A5111885860- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Antifungal resistance and susceptibility
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Antimicrobial Resistance in Staphylococcus
- Bacterial Infections and Vaccines
- Long-Term Effects of COVID-19
- Fungal Infections and Studies
- Antibiotic Use and Resistance
- Sepsis Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Bacterial Identification and Susceptibility Testing
- Immunodeficiency and Autoimmune Disorders
- Tuberculosis Research and Epidemiology
- HIV/AIDS Impact and Responses
- Drug-Induced Adverse Reactions
- Antibiotic Resistance in Bacteria
- HIV/AIDS Research and Interventions
- Viral-associated cancers and disorders
- Streptococcal Infections and Treatments
- Immune Cell Function and Interaction
- Polyomavirus and related diseases
- Infectious Diseases and Tuberculosis
- HIV-related health complications and treatments
Turnitin (United States)
2024
Polytechnic University of Turin
2023
Corvid Technologies (United States)
2023
Università Cattolica del Sacro Cuore
1995-2020
Agostino Gemelli University Polyclinic
2015-2020
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2020
Fundação Oswaldo Cruz
2008
Universidade de São Paulo
2008
Office of Infectious Diseases
1997
Coinfections with bacteria or fungi may be a frequent complication of COVID-19, but coinfections Candida species in COVID-19 patients remain rare. We report the 53-day clinical course complicated type-2 diabetes patient diagnosed who developed bloodstream infections initially due to methicillin-resistant Staphylococcus aureus, secondly multidrug-resistant Gram-negative bacteria, and lastly possibly fatal glabrata. The development FKS-associated pan-echinocandin resistance C. glabrata...
Nutritional status is a critical factor throughout COVID-19 disease course. Malnutrition associated with poor outcomes in hospitalized patients.
Abstract. The integration of Building Information Modeling (BIM), or Historic BIM (HBIM), and Geographic Systems (GIS) has assumed a crucial role not only in the management smart cities urban districts, as well construction sector infrastructures but also management, conservation safeguarding cultural heritage. This opens up new opportunities for decision-makers to assess impact interventions on heritage sites, evaluate preservation strategies, facilitate informed decision-making processes....
The novel coronavirus SARS-Cov-2 can infect the respiratory tract causing a spectrum of disease varying from mild to fatal pneumonia, and known as COVID-19. Ongoing clinical research is assessing potential for long-term sequelae in these patients. We assessed function cohort patients after recovering infection, stratified according PaO2/FiO2 (p/F) values.Approximately one month hospital discharge, 86 COVID-19 underwent physical examination, arterial blood gas (ABG) analysis, pulmonary tests...
Coinfections with bacteria or fungi may be a frequent complication of COVID-19, although coinfections Candida species in COVID-19 patients remain rare. We report the 53-day clinical course complicated type-2 diabetes patient diagnosed who developed bloodstream infections initially due to methicillin-resistant Staphylococcus aureus, secondly multidrug-resistant Gram-negative bacteria, and lastly possibly fatal glabrata. Development FKS-associated pan-echinocandin resistance C. glabrata...
DNA amplification by the polymerase chain reaction (PCR) is a promising method for detection of Pneumocystis carinii in immunosuppressed patients. The sensitivity and specificity PCR technique has been assessed comparison with immunofluorescence (IF) on bronchoalveolar lavage fluid (BALF). Results correlated 43 (78.8%) 52 cases studied. P. gave positive results BALF from all 32 patients found to have pneumonia (PCP); IF 26 them. was more sensitive as specific IF. However, at present time, we...
Sepsis is a life-threatening disease resulting from the interaction between pathogen and host response; its dysregulation causes organ dysfunction, high morbidity, mortality. Despite increase of septic patients admitted to Internal Medicine wards, data about clinical predictors mortality in this setting are still lacking. The aim study was evaluate role MEDS score vitamin D as (28-day 90-day) department.Prospectively collected data, lab tests including D, scores (SIRS, MEDS, SCS, REMS, SOFA,...
Among 4,023 HIV-infected patients admitted to a large Italian university hospital in the period 1985-1996, 14 had concomitant HIV and bacterial osteoarticular infections. Staphylococcus aureus infections were commonest diagnosed 8 patients. Intravenous drug addiction was only risk factor significantly associated with development of infection (p = 0.04). In contrast, no statistical correlations found age, sex, absolute number circulating T-CD4+ lymphocytes, neutrophils stage infection....
The present study compared the effects of early short-term with prolonged low-dose corticosteroid therapy in acute lung injury (ALI). In total, 120 BALB/c mice were randomly divided into five groups. control group, saline was intratracheally ( i.t. ) instilled. ALI received Escherichia coli lipopolysaccharide (10 μg ). animals further randomised four subgroups to receive (0.1 mL i.v. or methylprednisolone (2 mg·kg −1 at 6 h, 24 h daily (for 7 days, beginning day 1). At 1, 3 and 8 weeks, vivo...
Abstract Background Neurological manifestations of Sars-CoV-2 infection have been described since March 2020 and include both central peripheral nervous system manifestations. symptoms, such as headache or persistent loss smell taste, also documented in COVID-19 long-haulers. Moreover, long lasting fatigue, mild cognitive impairment sleep disorders appear to be frequent term neurological after hospitalization due COVID-19. Less is known relation nerve injury related infection. Case...
Objectives: To assess the performance of (1,3)-β-D-glucan (BDG) detection assay in a large cohort patients with suspected candidemia who were admitted to non-intensive care unit hospital wards. Methods: This observational, retrospective study was conducted 1,100-bed university Rome, where an infectious disease consultation team has been operational. Two groups included analysis: Group 1, Candida bloodstream infection (BSI) had at least one BDG test performed ±48 hours from first positive...
Objectives: To describe a rapid workflow based on the direct detection of Escherichia coli (Ec) and Klebsiella pneumoniae (Kp) producing CTX-M extended-spectrum β-lactamase (ESBL) and/or carbapenemases (eg, KPC, VIM) from blood cultures (BCs) infectious disease (ID) consulting for timely appropriate antimicrobial therapy. Methods: This observational, retrospective study included adult patients with first episode Ec or Kp bloodstream infection (BSI) in large Italian university hospital, where...
Background: Clostridium difficile infection (CDI) is characterized by a relevant intestinal neutrophil infiltrate. So far, role of fecal calprotectin in CDI, has been investigated only few studies, mainly focused on diagnosis the disease.Aim: By longitudinal design, we assess concentrations (FCCs) subjects with evaluating correlation between marker and response to therapy.Methods: Clinical (diarrhea scoring) laboratory (FCCs leucocytes count) evaluation was performed 56 CDI at time (T0)...
To evaluate whether PCT levels could be used to distinguish among different bacterial and fungal etiologies in patients with documented bloodstream infection (BSI).Monocentric retrospective cohort study on admitted the Fondazione Policlinico Gemelli Hospital between December 2012 November 2015 BSI. Those who had undergone determination within 48 hours of when first positive blood culture was sampled were included study.Four hundred one study. Both 24h 48h values significantly higher...
To assess epidemiological features of patients for which a consultation by the infectious diseases team was required, and rate clinical advice that led to resource-saving (R-SA): discontinuation inappropriate therapy or prophylaxis, de-escalation switch from parenteral oral therapy.An implemented in 1100-bed university hospital Italy.The most frequent infections an consultancy required were pneumonia, bloodstream (17% Candida) urinary tract infections. In 828 (41.4%), interventions with...