A5034384991- Sinusitis and nasal conditions
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Head and Neck Cancer Studies
- Nasal Surgery and Airway Studies
- Vestibular and auditory disorders
- Head and Neck Surgical Oncology
- Reconstructive Surgery and Microvascular Techniques
- Respiratory and Cough-Related Research
- Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Voice and Speech Disorders
- Hearing Loss and Rehabilitation
- Infectious Diseases and Mycology
- Cancer, Hypoxia, and Metabolism
- Oral and Maxillofacial Pathology
- Oral and gingival health research
- Neurofibromatosis and Schwannoma Cases
- Gastroesophageal reflux and treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Oral health in cancer treatment
- Olfactory and Sensory Function Studies
- Dysphagia Assessment and Management
- Metabolomics and Mass Spectrometry Studies
- Hearing, Cochlea, Tinnitus, Genetics
Agostino Gemelli University Polyclinic
2020-2024
Università Cattolica del Sacro Cuore
2018-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2023
Corvid Technologies (United States)
2023
Hôpital Saint-Vincent-de-Paul
2006
Chronic rhinosinusitis with nasal polyps (CRSwNP) is associated significant morbidity and reduced health-related quality of life. Findings from clinical trials have demonstrated the effectiveness dupilumab in CRSwNP, although real-world evidence still limited.This Phase IV real-life, observational, multicenter study assessed safety patients severe uncontrolled CRSwNP (n = 648) over first year treatment. We collected data at baseline after 1, 3, 6, 9, 12 months follow-up. focused on score...
The aim of this study was to evaluate the efficacy dupilumab in treatment severe uncontrolled Chronic Rhinosinusitis with Nasal Polyps (CRSwNP), or without asthma as add-on therapy intra-nasal corticosteroids a real-life setting over first year treatment. Our data demonstrated that subcutaneous 300 mg administered at home via pre-filled auto-injector every two weeks, based on indications set by Italian Medicines Agency, rapidly effective reducing size polyps, decreasing symptoms disease,...
Nutritional status is a critical factor throughout COVID-19 disease course. Malnutrition associated with poor outcomes in hospitalized patients.
Chronic rhinosinusitis with nasal polyps (CRSwNP) may have a heterogeneous response to medical/surgical treatments based on endotypes. Data correlating biomarkers and severity of the disease are lacking. We aimed determine if IL-5 calprotectin be useful in defining identifying uncontrolled patients.
Background: Local and systemic corticosteroids have long been the workhorse in management of chronic rhinosinusitis with nasal polyps (CRSwNP), although there is no universally accepted modality prescription. We carried out a survey Italy to capture current trends use topical patients CRSwNP. Methods: A was set up on Survey Monkey®. Each author distributed link an ad hoc manner total 437 participants filled survey. Results: Mometasone furoate (79.3%) most frequently prescribed, administered...
Eosinophilic otitis media (EOM) is a difficult-to-treat characterized by eosinophilic accumulation in the middle ear mucosa and effusion. It resistant to conventional treatments strongly associated with asthma chronic rhinosinusitis nasal polyps (CRSwNP). The aim of our study evaluate effectiveness biologics drugs control EOM. This retrospective no-profit real-life observational study, involving patients affected refractory EOM treatment different for concomitant severe or uncontrolled...
The complex pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP) generates a spectrum phenotypes wide variety inflammatory states. We enrolled 44 very-likely-to-be type 2 CRSwNP patients in order to evaluate the load inflammation and analyze human interleukins secretion. Clinical data were collected severity disease. High levels IL-5, IL-4, IL-6, IL-33 detected all patients. By analyzing cytokine profiles local eosinophil count, we identified two coherent clusters: first was...
Serum amino acid (AA) profiles represent a valuable tool in the metabolic assessment of cancer patients; still, information on AA pattern head and neck (HNC) patients is insufficient. The aim study was to assess whether serum levels were associated with stage neoplastic disease prognosis primary HNC patients.Two hundred two included study. Thirty-one AAs derivatives measured through an ultraperformance liquid chromatography-mass spectrometry (UPLC-MS). association between concentrations...
We conducted a national survey to understand how rhinology practice has changed with the advent of biologics and this affected patients uncontrolled, severe chronic rhinosinusitis nasal polyps (CRSwNP). aimed analyse results infer practical recommendations for clinical practice.A group ear, nose, throat specialists (ENTs) experienced in management CRSwNP developed 74-question survey. ENTs from centres authorised prescribe context health system were invited answer it between 01/05/2022...
in the era of new biological agents it is important to identify patients who may benefit from conventional therapies such as endoscopic sinus surgery (ESS) plus long-term local corticosteroids those with patterns inflammation that are more difficult control post-operatively and other therapies.determine if preoperative assessment type grade clinical factors can predict disease ESS chronic rhinosinusitis nasal polyps (CRSwNP).Eighty treated mometasone-furoate 200 μg BID for CRSwNP followed at...
The aim of our study was to analyze the montelukast effectiveness in improving oculonasal symptoms, patient-reported outcomes (PROs), and eosinophilic biomarkers patients with nonallergic rhinitis syndrome (NARES).We enrolled prospectively 80 symptomatic treated 10 mg once a day monotherapy for 2 months. All were investigated before after treatment. Nasal symptoms (nasal obstruction, rhinorrhoea, sneezing, nasal itching), ocular (redness/puffiness, watery eyes), other PROs (olfactory...
Abstract Objectives Tinnitus is a common symptom largely impactful on quality of life, especially in the elderly. Our aim was to evaluate efficacy self‐administered screening tests correlate severity subjective perception tinnitus with emotional disorders and overall cognitive status. Methods Patients aged ≥ 55 years chronic were recruited submitted complete audiological evaluation; Handicap inventory (THI); Hospital Anxiety Depression Scale (HADS‐A HADS‐D) Mini‐Mental State Examination...
Head and neck cancer (HNC) patients require specialized care throughout the continuum of diagnosis, treatment, survival. Cooperation between ENT dentists is crucial, since all different anatomic areas affected by have distinctive characteristics best results in terms life expectancy patients' quality can only be achieved through a multidisciplinary approach. The synergic cooperation health workers early diagnosis HNC allows better prognosis for such patients. As soon as diagnose Potentially...
The treatment of choice for tumors located in the parotid gland is surgery. Nevertheless, postoperative complications are not infrequent. Regardless type surgical procedure, most common complication Frey's syndrome (FS). Traditionally, FS includes unilateral gustatory sweating and flushing facial skin lining compartment. Recent research describes atypical discomfort associated with FS. aim this study was to assess late prevalence severity both usual symptoms after parotidectomy benign...
Abstract Background Salvage total laryngectomy (TL) and laryngopharyngectomy (LP) after chemoradiotherapy may produce disfiguring defects with severe complications that require complex reconstructions. Methods Between January 2012 December 2018, we enrolled 25 patients who underwent internal mammary artery perforator (IMAP) flap reconstruction salvage TL or LP. We performed retrospective review of clinical charts to collect information such as history, timing reconstruction, type defect,...
Background: The aim of this study was to assess diagnostic accuracy and reliability narrow band imaging (NBI) in the differential diagnosis laryngeal premalignant lesion, early cancers recurrences. Material methods: We enrolled 231 patients who underwent endoscopic examination with white light endoscopy (WLE) + NBI divided them into two groups, group A, without previous radiochemotherapy B, radiochemotherapy. When indicated, we performed surgical biopsies evaluate sensitivity, specificity,...
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common disease of the nose and paranasal sinuses important economic sanitary burdens, as well having great impact on patients' quality life. In this field, new therapeutic approach for those patients who have been described affected by severe uncontrolled CRSwNP, resistant to medical best surgical treatment, represented subcutaneous human monoclonal antibodies (including dupilumab) that block specific targets involved in type 2...
Background: the primary end point of our study was to define risk factors and identify underlying conditions that may have led abuse vasoconstrictors in rhinitis medicamentosa.Moreover, we analysed influence discontinuation.Methodology: this a prospective case-control observational study.Cases controls were evaluated at baseline order influenced onset medicamentosa.They re-evaluated 3 months verify symptoms control drug discontinuation.Finally, they underwent phone call questionnaire after...