A5043020703- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Sinusitis and nasal conditions
- Cell Adhesion Molecules Research
- Allergic Rhinitis and Sensitization
- Cytokine Signaling Pathways and Interactions
- Dialysis and Renal Disease Management
- Microbial infections and disease research
- Nasal Surgery and Airway Studies
- Sepsis Diagnosis and Treatment
- Chemokine receptors and signaling
- Syphilis Diagnosis and Treatment
- Seismology and Earthquake Studies
- Cutaneous lymphoproliferative disorders research
- Pituitary Gland Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Medication Adherence and Compliance
- Reproductive tract infections research
- Retinoids in leukemia and cellular processes
- Inhalation and Respiratory Drug Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Istituti di Ricovero e Cura a Carattere Scientifico
1997-2025
Università Cattolica del Sacro Cuore
2023-2025
Agostino Gemelli University Polyclinic
2023
San Gallicano Hospital
1997-2000
GTx (United States)
1999
IRCCS Policlinico San Donato
1997-1999
Abstract Purpose Nowadays, several efficacious biologic drugs are used for severe asthma with or without chronic rhinosinusitis nasal polyps (CRSwNP). However, it has been observed that not all comorbid patients (asthma/CRSwNP) receiving treatment experience satisfactory control of both conditions equally. Methods We selected 20 who had and CRSwNP under biological benralizumab, omalizumab mepolizumab adequate but inadequate symptoms. Patients were switched to dupilumab outcomes evaluated at...
Chronic rhinosinusitis with nasal polyps (CRSwNP) may have a heterogeneous response to medical/surgical treatments based on endotypes. Data correlating biomarkers and severity of the disease are lacking. We aimed determine if IL-5 calprotectin be useful in defining identifying uncontrolled patients.
The aim of this study was to evaluate the clinical relevance absolute eosinophil blood count and by nasal cytology in context real-life practice determine if they correlate with severity symptoms patients chronic rhinosinusitis polyps (CRSwNP). We enrolled 425 CRSwNP followed between January 2015 April 2023 at A. Gemelli Hospital Foundation-IRCCS, Rome, Italy. gathered data on local correlated results features. All underwent endoscopy, Visual Analogical Scale (VAS) for main symptoms,...
ABSTRACT Objective The aim of this study was to evaluate if dupilumab interval dose de‐escalation every 4 weeks negatively impacts treatment outcomes in real‐life practice for severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) during the first 2 years treatment. Methods We enrolled 148 patients who completed follow‐up. compared two homogenous groups terms severity: group A included 77 never modified administration follow‐up; B 71 extended dosing monthly administration. and...
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disease that significantly impacts patients' quality of life. New therapeutic strategies and in particular biologic treatments are now available for these patients. It has been demonstrated Dupilumab (an anti IL-4/IL-13 drug) effective reducing the size improving symptoms thus, No real-world studies examining Dupilamab's efficacy elderly respect to other adult age groups have as yet carried out. The aim this multicentric...
Abstract Aim The present report analyzes the serum levels of three cytokines, interleukin‐6 (IL‐6), tumor necrosis factor‐alpha (TNF‐alpha) and interleukin‐10 (IL‐10) in 15 patients with bullous pemphigoid (BP) (compared 20 healthy controls) to evaluate a possible involvement these biological modulators clinical expression this disease. Background BP is rare, disease autoimmune origin evidence inflammatory processes that cause skin lesions local increase various pro‐inflammatory mediators....
Abstract Aim The present report analyzes the serum levels of three cytokines, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) in 15 patients with bullous pemphigoid (BP) (compared 20 healthy controls) to evaluate a possible involvement these biological modulators clinical expression this disease. Background BP is rare, disease autoimmune origin evidence inflammatory processes that cause skin lesions local increase various pro-inflammatory mediators....
Tryptase and myeloperoxidase respectively represent 2 specific markers of activated mast cells or neutrophils. Therefore, establishing the levels these enzymes may be useful to quantify cell involvement in tissues fluids different origins pathologies. The aim this study was analyse both sera blister patients affected with bullous pemphigoid. These were then correlated concentrations 19 cytokines soluble adhesion molecules determined same samples also log (anti-basement membrane zone...
Abstract: This study analyzes both the blister fluid (BF) and serum levels of IL‐7 TGF‐beta 1 in samples from 18 patients affected with bullous pemphigoid (BP). These cytokines clearly present lower concentrations ( P <0.001) BFs than sera (1/20 1/2, respectively). In contrast, TNF‐alpha, IL‐10 IL‐4 increased amounts that were 12, 12 17‐fold, respectively. Eighteen (and 10 suction BF) normal individuals also employed as control. Normal presented significantly BP, while no significant...
Soluble E (sE)-selectin represents the soluble isoform of cellular E-selectin, an adhesion molecule synthesized only by endothelial cells. As a consequence, it may be considered marker activity. The aim this study was therefore to evaluate serum levels sE-selectin in nine patients affected with pemphigus vulgaris (PV) and 15 bullous pemphigold (BP). Higher amounts sE-selectin, median 40.3 ng/mL, range 30-109.6 were found when compared 20 healthy individuals, 28.5 6.4-48; P < 0.01, matched...