A5039684166- Dialysis and Renal Disease Management
- Liver Disease Diagnosis and Treatment
- Restless Legs Syndrome Research
- Muscle and Compartmental Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Parkinson's Disease Mechanisms and Treatments
- Hemodynamic Monitoring and Therapy
- Neurological disorders and treatments
- Parathyroid Disorders and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Erythrocyte Function and Pathophysiology
- Platelet Disorders and Treatments
- Blood properties and coagulation
- Pharmacological Effects and Toxicity Studies
- Hemoglobin structure and function
- Cardiac, Anesthesia and Surgical Outcomes
- Botulinum Toxin and Related Neurological Disorders
- Vitamin D Research Studies
- Blood Pressure and Hypertension Studies
- Diabetes and associated disorders
- Liver Disease and Transplantation
- Neonatal Health and Biochemistry
- Psychosomatic Disorders and Their Treatments
Agostino Gemelli University Polyclinic
2015-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2025
Università Cattolica del Sacro Cuore
2016-2025
Centre Hospitalier Universitaire de Grenoble
2021
Université Grenoble Alpes
2021
Inserm
2021
University of Modena and Reggio Emilia
2021
University of Milan
2006-2021
University Hospital of Bern
2021
University of the Sacred Heart
2009-2021
Hepatitis C virus (HCV) is a major human pathogen causing chronic liver disease. We have recently found that the large extracellular loop (LEL) of CD81 binds HCV. This finding prompted us to assess structure-function features HCV-CD81 interaction by using recombinant E2 protein and soluble form LEL. HCV-E2 LEL with K d 1.8 nM; can mediate attachment on hepatocytes; engagement mediates internalization only 30% molecules even after 12 h; four cysteines two disulfide bridges, integrity which...
Image-guided laser ablation therapy (LAT) of benign thyroid nodules demonstrated favorable results in randomized trials with fixed modalities treatment. The aim this retrospective multicenter study was to assess the effectiveness, tolerability, and complications LAT a large consecutive series patients from centers using technique their routine clinical activity. Clinical records 1534 laser-treated 1531 eight Italian referral were assessed. Inclusion criteria as follows: solid or mixed fluid...
OBJECTIVE We investigated whether supplementation of the active form vitamin D (calcitriol) in recent-onset type 1 diabetes can protect β-cell function evaluated by C-peptide and improve glycemic control assessed A1C insulin requirement. RESEARCH DESIGN AND METHODS Thirty-four subjects (aged 11–35 years, median 18 years) with high basal >0.25 nmol/l were randomized a double-blind trial to 0.25 μg/day calcitriol or placebo followed-up for 2 years. RESULTS At 6, 12, 24 months follow-up,...
The aim of the present trial on ultrasound (US)-guided laser ablation therapy (LAT) solid thyroid nodules is to assess long-term clinical efficacy, side effects, and predictability outcomes in different centers operating with same procedure.Two hundred consecutive patients were randomly assigned a single LAT session (group 1, 101 cases) or follow-up 2, 99 at four referral centers. Entry criteria were: nodule volume 6-17 mL, repeat benign cytological findings, normal function, no...
Purpose: To compare technique efficacy and safety of laser ablation (LA) radiofrequency (RFA) in treatment benign thyroid nodules.Materials methods: Institutional review board approval was obtained, patients' consent waived. 601 nodules were treated from May 2009 to December 2014 at eight centres, 449 (309 females, age 57 ± 14 years) with LA 152 (107 RFA. A matched cohort composed 138 patients each group selected after adjustment propensity score matching. Factors influencing volume...
To evaluate the effects of deep brain stimulation subthalamic nucleus (STN-DBS) on motor complications in patients with Parkinson disease (PD) beyond 15 years after surgery.Data complications, quality life (QoL), activities daily living, Unified Parkinson's Disease Rating Scale scores, dopaminergic treatment, measures, and side STN-DBS were retrospectively retrieved compared before surgery, at 1 year, bilateral STN-DBS.Fifty-one 17.06 ± 2.18 follow-up recruited. Compared to baseline, time...
Background: Single-center trials demonstrated moderate-substantial level of interobserver agreement in the evaluation ultrasound (US) features thyroid nodules. Multicenter studies on US agreement, however, are scanty, and data intraobserver poor. Aim study was to assess inter- between different centers specialists. Methods: A blinded analysis 100 electronically recorded nodule images conducted three large-volume by seven radiologists endocrinologists. The repeated after randomization 4...
Background/Objectives: Over the course of end-stage renal disease, patients undergoing hemodialysis (HD) often face significant psychological distress. Nonetheless, little is known about perceived stress levels and related factors in HD patients. This a cross-sectional study that explores prevalence associated variables Methods: Participants included 223 recruited June 2024 Italy. Perceived depression were measured with Stress Scale (PSS) Beck Depression Inventory (BDI-II). We also collected...
ABSTRACT Introduction This study explored the relationship between post dialysis fatigue (PDF) and recovery time (DRT) with perceived stress depression. Methods A cross‐sectional was conducted on 223 patients hemodialysis (HD). We collected demographic, laboratory clinical variables [including depression levels measured Perceived Stress Scale (PSS) Beck Depression Inventory (BDI‐II)] to explore their association PDF DRT. Findings Of total, 120 suffered 103 did not. Groups differed in...
Abstract Background A number of recent studies underline the importance vitamin D in pathogenesis Type 1 diabetes (T1D). Aims The aim this study was to investigate whether supplementation with active form (calcitriol) subjects recent‐onset T1D protects residual pancreatic β‐cell function and improves glycaemic control (HbA 1c insulin requirement). Methods In open‐label randomized trial, 70 T1D, mean age 13.6 years ± 7.6 sd were calcitriol (0.25 µg on alternate days) or nicotinamide (25 mg/kg...
Purpose To evaluate the diagnostic accuracy of shear-wave elastography (SWE) in identifying different degrees fibrosis a cohort consecutive children and adolescents with nonalcoholic steatohepatitis (NASH). Materials Methods Consecutive pediatric patients scheduled to undergo liver biopsy were studied an ultrasonography-based SWE system. Elastography was performed 68 69 biopsy-proved NASH (37 boys 31 girls; mean age, 12.6 years ± 2.48; age range, 8–17 years). The correlations among...
Abstract Introduction Acute kidney injury (AKI) is a common complication among hospitalized patients. The aim of this study was to evaluate the utility blood neutrophil gelatinase-associated lipocalin (NGAL) assessment as an aid in early risk evaluation for AKI development admitted Methods This multicenter Italian prospective emergency department (ED) cohort which we enrolled 665 patients hospital from ED. Results Blood NGAL and serum creatinine (sCr) were determined at ED presentation (T0),...
British Thyroid Association (BTA), American (ATA), and of Clinical Endocrinologists (AACE/ACE/AME) recommend for thyroid nodules an ultrasound (US)-based stratification risk malignancy. Aim our study was to assess the diagnostic accuracy US classification systems their reliability indication fine-needle aspiration (FNA). Prospective on 987 consecutively referred FNA. images were independently reviewed by four experts assignment malignancy risk. Cytologically benign had confirmation with a...