A5078703807- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Helicobacter pylori-related gastroenterology studies
- Hepatitis B Virus Studies
- Psoriasis: Treatment and Pathogenesis
- Liver Disease Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cytokine Signaling Pathways and Interactions
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Wnt/β-catenin signaling in development and cancer
- Ethics in Clinical Research
- Galectins and Cancer Biology
- Gallbladder and Bile Duct Disorders
- Liver physiology and pathology
- Kruppel-like factors research
- Ferroptosis and cancer prognosis
National Engineering Research Center for Nanotechnology
2008-2024
Shandong Provincial Hospital
2020-2024
Shandong First Medical University
2022-2024
Tongji Hospital
2009-2023
Tongji University
2010-2023
Shanghai Center For Bioinformation Technology
2011-2023
Shandong University
2022
Chinese National Human Genome Center
2013
Changhai Hospital
2008
Second Military Medical University
2008
Background Centromere protein A (CENP-A) plays important roles in cell-cycle regulation and genetic stability. Herein, we aimed to investigate its expression pattern, clinical significance, biological function hepatocellular carcinoma (HCC). Methodology/Principal Findings CENP-A at the mRNA levels was examined 20 pairs of fresh HCCs corresponding nontumor liver tissues. Immunohistochemistry for performed on 80 paraffin-embedded HCC specimens, significance analyzed. human cell line HepG2 with...
Although Argonaute proteins are considered to play important roles in stem cell self-renewal, RNA interference (RNAi) and translational regulation, relatively little is known about their functions human disease. In this study, we investigated the expression of eight members family colon cancer identified potential tumor development progression. Antibodies against were prepared by immunizing rabbits with synthetic peptides derived from sequences members. Then constructed a tissue microarray...
Abstract Background To elucidate gene expression associated with copy number changes, we performed a genome-wide and microarray analysis of 25 pairs gastric tissues. Methods We applied laser capture microdissection (LCM) to obtain samples for experiments profiled DNA using 244K CGH Microarray Human Exon 1.0 ST Microarray. Results Obviously, gain at 8q was detected the highest frequency (70%) 20q second (63%). also identified molecular genetic divergences different TNM-stages or histological...
5-Hydroxytryptamine (5-HT), a neurotransmitter and vasoactive factor, has been reported to promote proliferation of serum-deprived hepatocellular carcinoma (HCC) cells but the detailed intracellular mechanism is unknown. As Wnt/β-catenin signalling highly dysregulated in majority HCC, this study explored regulation by 5-HT. The expression various 5-HT receptors was studied quantitative real-time polymerase chain reaction (qPCR) HCC cell lines as well 33 pairs tumours corresponding adjacent...
Exosomes assume a pivotal role as essential mediators of intercellular communication within tumor microenvironments. Within this context, long noncoding RNAs (LncRNAs) have been observed to be preferentially sorted into exosomes, thus exerting regulatory control over the initiation and progression cancer through diverse mechanisms.
Background : The hepatitis B virus x gene ( HBx ) is a promiscuous transactivator implicated in the development of hepatocellular carcinoma (HCC). present study was designed to investigate molecular events regulated by . Methods Genomic and proteomic expression profiling performed Huh7 HCC cells transfected with mutants C-terminal deletion. protein wingless-type murine-mammary-tumour (MMTV) integration site family, member 5A (Wnt-5a) validated analyses reverse transcription–polymerase chain...
Cancer cell invasion and metastasis are the most important adverse prognostic factors for pancreatic cancer. Identification of biomarkers associated with outcome cancer may provide new approaches targets anticancer therapy. The aim this study is to examine relationship between expression RhoT1, Smad4 p16 survival in patients analysis showed that high cytoplasmic levels tissues had significantly negative correlation lymph node (LNM) (P = 0.017, P 0.032, 0.042, respectively). However, no...
Background: Esophageal squamous cell carcinoma (ESCC), one of the leading causes cancer mortality worldwide, is a heterogeneous with diverse clinical manifestations. However, little known about epigenetic heterogeneity and its relevance for this prevalent cancer. Methods: We generated 7.56 Tb single-base resolution whole-genome bisulfite sequencing data 84 ESCC paired paraneoplastic tissues. The analysis identified inter- intratumor DNA methylation (DNAm) heterogeneity, epigenome-wide DNAm...
associated HCC tissues in China.HBV integration had also taken place partial tissues.This supporting the hypothesis that deletion and probably integrated forms of HBx gene may be implicated liver carcinogenesis.
Background/Aims: Transforming growth factor-β 1 (TGF-β ) plays an important role in the pathogenesis of liver fibrosis and cirrhosis.Recombinant human bone morphogenic protein-7 (rhBMP-7) alleviates renal improves kidney function.However, beneficial effect BMP-7 on hepatic cirrhosis remains unknown.The purpose this study was to investigate prophylactic therapeutic effects rhBMP-7 underlying mechanisms.Methods: Liver rat model induced by peritoneal injection porcine-serum (0.5ml/kg body...