A5102754378- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Helicobacter pylori-related gastroenterology studies
- Genetic Associations and Epidemiology
- Pancreatic and Hepatic Oncology Research
- Galectins and Cancer Biology
- RNA modifications and cancer
- Genomic variations and chromosomal abnormalities
- Antimicrobial Resistance in Staphylococcus
- RNA Research and Splicing
- Renin-Angiotensin System Studies
- Autophagy in Disease and Therapy
- Hormonal Regulation and Hypertension
- Ubiquitin and proteasome pathways
- Veterinary medicine and infectious diseases
- Bioinformatics and Genomic Networks
- Nutrition, Genetics, and Disease
- Plant Disease Resistance and Genetics
- Peptidase Inhibition and Analysis
- Cytokine Signaling Pathways and Interactions
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related Molecular Pathways
- Heat shock proteins research
Peking University
2024
Nanjing Medical University
2023
Nantong University
2023
Taizhou People's Hospital
2023
Shanghai Center For Bioinformation Technology
2006-2019
National Engineering Research Center for Nanotechnology
2011-2019
Tongji University
2009-2014
Tongji Hospital
2009
Chinese National Human Genome Center
2003-2008
Ruijin Hospital
2008
Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage jaundice. In more cases, massive pulmonary haemorrhages, including fatal sudden haemoptysis, can occur1. Here we report the complete genomic sequence representative virulent serovar type strain (Lai)2 Leptospira interrogans serogroup Icterohaemorrhagiae consisting 4.33-megabase large chromosome 359-kilobase small chromosome, total...
Colorectal cancer (CRC) is one of the leading causes cancer-related death in China. Dysregulation microRNAs (miRNAs) involved development and progression. Our previous study showed an inverse relationship between miR-193a-3p expression prognosis CRC. However, exact biological functions CRC are still poorly understood. This aimed to explore role mechanism CRC.Real-time PCR Western blotting were used examine levels RNA protein, respectively. A dual luciferase assay was performed validate...
Abstract Background It is of great concern to identify prognostic signatures for the prediction and esophageal squamous cell carcinoma (ESCC), which lethal pathological type malignancy. Method Bulk RNA sequencing scRNA-seq data were retrieved from GSE53624, GSE53622, GSE188900. Disulfidptosis-related differentially expressed genes (DEGs) identified between disulfidptosis-high score disulfidptosis-low groups. Functional annotation DEGs analyzed by Gene Ontology (GO). Consistent clustering...
Human hepatocellular carcinoma (HCC) is one of the most common tumors worldwide, in which genetic mechanisms oncogenesis are still unclear. To investigate whether genomic DNA copy number alterations may contribute to primary HCC, cDNA microarray‐based comparative hybridization (CGH) analysis was here performed 41 HCC infected by hepatitis B virus and 12 cell lines. The resulting data showed that, on average, 7.25% genome‐wide numbers significantly altered those samples (4.61 ± 2.49% gained...
Cancer cell invasion and metastasis are the most important adverse prognostic factors for pancreatic cancer. Identification of biomarkers associated with outcome cancer may provide new approaches targets anticancer therapy. The aim this study is to examine relationship between expression RhoT1, Smad4 p16 survival in patients analysis showed that high cytoplasmic levels tissues had significantly negative correlation lymph node (LNM) (P = 0.017, P 0.032, 0.042, respectively). However, no...
Abstract The goal of this study was to evaluate the feasibility detecting Helicobacter pylori clarithromycin resistance in gastric mucosa using amplification refractory mutation system combined with quantitative real‐time PCR (ARMS‐PCR). Gastric mucosal specimens (150) were collected from patients who unsuccessfully treated for H. pylor i eradication. Each specimen divided into 2 samples. One sample used extract genomic DNA and detect any gene mutations H . produced by ARMS‐ PCR. Sequencing...
Epithelial-mesenchymal transition (EMT) is an early and key process in the metastatic cascade during progression of colorectal cancer (CRC). The aim present study was to identify deregulated EMT‑related microRNAs (miRNAs/miRs) CRC assess effect differentially expressed miRNAs on prognosis patients with CRC. Genome‑wide expression profiling assessed 3 EMT‑negative EMT‑positive tissues. Differentially miRNA further validated 90 pairs corresponding paracarcinoma tissues using reverse...