A5065323385- RNA modifications and cancer
- Soybean genetics and cultivation
- Bioenergy crop production and management
- Cancer Genomics and Diagnostics
- Plant Stress Responses and Tolerance
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Plant Molecular Biology Research
- Ferroptosis and cancer prognosis
- Plant Physiology and Cultivation Studies
- Plant nutrient uptake and metabolism
- Legume Nitrogen Fixing Symbiosis
- Plant Reproductive Biology
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Bioinformatics and Genomic Networks
- Acute Myeloid Leukemia Research
- Biofuel production and bioconversion
- Plant responses to water stress
- Biochemical and biochemical processes
- Aquaculture disease management and microbiota
- Chronic Myeloid Leukemia Treatments
Indiana University – Purdue University Indianapolis
2023-2025
Prevention Institute
2023-2025
Indiana University School of Medicine
2024-2025
Institute of Genetics and Developmental Biology
2016-2025
Chinese Academy of Sciences
2016-2025
University of Chinese Academy of Sciences
2019-2025
Texas A&M University
2023-2024
Fujian Medical University
2020-2024
Union Hospital
2020-2024
State Key Laboratory of Plant Genomics
2016-2023
Dinoflagellates are important components of marine ecosystems and essential coral symbionts, yet little is known about their genomes. We report here on the analysis a high-quality assembly from 1180-megabase genome Symbiodinium kawagutii. annotated protein-coding genes identified Symbiodinium-specific gene families. No whole-genome duplication was observed, but instead we found active (retro)transposition family expansion, especially in processes for successful symbiosis with corals. also...
The use of alkaline salt lands for crop production is hindered by a scarcity knowledge and breeding efforts plant tolerance. Through genome association analysis sorghum, naturally high-alkaline-tolerant crop, we detected major locus, Alkaline Tolerance 1 (AT1), specifically related to alkaline-salinity sensitivity. An at1 allele with carboxyl-terminal truncation increased sensitivity, whereas knockout AT1 tolerance alkalinity in millet, rice, maize. encodes an atypical G protein γ subunit...
Cultivated soybean [Glycine max (L.) Merr.] is a primary source of vegetable oil and protein. We report landscape analysis genome-wide genetic variation an association study major domestication agronomic traits in soybean. A total 106 genomes representing wild, landraces, elite lines were re-sequenced at average 17x depth with 97.5% coverage. Over 10 million high-quality SNPs discovered, 35.34% these have not been previously reported. Additionally, 159 putative sweeps identified, which...
Abstract Proteolysis-targeting chimera (PROTAC) and other targeted protein degradation (TPD) molecules that induce by the ubiquitin-proteasome system (UPS) offer new opportunities to engage targets remain challenging be inhibited conventional small molecules. One fundamental element in process is E3 ligase. However, less than 2% amongst hundreds of ligases human genome have been engaged current studies TPD field, calling for recruiting additional ones further enhance therapeutic potential...
Abstract Background Recently, many studies utilizing next generation sequencing have investigated plant evolution and domestication in annual crops. Peach, Prunus persica , is a typical perennial fruit crop that has ornamental edible varieties. Unlike other crops, cultivated peach includes large number of phenotypes but few polymorphisms. In this study, we explore the genetic basis influence humans on its evolution. Results We perform large-scale resequencing 10 wild 74 varieties, including...
Zea mays is an important crop that sensitive to drought stress, but survival rates and growth status remain strong in some drought-tolerant lines under stress conditions. Under conditions, many biological processes, such as photosynthesis, carbohydrate metabolism energy metabolism, are suppressed, while little known about how the transcripts of genes respond genome-wide rang seedling stage. In our study, transcriptome profiles two maize recombination inbred (drought-tolerant RIL70...
Alzheimer’s disease (AD) is the leading dementia among elderly with complex origins. Despite extensive investigation into AD-associated protein-coding genes, involvement of noncoding RNAs (ncRNAs) and posttranscriptional modification (PTM) in AD pathogenesis remains unclear. Here, we comprehensively characterized landscape ncRNAs PTM events 1460 samples across six brain regions sourced from Mount Sinai/JJ Peters VA Medical Center Brain Bank Study Mayo cohorts, encompassing 33,321 long...
Abstract One of the most critical steps in cereal threshing is ease with which seeds are detached from sticky glumes. Naked grains low glume coverage have dramatically increased efficiency and seed quality. Here, we demonstrate that GC1 ( Glume Coverage 1 ), encoding an atypical G protein γ subunit, negatively regulates sorghum coverage. Naturally truncated variations C-terminus accumulate at higher levels affect stability a patatin-related phospholipase SbpPLAII-1. A strong positive...
Sweet sorghum is a C4 crop that can be grown for silage forage, fiber, syrup and fuel production. It generally considered salt-tolerant plant. However, the salt tolerance ability varies among genotypes, mechanism not well known. To further uncover mechanism, we performed comparative transcriptome analysis with RNA samples in two sweet genotypes showing different abilities (salt-tolerant line RIO salt-sensitive SN005) upon treatment. These response processes mainly focused on secondary...
<div>Abstract<p>Systematic multiomic analysis has revealed ancestry-dependent molecular alterations, but their impact on the efficacy of anticancer treatment is yet largely unknown. In this study, we analyzed clinical trials from ClinicalTrials.gov and found that only 8,779/102,721 (8.5%) oncology posted information enrollment by race/ethnicity. The underrepresentation non-White populations suggests it remains challenging to determine differences in antitumor treatments among...
<p>Supplementary Fig. S1. The underrepresentation of Hispanic or Latino populations in clinical trials. (A) summary all trials Clinical Trials obtained on March 24, 2024. (B-C) Latino, non-Hispanic individuals different phases (B) and (C) years. Supplementary S2. multi-omics molecular variations clinically actionable genes. number alterations genes across ancestries. difference EGFR mutation frequency White vs. Asian patients with NSCLC. sample sizes racial 23 metastatic cancer types...
Due to climate change, drought has become a severe abiotic stress that affects the global production of all crops. Elucidation complex physiological mechanisms underlying tolerance in crops will support cultivation new drought-tolerant crop varieties. Here, two lines, RIL70 and RIL73, drought-sensitive RIL44 RIL93, from recombinant inbred lines (RIL) generated maize line PH4CV F9721, were selected for comparative RNA-seq study. Through transcriptome analyses, we found gene expression...
Abstract Proteomics is a powerful approach that can rapidly enhance our understanding of cancer development. Detailed characterization the genetic, pharmacogenomic, and immune landscape in relation to protein expression patients with could provide new insights into functional roles proteins cancer. By taking advantage genotype data from The Cancer Genome Atlas Proteome Atlas, we characterized effects genetic variants on across 31 types identified approximately 100,000 quantitative trait loci...
To reduce the world's reliance on traditional fossil fuels, alternative fuel sources are being developed. The most common renewable today is ethanol. Sweet sorghum has been developed as a potential source for bioethanol production. Comparing to other energy plants, sweet provides high biomass yield, sugar/ethanol and ability grow marginal land areas. economic cost of growing harvesting its fermentable carbohydrate also analysed found favourable compared that maize. Future studies genetics...
Abstract Expression quantitative trait locus (eQTL) analysis is a powerful tool used to investigate genetic variations in complex diseases, including cancer. We previously developed comprehensive database, PancanQTL, characterize cancer eQTLs using The Cancer Genome Atlas (TCGA) dataset, and linked with patient survival GWAS risk variants. Here, we present an updated version, PancanQTLv2.0 (https://hanlaboratory.com/PancanQTLv2/), advancements fine-mapping causal variants for eQTLs, updating...
Objective: To analyze the clinical characteristics and prognosis of adult T cell leukemia/lymphoma (ATLL). Methods: Peripheral blood samples from patients who were suspected as ATLL March, 2013 to July, 2015, collected for HTLV-1 provirus genes detection in genomic DNA extraction by PCR. Cases showing positive results confirmed ATLL. Clinical laboratory characteristics, therapeutic outcomes survival evaluation collected. Results: 12 out 23 confirmedly diagnosed through Eight male four...
Our study charts a global landscape of ancestry-associated differences in therapeutic efficacy, highlighting the importance considering ancestry anticancer therapies.
To analyze the clinical characteristics and prognosis of children with hypodiploid B-cell precursor acute lymphoblastic leukemia (BCP-ALL).