A5073967052- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Sinusitis and nasal conditions
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Cardiovascular Effects of Exercise
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Neonatal Respiratory Health Research
- Kidney Stones and Urolithiasis Treatments
- Reproductive System and Pregnancy
- Gastroesophageal reflux and treatments
- Cancer, Lipids, and Metabolism
- Neonatal Health and Biochemistry
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Nosocomial Infections in ICU
- IL-33, ST2, and ILC Pathways
- Venous Thromboembolism Diagnosis and Management
- Acute Kidney Injury Research
- Sperm and Testicular Function
- Pregnancy and Medication Impact
- Erythrocyte Function and Pathophysiology
- Long-Term Effects of COVID-19
- Blood Pressure and Hypertension Studies
Università Cattolica del Sacro Cuore
2011-2025
Agostino Gemelli University Polyclinic
2015-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2024
Azienda Ospedaliera Universitaria Pisana
2024
Azienda Ospedaliero Universitaria Ospedali Riuniti
2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2024
University of Siena
2016-2023
University of Padua
2023
Azienda Ospedaliero Universitaria San Giovanni Battista
2018
Catholic University of America
2014-2015
Chronic rhinosinusitis with nasal polyps (CRSwNP) may have a heterogeneous response to medical/surgical treatments based on endotypes. Data correlating biomarkers and severity of the disease are lacking. We aimed determine if IL-5 calprotectin be useful in defining identifying uncontrolled patients.
Abstract Background Preterm infants are at high risk for retinopathy of prematurity (ROP), with potential life-long visual impairment. Low fetal hemoglobin (HbF) levels predict ROP. It is unknown if preventing the HbF decrease also reduces Methods BORN an ongoing multicenter double-blinded randomized controlled trial investigating whether transfusing HbF-enriched cord blood-red blood cells (CB-RBCs) instead adult donor-RBC units (A-RBCs) incidence severe ROP (NCT05100212). Neonates born...
Abstract Objectives The primary end point of this study was to evaluate the impact bile acids on severity laryngo‐pharyngeal reflux (LPR) and possible correlation with esophagitis upper airway malignancies. second if salivary molecules other than pepsin might serve as diagnostic biomarkers LPR. Design Observational prospective comparative study. Setting Otorhinolaryngology unit a tertiary hospital. Participants Sixty‐two consecutive adult outpatients suspected Main outcome measures Bile...
Neonatal respiratory distress syndrome is associated with intrahepatic cholestasis of pregnancy, and bile acids may play a major role in neonatal acid pneumonia. Our aim was to demonstrate the presence bronchoalveolar lavage fluid neonates affected by who were born from pregnancy investigate mechanisms action acute lung injury.In this prospective study, we enrolled 10 delivered requiring mechanical ventilation (intrahepatic group) 2 control groups. The first group consisted 20 infants...
The complex pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP) generates a spectrum phenotypes wide variety inflammatory states. We enrolled 44 very-likely-to-be type 2 CRSwNP patients in order to evaluate the load inflammation and analyze human interleukins secretion. Clinical data were collected severity disease. High levels IL-5, IL-4, IL-6, IL-33 detected all patients. By analyzing cytokine profiles local eosinophil count, we identified two coherent clusters: first was...
Background/Objectives: Benralizumab is a monoclonal antibody that targets the interleukin-5 receptor (IL-5Rα), leading to rapid depletion of blood eosinophils. RCTs have demonstrated efficacy in patients with severe eosinophilic asthma (SEA). The aim this study was assess benralizumab on sinonasal outcomes real-life setting SEA and concomitant chronic rhinosinusitis nasal polyps (CRSwNP). Methods: We included 25 (mean age: 57.47 years, range: 35–77, F/M = 12:13) who were prescribed 30 mg...
Background The aim of the present study was to measure eotaxin‐3 (CCL26) and eotaxin‐2 (CCL24) in nasal lavage fluid patients with different forms chronic sinonasal eosinophilic inflammation evaluate their role pathophysiology hypereosinophilia. Methods an analytic cross‐section study, level evidence 3b. Patients (n = 80) hypereosinophilia were randomly recruited grouped following categories: persistent allergic rhinitis (AR) 25), nonallergic eosinophilia syndrome (NARES) 30), rhinosinusitis...
Background The aim of the present study was to measure levels granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) in nasal lavage patients affected by chronic eosinophilic sinonasal inflammation clarify relationship with tissue infiltration and clinical features. Methods Between November 2012 June 2013, we selected 70 (average age 41.8 years) who were classified into following groups: persistent allergic rhinitis (group 1), noninfectious non‐allergic eosinophilia syndrome 2)...
<b><i>Background:</i></b> Recent evidence indicates that a systemic state of inflammation may impair fertility, but data about psoriatic males are scarce. <b><i>Objectives:</i></b> The aim this study was to assess gonadal function in implementing our knowledge fertility these subjects. <b><i>Methods:</i></b> Male patients, aged between 18 and 55 years, group healthy subjects matched for age, BMI geographic origin were...
Background We evaluated the prognostic value of nasal cytology and clinical factors in predicting polyp (NP) development patients with history nonallergic chronic sinonasal inflammation. Methods This was a retrospective case‐control study 295 followed at our institution for mean 85.70 ± 19.41 months. According to inclusion criteria we enrolled 84 cases persistent eosinophilic inflammation (group A) 106 neutrophilic B), both without evidence NPs baseline. considered as controls 105 affected...
Background: to date, there are no specific markers available for diagnosing sepsis. Diagnosis is, indeed, mainly determined by clinical suspicion and the evaluation of patient's overall condition. This involves assessing various inflammatory markers, such as C-reactive protein (CRP) procalcitonin (PCT), along with tissue hypoxia, serum lactate. Additionally, it includes scores that account complete blood count (CBC), organ function vital parameters, including SOFA, qSOFA, SIRS, NEWS. Over...
ABSTRACT Objective This study investigated myostatin levels in SMA patients receiving disease‐modifying therapies (DMTs) to understand their relationship with treatment duration and functional status. Methods Our includes both cross‐sectional longitudinal analyses of treated patients. The cohort included 46 treatment‐naive assessed at baseline 12 months post‐treatment. Myostatin were measured using ELISA. Age‐matched controls ( n = 89) for comparison. 128 variable durations (from 0.4 7.2...
The aim of our study was to measure CCL24 (eotaxin-2) levels in nasal lavage fluid patients with different forms sinonasal chronic eosinophilic inflammation verify the relationship hypereosinophilia and symptoms.Patients were randomly recruited grouped persistent allergic rhinitis, non-allergic rhinitis eosinophilia syndrome (NARES) rhinosinusitis polyps. Non rhinitic volunteers as controls. concentration measured by `Quantikine Human Immunoassay`. Differential cell counts performed...
The estimated number of testicular olfactory receptors (ORs) in mammals range between 20 and 66. Previous data reported the role hOR17-4 mOR23 sperm-oocyte chemiotaxis. Proteomic analysis was performed to understand which are ORs expressed seminal plasma. Seminal samples by four fertile men were analyzed an Ultimate 3000Nano/Micro-HPLC apparatus coupled with LTQ-Orbitrap XL hybrid mass spectrometer. Western blot confirmed expression three identified ORs. sperm cells, testis, epididymis...
Background: Chest pain is a prevalent reason for emergency room referrals and presents diagnostic challenges. The physician must carefully differentiate between cardiac noncardiac causes, including various vascular extracardiovascular conditions. However, it crucial not to overlook serious conditions such as acute coronary syndrome (ACS). Diagnosis of myocardial infarction (AMI) early discharge management become difficult when traditional clinical criteria, ECG, troponin values are...
The aim of this study was to evaluate the clinical relevance absolute eosinophil blood count and by nasal cytology in context real-life practice determine if they correlate with severity symptoms patients chronic rhinosinusitis polyps (CRSwNP). We enrolled 425 CRSwNP followed between January 2015 April 2023 at A. Gemelli Hospital Foundation-IRCCS, Rome, Italy. gathered data on local correlated results features. All underwent endoscopy, Visual Analogical Scale (VAS) for main symptoms,...
Abstract Objectives Spontaneous subarachnoid hemorrhage (sSAH) is a life-threatening neurological event with high morbidity and mortality. Predicting patient outcomes remains challenging, necessitating novel prognostic tools. This study evaluates the value of central systemic serum biomarkers, including S100, neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP), ubiquitin carboxy-terminal hydrolase L1 (UCHL-1), soluble suppression tumorigenicity 2 (sST2), urokinase...