A5020945874- Sinusitis and nasal conditions
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Olfactory and Sensory Function Studies
- Nasal Surgery and Airway Studies
- Biochemical Analysis and Sensing Techniques
- Head and Neck Surgical Oncology
- Otitis Media and Relapsing Polychondritis
- Advanced Chemical Sensor Technologies
- Congenital Ear and Nasal Anomalies
- Obstructive Sleep Apnea Research
- Oral and Maxillofacial Pathology
- Cleft Lip and Palate Research
- Tracheal and airway disorders
- Immunodeficiency and Autoimmune Disorders
- Oropharyngeal Anatomy and Pathologies
- Respiratory and Cough-Related Research
- Voice and Speech Disorders
- Soft tissue tumor case studies
- Mast cells and histamine
- Pediatric health and respiratory diseases
- Neurofibromatosis and Schwannoma Cases
- Vasculitis and related conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Infectious Diseases and Mycology
Sapienza University of Rome
2016-2025
Policlinico Umberto I
2015-2023
Federico II University Hospital
2022
The Sense Innovation and Research Center
2016
Casa Sollievo della Sofferenza
1997
Chronic rhinosinusitis with nasal polyps (CRSwNP) is associated significant morbidity and reduced health-related quality of life. Findings from clinical trials have demonstrated the effectiveness dupilumab in CRSwNP, although real-world evidence still limited.This Phase IV real-life, observational, multicenter study assessed safety patients severe uncontrolled CRSwNP (n = 648) over first year treatment. We collected data at baseline after 1, 3, 6, 9, 12 months follow-up. focused on score...
Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory disease multifactorial etiopathogenesis. This study investigated the recurrence rate and risk factors predicting in patients subjected to Functional Endoscopic Sinus Surgery (FESS) for CRSwNP. Methods: Patients affected by CRSwNP who underwent FESS between January 2015 March 2020 were enrolled. The influence of assessed. Results: A total 154 included, 100 males 54 females, aged 14–82 years (mean age 51.96 ±...
Nasal obstruction is a frequent condition in patients with obstructive sleep apnoea (OSA). leads to mouth breathing, which thought destabilise the upper airway aggravate condition. Three conditions could be considered as cause of nasal breathing obstruction: anatomical nose (septum deviation, hypertrophy inferior turbinates), chronic rhinosinusitis (CRS) and inflammation caused by allergic rhinitis or non-allergic cellular rhinitis. In this prospective study, we present an evaluation all...
Introduction The impairment of the sense smell is often related to chronic rhinosinusitis (CRS) with or without nasal polyps (CRSwNP, CRSsNP). CRSwNP a frequent condition that drastically worsens quality life those affected; it has higher prevalence than CRSsNP. patients experience severe loss earlier presentation and are more likely recurrence their symptoms, requiring revision surgery. Methods present study performed multicentric data collection, enrolling 811 CRS divided according...
Chronic rhinosinusitis with nasal polyps (CRSwNP) in the most severe forms is associated a poor quality of life. Dupilumab has been suggested as an add-on treatment option for CRSwNP. Severe CRSwNP patients treated dupilumab different rhinological units were followed up at 1, 3, 6 and 12 months from first administration considered this study. At baseline (T0) each follow-up, underwent endoscopy completed sinonasal outcome test (SNOT)-22, visual analogue scale (VAS) smell/nasal obstruction,...
Background. Dupilumab represents the first approved biological for severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP). Objective. Aim of this paper is to provide a multicentric real-life study about treatment dupilumab CRSwNP special focus on blood parameters and IgE, IgG, IgA. Method. A retrospective data collection was jointly conducted at Otolaryngology departments San Camillo Forlanini Hospital University Rome “La Sapienza” from December 2020 January 2023. Results....
Background: The introduction of biological drugs in the management chronic rhinosinusitis with nasal polyps (CRSwNP) is allowing new and increasingly promising therapeutic options. This manuscript aims to provide a multicenter trial real-life setting on Mepolizumab treatment for severe uncontrolled CRSwNP or without comorbid asthma. Methods: A retrospective data analysis was jointly conducted at Otolaryngology-Head Neck Surgery departments La Sapienza University San Camillo Forlanini...
Background/Objectives: Chronic rhinosinusitis with nasal polyps (CRSwNP) represents a debilitating disease significant morbidity and decreased quality of life (QoL). The introduction biologics in its management has allowed new therapeutic options, Dupilumab the first approved biologic. This study aims to evaluate possible relationship between clinical response biological therapy mental health patients severe CRSwNP. Methods: is multicenter conducted at Otolaryngology departments three major...
The purpose of this study was to assess olfactory-gustatory function impairment in patients with eating disorders.Nineteen a diagnosis bulimia nervosa, 18 anorexia nervosa and control sample 19 healthy subjects were recruited from the day hospital service Complex Operative Unit for Alimentary Conduct Disorders Policlinico Umberto I Rome. Evaluation olfactory gustatory functions performed on through 'Sniffin' Sticks' method order threshold, capacity discriminating identifying stimuli, overall...
The sense of smell has a high impact on the quality life. aim present study was to investigate olfactory dysfunction in patients with obstructive sleep apnoea syndrome (OSAS) and correlate severity disease dysfunction. relationships between nasal obstruction, mucociliary cleareance tests were also evaluated. Sixty diagnosis OSAS en- rolled underwent function evaluation. In all performance tested Sniffin' Sticks method. Muco- ciliary transport times anterior rhinomanometry performed identify...
: Rhinitis could be considered a risk factor for obstructive sleep apnea (OSA). Studies were conducted to evaluate the relation between OSA and Allergic rhinitis (AR). Non-allergic with eosinophilia syndrome (NARES) is condition symptomatology apparently similar AR. The aim of this study was different presence in patients suffering from NARES
Among the first clinical symptoms of SARS-CoV-2 infection is olfactory−gustatory deficit; this continues for weeks and, in some cases, can be persistent. We prospectively evaluated 162 patients affected by COVID-19 using a visual analogue scale (VAS) nasal and symptoms. Patients were checked after 7, 14, 21, 28, 90, 180 days. A total 118 (72.8%) reported an olfactory VAS < 7 at baseline (group B), 44 (27.2%) anosmia (VAS ≥ 7) A) underwent Brief Smell Identification Test (B-SIT) Burghart...
The aim of this study was to assess pre- and postoperative taste ability in patients undergoing middle ear surgery for otosclerosis or chronic otitis media. Olfactory function also evaluated rule out deficits due concomitant nasal pathology.All underwent ear, nose, throat examination, otomicroscopy, endoscopy, anterior rhinomanometry, testing, olfactory testing. Patients were at 1 5 days preoperatively (T0), (T1), 6 (T6), 12 (T12) months postoperatively.Both groups experienced worsening the...
Loss of smell decreases the quality life and contributes to failure in recognizing hazardous substances. Given relevance olfaction daily life, it is important recognize an undiagnosed olfactory dysfunction prevent these possible complications. Up now, prevalence disorders Italy unknown due a lack epidemiological studies. Hence, primary aim this study was evaluate sample Italian adults.Six hundred thirty-three participants (347 woman 286 men; mean age 44.9 years, SD 17.3, range 18-86) were...
Chronic rhinosinusitis with nasal polyps (CRSwNP) and Severe Eosinophilic Asthma (SEA) are both frequently sustained by eosinophilic inflammation probably the manifestation of a unique disease upper lower respiratory tract. We retrospectively observed 11 patients severe CRSwNP concomitant SEA under add-on therapy benralizumab evaluating symptoms using Sino Nasal Outcome Test-22 (SNOT-22), Visual Analogue Scale (VAS), Control Test (ACT) polyp size endoscopic radiological score Polyp Score...
Objectives: Investigate the presence of Eustachian Tube Dysfunction (ETD) in Obstructive sleep apnea (OSA) patients. Correlate ET function and severity syndrome. nasal resistance mucociliary clearance with onset ETD these patients.Materials methods: Forty patients affected by OSA were enrolled our clinical prospective study. Thirty also investigated as a control group. All analyzed subjects underwent ENT examination, anterior rhinomanometry test for transport time. To evaluate tube score-7...