A5102922753- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Aortic Disease and Treatment Approaches
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Radiation Dose and Imaging
- Mechanical Circulatory Support Devices
- Cardiac and Coronary Surgery Techniques
- Cerebrovascular and Carotid Artery Diseases
- Acute Myocardial Infarction Research
- Advanced X-ray and CT Imaging
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Health and Disease Prevention
- Advanced MRI Techniques and Applications
- Acute Ischemic Stroke Management
- Cardiac Arrhythmias and Treatments
- Coronary Interventions and Diagnostics
- Advanced Radiotherapy Techniques
- Radioactivity and Radon Measurements
- Congenital Heart Disease Studies
- Anatomy and Medical Technology
- Rheumatoid Arthritis Research and Therapies
- Heparin-Induced Thrombocytopenia and Thrombosis
West Suffolk Hospital
2011-2024
West Suffolk NHS Foundation Trust
2013-2024
Piedmont Atlanta Hospital
2015-2024
Valve (United States)
2017-2023
Mayo Clinic in Arizona
2022
Baylor Jack and Jane Hamilton Heart and Vascular Hospital
2020
Cardiovascular Research Foundation
2020
Icahn School of Medicine at Mount Sinai
2020
Presbyterian Hospital
2018
Aurora St. Luke's Medical Center
2018
Among patients with heart failure who have mitral regurgitation due to left ventricular dysfunction, the prognosis is poor. Transcatheter mitral-valve repair may improve their clinical outcomes.
For patients with symptomatic, severe tricuspid regurgitation (TR), early results of transcatheter valve (TV) intervention studies have shown significant improvements in functional status and quality life associated right-heart reverse remodelling. Longer-term follow-up is needed to confirm sustained these outcomes.
<h3>Importance</h3> Transcatheter aortic valve replacement (TAVR) is established for selected patients with severe stenosis. However, limitations such as suboptimal deployment, conduction disturbances, and paravalvular leak occur. <h3>Objective</h3> To evaluate if a mechanically expanded (MEV) noninferior to an approved self-expanding (SEV) in high-risk stenosis undergoing TAVR. <h3>Design, Setting, Participants</h3> The REPRISE III trial was conducted 912 high or extreme risk severe,...
The risk for stroke after transcatheter aortic valve replacement (TAVR) is an important concern. Identification of predictors likely to be a critical factor aiding patient selection and management as TAVR use becomes widespread.Patients enrolled in the CoreValve US Extreme Risk High Pivotal Trials or Continued Access Study treated with self-expanding bioprosthesis were included this analysis. 1-year rate was 8.4%. Analysis hazard identified early phase (0-10 days; 4.1% strokes) late (11-365...
Background As transcatheter aortic valve replacement expands to younger and/or lower risk patients, the long‐term consequences of permanent pacemaker implantation are a concern. Pacemaker dependency and impact have not been methodically assessed in trials. We report incidence predictors after with Lotus valve. Methods Results A total 912 patients high/extreme surgical symptomatic stenosis were randomized 2:1 (Lotus:CoreValve) REPRISE III (The Repositionable Percutaneous Replacement Stenotic...
Abstract Aims The REFLECT I trial investigated the safety and effectiveness of TriGuard™ HDH (TG) cerebral embolic deflection device in patients undergoing transcatheter aortic valve replacement (TAVR). Methods results This prospective, multicentre, single-blind, 2:1 randomized (TG vs. no TG) study aimed to enrol up 375 patients, including 90 roll-in patients. primary combined endpoint (VARC-2 defined early safety) at 30 days was compared with a performance goal. efficacy hierarchical...
A 23-year-old man presented to the acute assessment unit with acute-onset haematuria within 24 hours of receiving his second dose Pfizer-BioNTech COVID-19 vaccine. He had been diagnosed IgA vasculitis 8 months previously. is an autoimmune condition characterised by palpable purpura affecting lower limbs, abdominal pain, arthralgia and renal disease. was exacerbation discharged oral prednisolone. Reactivation or first presentation a rare but increasingly recognised complication vaccination....
The alpha(2-)macroglobulin receptor (alpha(2)MR) has been reported to mediate the internalization of urokinase plasminogen activator (uPAR) via ligand binding both receptors. To target malignant uPAR-expressing cells and determine whether uPAR can internalize without alpha(2)MR, we engineered two recombinant toxins, ATF-PE38 ATF-PE38KDEL. Each consists amino-terminal fragment (ATF) human a truncated form Pseudomonas exotoxin (PE) devoid domain Ia, which binds alpha(2)MR. ATF-PE38KDEL were...
Background Gait speed is a reliable measure of physical function and frailty in patients with aortic stenosis undergoing transcatheter valve replacement (TAVR). Slow gait pre‐TAVR predicts worse clinical outcomes post‐TAVR. The consequences improved versus worsened post‐TAVR are unknown. Methods Results REPRISE III (Repositionable Percutaneous Replacement Stenotic Aortic Valve Through Implantation Lotus System–Randomized Clinical Evaluation) trial randomized high/extreme risk to receive...
Disulfide-stabilized Fvs (dsFvs) are recombinant proteins composed of a heavy-chain variable domain (VH) an antibody connected via disulfide bond to the light-chain (VL). In single-chain (scFvs), peptide connector links VH and VL. The dsFv form anti-Tac monoclonal which reacts with alpha subunit IL2 receptor was recently reported be more stable aggregate less during renaturation than anti-Tac(scFv). addition, it could produced in better yield owing aggregation. However, yields still too low...