A5048929879- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Cardiac Arrest and Resuscitation
- Transplantation: Methods and Outcomes
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic aneurysm repair treatments
- Tissue Engineering and Regenerative Medicine
- Coronary Interventions and Diagnostics
- Cardiac Ischemia and Reperfusion
- Congenital Heart Disease Studies
- Organ Transplantation Techniques and Outcomes
- Cardiac and Coronary Surgery Techniques
- Mesenchymal stem cell research
- History of Medical Practice
- Cardiac tumors and thrombi
- Medical History and Innovations
- Cardiac Imaging and Diagnostics
- Electrospun Nanofibers in Biomedical Applications
- Cardiac pacing and defibrillation studies
- Surgical Simulation and Training
- Pulmonary Hypertension Research and Treatments
- Renal Transplantation Outcomes and Treatments
UMass Memorial Medical Center
2017-2023
UMass Memorial Health Care
2017-2023
University of Massachusetts Chan Medical School
2019-2022
Leo Pharma (Australia)
2021-2022
First Affiliated Hospital of Guangzhou Medical University
2018
Guangzhou Medical University
2018
New York University
2010-2017
NYU Langone Health
2011-2017
University of Chieti-Pescara
2016
Umm al-Qura University
2015
A relatively simple, invasive method for quantitatively assessing the status of coronary microcirculation independent epicardial artery is lacking.By using a pressure wire and modified software, it possible to calculate mean transit time room-temperature saline injected down artery. The inverse hyperemic has been shown correlate with absolute flow. We hypothesize that distal divided by provides an index microcirculatory resistance (IMR) will true (TMR), defined as left anterior descending...
The effect of epicardial artery stenosis on myocardial microvascular resistance remains controversial. Recruitable collateral flow, which may affect resistance, was not incorporated into previous measurements. In an open-chest pig model, distal coronary pressure measured with a wire, and the apparent minimal calculated during peak hyperemia as divided by either flow probe around (R(micro app)) or novel thermodilution technique (apparent index microcirculatory [IMR(app)]). These resistances...
Insulin-like growth factor-1 (IGF-1) promotes myocyte proliferation and can reverse cardiac abnormalities when it is administered in the early fetal stage. Supplementation of a mouse embryonic stem cell (ESC) suspension with IGF-1 might enhance cellular engraftment host organ-specific differentiation after injection area acute myocardial injury. In study reported here, we sought to restorative effect ESCs injured heart by adding injected population. Green fluorescent protein (GFP)-labeled...
Thermodilution coronary flow reserve (CFRthermo) is a new technique for invasively measuring (CFR) with pressure wire and based on the ability of transducer to also measure temperature changes. Whether CFRthermo correlates well enough absolute flow-derived CFR (CFRflow) replace Doppler wire-derived (CFRDoppler) remains unclear.In an open-chest pig model, was measured in left anterior descending (LAD) artery compared CFRDoppler CFRflow, external probe placed around LAD. In 9 pigs,...
Background— Ischemia–reperfusion injury is an important risk factor for graft coronary artery disease (GCAD). We hypothesized that overexpression of SOD1 in donor hearts would suppress ischemia—reperfusion and thereby reduce GCAD. Methods Results— In one series, C57BL/6 (H-2 b ) transgenic mice overexpressing human or wild-type were heterotopically transplanted into recipients procured after 4 hours reperfusion (n=6 each). Superoxide, TNF-α, MCP-1/CCL2 production significantly reduced the...
Activating transcription factor-3 (ATF-3) is one member of a large family leucine zipper factors which bind to promoters responsive cAMP and phorbol ester at the related (CRE) response elements. We report here that ATF-3 coexpressed with neuropeptide precursor proenkephalin in human neuroblastoma SK-N-MC cells. Cotransfection experiments indicate activation gene expression by dependent upon both catalytic subunit cAMP-dependent protein kinase CRE-2 element. The element essential for second...
In the intestine, lung, and urinary tract, neutrophil (polymorphonuclear leukocyte, PMN) transepithelial migration is dependent on leukocyte beta2 integrin CD11b/CD18. While regions of CD11b involved in recognition several soluble ligands are known, those that mediate PMN-epithelial interactions have not been investigated. this study, mAbs reactive with four extracellular CD11b, NH2-terminal region, I (inserted) domain, cation-binding region proximal to transmembrane domain (C domain), were...
Various types of three-dimensional matrices have been used as basic scaffolds in myocardial tissue engineering. Many those are limited by insufficient mechanical function, availability, or biocompatibility. We present a clinically established collagen scaffold for the development bioartificial tissue. Neonatal rat cardiomyocytes were seeded into Tissue Fleece (Baxter Deutschland, Heidelberg, Germany). Histological and ultrastructural examinations performed DAPI DiOC(18) staining electron...
Refractory postoperative bleeding complicates a significant number of cardiac surgical procedures and results in both morbidity mortality. Conventional strategies to effect hemostasis include reexploration administration blood products. In some cases, remains intractable despite these methods, alternatives are needed. Herein, we report our experience with the use factor eight inhibitor bypassing activity (FEIBA), coagulation concentrate, for refractory bleeding.A retrospective review FEIBA...
A global outbreak of invasive Mycobacterium chimaera infections after cardiac surgery has recently been linked to bioaerosols from contaminated heater-cooler units. The majority cases have occurred valvular or aortic graft and nearly half resulted in death. To date, patients with left ventricular assist devices (LVADs) not characterized the literature. We report two device-associated M. infection continuous-flow LVADs describe challenges related diagnosis management this population.
Recent Society of Thoracic Surgeons and Cardiovascular Anesthesiologists (STS/SCA) guidelines highlight the safety blood conservation strategies in routine cardiac surgery. We evaluated feasibility impact such a program complex aortic surgery.Between March 2010 October 2011, 63 consecutive replacement procedures were performed: root (n = 17; 27%), ascending aorta 15; 23.8%), arch 19; 30.2%), descending 8; 12.7%), thoracoabdominal 4; 6.3%). Aortic dissections present 32 patients. A...