We and others have previously demonstrated that the endothelium is a primary target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), L-arginine has been shown to improve endothelial dysfunction. However, effects never evaluated in disease 2019 (COVID-19).This parallel-group, double-blind, randomized, placebo-controlled trial conducted on patients hospitalized for COVID-19. Patients received 1.66 g twice day or placebo, administered orally. The efficacy endpoint was reduction...

Most recent studies have stressed a high risk of thromboembolism in patients with SARS-CoV-2 infection, particularly those severe COVID-19 pneumonia. Counterbalance between angiotensin-converting-enzyme (ACE) and ACE2 activities disease may be crucially involved the thrombo-inflammatory process. Currently, no study has investigated ACE I/D polymorphism involvement complicated by pulmonary embolism, hence aim present pilot study. This is retrospective, single-center observational case-control...

We have recently demonstrated in a double-blind randomized trial the beneficial effects of L-Arginine patients hospitalized for COVID-19. hypothesize that one mechanisms underlying favorable is its action on inflammatory cytokines. To verify our hypothesis, we measured longitudinal plasma levels pro-inflammatory and anti-inflammatory cytokines implied pathophysiology COVID-19 to receive oral or placebo. The study was successfully completed by 169 patients. Patients arm had reduced...

Background: Pneumomediastinum, subcutaneous emphysema and pneumothorax are not rarely observed during the COVID-19 pandemic. Such complications can worsen gas exchange overall prognosis in critical patients. The aim of this study is to investigate what predisposing factors related pneumomediastinum SARS-CoV2-Acute Respiratory Distress Syndrome (ARDS), symptoms may predict a severe potentially fatal complication therapeutical approach provide better outcome. Methods: In single center cohort...

Bronchiectasis is the consequence of chronic bronchial inflammation, inappropriate mucus clearance, bacterial colonization, and recurrent or infection. High flow therapy (HFT) a type non-invasive respiratory therapy, usually delivered through nasal cannula interface (HFNC). It delivers heated humidified air with stable fraction inspired oxygen wide range possible rates. Determine effectiveness HFNC as add-on in adult primary secondary bronchiectasis frequent acute exacerbations (AEs) and/or...

Background: Home treatment of patients affected by COVID-19 is still a matter daily debate. During the clinical evolution disease, there are high risks lung failure, which requires oxygen therapy. Here, we report our experience with at-home using high-flow nasal cannula in non-hospitalised confirmed COVID-19. Patients and methods: In this study, 18 moderate-to-severe respiratory failure secondary to were monitored at home for temperature SpO2 measurements. Other parameters such as saturation...

Background: Previous studies have demonstrated persistent dyspnoea and impairment of respiratory function in the follow-up patients who recovered from COVID-19 pneumonia. However, no evaluated clinical functional consequences pneumonia complicated by pulmonary embolism. Objective: The aim our study was to assess exercise capacity 3 months after recovery pneumonia, either or not Methods: This a retrospective, single-centre, observational involving 68 adult with positive/negative history...

SARS-CoV-2 is a betacoronavirus that belongs to the family Coronaviridae and order Nidovirales (1). During December 2019, series of pneumonia cases caused by outbreak was identified in Wuhan, Hubei, China, rapidly spread across world. The spectrum disease (COVID 19) varies from asymptomatic or paucisymptomatic forms clinical conditions characterized respiratory failure necessitate mechanical ventilation support an intensive care unit (ICU), multiorgan systemic manifestations, and, terms...

Background and objective: Insertion/deletion polymorphisms of angiotensin-converting enzyme (ACE) have been previously described in association with adult respiratory distress syndrome (ARDS) correlated to outcome. The ACE deletion/deletion(D/D)genotype represents a marker thrombosis subjects apparently without predisposing factors and/or traditional thrombophilic alterations increases the risk venous thromboembolism whom thrombogenic condition occurs. Thrombosis seems play role very early...

Introduction. Alpha-1 antitrypsin deficiency (AATD) is a genetic condition associated with several respiratory diseases in patients severe protein deficiency. AATD often late diagnosed or underdiagnosed. Diagnosis frequently occurs chronic obstructive pulmonary disease and emphysema characterized by frequent exacerbations over ten years’ duration. The purpose of this study was to evaluate the incidence alpha-1 after thorough screening city Naples southern Italy. Materials methods. Two...

Introduction Severe COVID-19 is a life-threatening condition characterized by complications such as interstitial pneumonia, hypoxic respiratory failure, and acute distress syndrome (ARDS). Non-pharmacological intervention with mechanical ventilation plays key role in treating COVID-19-related ARDS but influenced high risk of failure more severe patients. Dexmedetomidine new generation highly selective α2-adrenergic receptor (α2-AR) agonist that provides sedative effects preservation...

It is important to assess the effectiveness of an antiseizure medication in treating different epilepsy aetiologies optimise individualised therapeutic approaches. Data from PERaMpanel pooled analysIs effecTiveness and tolerability (PERMIT) Extension study were used safety/tolerability perampanel (PER) when treat individuals with a range clinical practice. A post hoc analysis was conducted PERMIT data known aetiology. Retention assessed after 3, 6 12 months. Effectiveness months at last...

Healthcare associated infections (HAI) are a major concern. Infections and sepsis prevalent causes of prolonged hospitalization, healthcare resources consumption, mortality. Infection prevention control (IPC) measures need to be encouraged with the purpose become standard protocol. Hand hygiene represents most important measure prevent spread infections. Poor hand is often due to: belief that use gloves replaces hygiene, lack good example from colleagues superiors, sinks difficult access or...

We report four cases of niacin-induced hepatotoxicity. All patients were using sustained-release niacin preparations. When they stopped taking niacin, symptoms and laboratory abnormalities resolved. Two the had focal fatty infiltration liver on imaging studies, a presentation hepatotoxicity not previously described. One patient coagulopathy even though aminotransferase levels only mildly elevated. recommend that preparations have periodic monitoring enzymes preparation be discontinued if any develop.

While available in only a few countries, home therapy is possible strategy for the treatment of alpha-1 antitrypsin deficiency. We want to describe our experience management human using care intravenous augmentation during this emergency period caused by SARS-CoV2 infection. assessed safety and quality life patients enrolled program.

Non-invasive ventilation (NIV) is associated with improvement of both morbility and mortality in patients affected by neuromuscular diseases chronic respiratory failure. Several studies have also shown that long-term NIV positively impacts the patient's quality life perception disease status. Its effectiveness likely related to adherence NIV. factors, patient- not patient-related, may compromise NIV, such as physical, behavioral, familiar, social issues. Few data are currently available on...

The insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) gene, previously described in association with adult respiratory distress syndrome, may play a key role lung injury patients SARS-COV2.In this paper we describe 26 severe failure related to COVID-19 pneumonia that underwent genetic screening for ACE polymorphisms.

Abstract Only a percentage of COVID-19 patients develop thrombotic complications. We hypothesized that genetic profiles may explain part the inter-individual differences. Our goal was to evaluate genotypic distribution targeted DNA polymorphisms in complicated (PE+) or not (PE−) by pulmonary embolism. designed retrospective observational study enrolling N = 94 consecutive suffering severe with embolism (PE+, 47) (PE−, during hospitalization. A panel 13 prothrombotic (FV R506Q and H1299R, FII...