A5102945324- Immunotherapy and Immune Responses
- Cardiac Valve Diseases and Treatments
- Trypanosoma species research and implications
- Insect symbiosis and bacterial influences
- Occupational Health and Safety in Workplaces
- Stress and Burnout Research
- Monoclonal and Polyclonal Antibodies Research
- Forest ecology and management
- Mechanical Circulatory Support Devices
- Esophageal and GI Pathology
- Cancer Immunotherapy and Biomarkers
- Helminth infection and control
- Parasitic Diseases Research and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Arrest and Resuscitation
- COVID-19 and healthcare impacts
- Tracheal and airway disorders
- Infective Endocarditis Diagnosis and Management
- Research on Leishmaniasis Studies
- Tuberculosis Research and Epidemiology
- Cancer Research and Treatments
- Immune Cell Function and Interaction
- Dysphagia Assessment and Management
- Aortic Disease and Treatment Approaches
- Respiratory viral infections research
Central University of Venezuela
2010-2023
Universidad Nacional Autónoma de México
2023
Hospital Universitario De Cabueñes
2021
The University of Texas MD Anderson Cancer Center
2021
Clínica CES
2017
Universidad CES
2017
Alkermes (United States)
2015-2017
Mount Sinai Medical Center
2011-2016
Centro Científico Tecnológico - Tucumán
2014
Universidad Nacional de Cuyo
2014
The risk for stroke after transcatheter aortic valve replacement (TAVR) is an important concern. Identification of predictors likely to be a critical factor aiding patient selection and management as TAVR use becomes widespread.Patients enrolled in the CoreValve US Extreme Risk High Pivotal Trials or Continued Access Study treated with self-expanding bioprosthesis were included this analysis. 1-year rate was 8.4%. Analysis hazard identified early phase (0-10 days; 4.1% strokes) late (11-365...
Chagas' disease is caused by the protozoan Trypanosoma cruzi and autochthonous to Americas. Its distribution depends on triatomine bugs that are responsible for transmission of disease. In 2005, we reported presence Panstrongylus geniculatus as a risk in Caracas neighboring areas. Three massive oral outbreaks occurred following years. Here report results 7-year study species found Metropolitan District (MDC), Venezuela. Triatomine collected inhabitants during 7 years were analyzed parasite...
Abstract Objectives To evaluate feasibility and technical outcomes in patients with aortic stenosis (AS) who have undergone high‐risk procedures continuous flow left ventricular (LV) assist, the Impella 2.5 system (Abiomed, Danvers, MA). Background In preparation for transcatheter valve implantation, an increasing number of severe AS dysfunction are currently considered percutaneous coronary interventions (PCI) balloon valvuloplasty (BAV). Hemodynamic support may be required some patients....
Oral outbreaks of Chagas disease are increasingly reported in Latin America. The transitory presence Trypanosoma cruzi parasites within contaminated foods, and the rapid consumption those precludes precise identification outbreak origin. We report source attribution for 2 peri-urban oral Venezuela via high resolution microsatellite typing.
<i>Context:</i> Octogenarians are the fastest growing segment of population and little is known about results cardiopulmonary resuscitation (CPR) after in-hospital cardiac arrest in this population. <i>Objective:</i> We sought to investigate clinical benefit cost-effectiveness CPR octogenarians. <i>Main Outcome Measure:</i> Years life saved. <i>Design:</i> Effectiveness data were obtained from a review 91,372 hospital discharges January 1st,...
Chagas disease is a significant public health risk in rural and semi-rural areas of Venezuela. Triatomine infection by the aetiological agent Trypanosoma cruzi also observed Metropolitan District Caracas (MDC), where foodborne T . outbreaks occasionally occur but active vector-to-human transmission (infection during triatomine bloodmeal) considered absent. Citizen science-based domiciliary collection carried out between 2007 2013 MDC has advanced understanding urban prevalence patterns...
Aortic stenosis (AS) has been considered an exclusion criterion for the use of Impella 2.5 catheter. We describe a case in which catheter was successfully implanted and used hemodynamic support during balloon aortic valvuloplasty high-risk patient severe AS with calculated valve area 0.59 cm2 .
Abstract Percutaneous intervention of chronic limb ischemia is often limited by vascular access especially in patients with previous surgical interventions. This warrants development alternative endovascular techniques, particularly for whom traditional ipsilateral antegrade or contralateral retrograde has failed not possible. We describe a novel approach to the posterior tibial artery using transradial techniques including closure devices two inaccessible access. © 2011 Wiley Periodicals, Inc.
En las zonas áridas de Argentina, los bosques Prosopis flexuosa son suma importancia porque protegen el suelo en áreas con riesgo elevado desertificación, y ofrecen diversos recursos a pobladores locales (e.g., leña, forraje productos alimenticios derivados sus frutos). La actividad antrópica ha tenido un fuerte impacto sobre estos bosques, especial desde la segunda mitad del siglo XIX. Por lo tanto, conocer su distribución potencial compararla actual permitirá definir prioritarias para...
Abstract Chronic total occlusions remain a technical challenge for interventional cardiologists. This group of lesions carries decreased rate success and continues to be an important reason surgical revascularization. Recently, retrograde percutaneous coronary intervention via epicardial septal perforators was introduced as alternative approach when previous antegrade attempt has failed. We describe unique case where used the initial recanalization technique in absence right ostium.© 2010...
En este trabajo se presenta el estado de desarrollo un sistema orientado a entrenadores y atletas alto rendimiento para la mejora técnica del lanzamiento disco. El está basado en análisis información proporcionada por unidades medida inerciales (IMU) una cámara vídeo. Inicialmente, las IMU ubican cinco puntos cuerpo lanzador, así como interior La utilidad es proporcionar aceleraciones ángulos orientación que permitan derivar parámetros biomecánicos atleta, identificar fases temporales...
Abstract ALKS 4230 is a novel immunotherapeutic agent being tested in an ongoing phase 1 study to evaluate safety and tolerability the treatment of patients with refractory solid tumors. selective agonist intermediate-affinity interleukin 2 (IL-2) receptor that when administered mice results significant increase numbers memory CD8+ T cells NK no expansion CD4+ regulatory (Tregs). The selectivity achieved by due fact molecule fusion circularly permuted IL-2 extracellular portion α, resulting...
Abstract RDB 1450 is an engineered fusion protein which selectively activates the intermediate-affinity IL-2 receptor present on NK cells and memory CD8 T cells. In rodents, has a half-life of 6-8 hours, compared to minutes for recombinant human (rhIL-2). Repeat daily dosing (QD) in mice results marked expansion CD8+CD44high cells, with minimal CD4+ regulatory (Tregs). Higher QD doses elicit more pronounced effector cell modest pulmonary edema. TID delivery same total dose enhances...
En las zonas áridas de Argentina, los bosques Prosopis flexuosa son suma importancia porque protegen el suelo en áreas con riesgo elevado desertificación, y ofrecen diversos recursos a pobladores locales (e.g., leña, forraje productos alimenticios derivados sus frutos). La actividad antrópica ha tenido un fuerte impacto sobre estos bosques, especial desde la segunda mitad del siglo XIX. Por lo tanto, conocer su distribución potencial compararla actual permitirá definir prioritarias para...
Abstract RDB 1450 is an engineered fusion protein of circularly permuted IL-2 and IL-2Rα that selective for the intermediate-affinity receptor. The receptor comprised beta chain (CD122) common gamma (CD132) expressed on lymphocytes with effector function, whereas high-affinity receptor, which additionally includes alpha (CD25), primarily immunosuppressive CD4+CD25+ regulatory T cells (Tregs). Ex vivo proliferation subsets human in response to or rhIL-2 were evaluated. supports activation...