domain, controls variety of physiological pathological processes through the proteolytic degradation or proteins. MT1-MMP forms complex on cell membrane its protein inhibitor, tissue inhibitor metalloproteinases-2 (TIMP-2). Here we show that, in addition to proteolysis, TIMP-2 control proliferation migration non-proteolytic mechanism. binding induces...
Heparin bonding of the cardiopulmonary bypass (CPB) pump circuit decreases complement activation and fibrinolysis. It is not known whether inflammatory cytokines produced during CPB can also be modulated by more biocompatible heparin-coated circuit.This initial study evaluated impact heparin-bonded circuits on production interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-a), IL-6, IL-8 in adults undergoing complex cardiac operations with prolonged CPB. Twenty patients had blood samples...