A5012867572- Cardiac Fibrosis and Remodeling
- Gold and Silver Nanoparticles Synthesis and Applications
- Carbohydrate Chemistry and Synthesis
- Molecular Junctions and Nanostructures
- Cell death mechanisms and regulation
- Perovskite Materials and Applications
- Plasmonic and Surface Plasmon Research
- Signaling Pathways in Disease
- Graphene research and applications
- Fatigue and fracture mechanics
- interferon and immune responses
- Graphene and Nanomaterials Applications
- RNA Research and Splicing
- Spectroscopy and Quantum Chemical Studies
- Enzyme Catalysis and Immobilization
- Advanced biosensing and bioanalysis techniques
- Quantum Dots Synthesis And Properties
- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
- Mesenchymal stem cell research
- Modular Robots and Swarm Intelligence
- Legume Nitrogen Fixing Symbiosis
- Advanced Memory and Neural Computing
- Cancer-related gene regulation
- Advanced Sensor and Energy Harvesting Materials
Northwestern Polytechnical University
2024
University of North Carolina at Chapel Hill
2022-2024
Kaili University
2012-2024
Huazhong University of Science and Technology
2023-2024
Union Hospital
2023-2024
Yanshan University
2024
MaineHealth
2024
University of North Carolina Health Care
2023
Applied Physical Sciences (United States)
2023
Chongqing University of Posts and Telecommunications
2022
Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage jaundice. In more cases, massive pulmonary haemorrhages, including fatal sudden haemoptysis, can occur1. Here we report the complete genomic sequence representative virulent serovar type strain (Lai)2 Leptospira interrogans serogroup Icterohaemorrhagiae consisting 4.33-megabase large chromosome 359-kilobase small chromosome, total...
Background: Cardiac fibroblasts (CFs) have a central role in the ventricular remodeling process associated with different types of fibrosis. Recent studies shown that do not respond homogeneously to heart injury. Because limited set bona fide fibroblast markers, proper characterization population heterogeneity response cardiac damage is lacking. The purpose this study was define CF during and underlying mechanisms regulate function. Methods: Collagen1α1–GFP (green fluorescent...
Abstract Drawing inspiration from cohesive integration of skeletal muscles and sensory skins in vertebrate animals, we present a design strategy soft robots, primarily consisting an electronic skin (e-skin) artificial muscle. These robots integrate multifunctional sensing on-demand actuation into biocompatible platform using in-situ solution-based method. They feature biomimetic designs that enable adaptive motions stress-free contact with tissues, supported by battery-free wireless module...
Experiments utilizing the Looptail mutant mouse, which harbors a missense mutation in vangl2 gene, have been essential for studies of planar polarity and linking function core cell proteins to other developmental signals. Originally described as having dominant phenotypic traits, molecular interactions underlying phenotype are unclear because Vangl2 protein levels significantly reduced or absent from tissues. Here we introduce knockout mouse directly compare severity phenotypes by...
Background: Programmed cell death, including apoptosis, mitochondria-mediated necrosis, and necroptosis, is critically involved in ischemic cardiac injury, pathological remodeling, heart failure progression. Whereas apoptosis necrosis signaling well established, the regulatory mechanisms of necroptosis its significance pathogenesis remain elusive. Methods: We examined role tumor factor receptor-associated 2 (Traf2) regulating myocardial remodeling using genetic mouse models. also performed...
Herein, we employed lead-free Cs3Cu2I5 perovskite films as the functional layers to construct Al/Cs3Cu2I5/ITO memory devices and systematically investigated impact on corresponding resistive switching (RS) performance via adding different amounts of hydroiodic acid (HI) in precursor solution. The results demonstrated that crystallinity morphology can be improved modulated by an appropriate amount HI. obtained 5 μL HI exhibit fewest lattice defects flattest surface (RMS = 13.3 nm). Besides,...
Mutations in TGF-β–activated kinase 1 binding protein 2 (TAB2) have been implicated the pathogenesis of dilated cardiomyopathy and/or congenital heart disease humans, but underlying mechanisms are currently unknown. Here, we identified an indispensable role for TAB2 regulating myocardial homeostasis and remodeling by suppressing receptor-interacting (RIPK1) activation RIPK1-dependent apoptosis necroptosis. Cardiomyocyte-specific deletion Tab2 mice triggered with massive apoptotic necroptotic...
Abstract Necroptosis has emerged as a new form of programmed cell death implicated in number pathological conditions such ischemic injury, neurodegenerative disease, and viral infection. Recent studies indicate that TGF β -activated kinase 1 (TAK1) is nodal regulator necroptotic death, although the underlying molecular regulatory mechanisms are not well defined. Here we reported TAK1 regulates signaling caspase 8-mediated apoptotic through both NF κ B-dependent -independent mechanisms....
The synthesis of 11 oligosaccharides (4-14) containing beta-arabinofuranosyl residues is reported. glycans are all fragments two polysaccharides, arabinogalactan and lipoarabinomannan, which found in the cell wall complex mycobacteria. In preparation targets, key step was a low-temperature glycosylation reaction that installed with good to excellent stereocontrol.
Impaired Ca2 + cycling and myocyte contractility are a hallmark of heart failure triggered by pathological stress such as hemodynamic overload. The A-Kinase anchoring protein AKAP150 has been shown to coordinate key aspects adrenergic regulation Ca2+ excitation–contraction in cardiomyocytes. However, the role signalling complexes pathogenesis not investigated. Here we examined how impact cycling, contractility, susceptibility following stress. We detected significant reduction expression...
Faithful progression through the cell cycle is crucial to maintenance and developmental potential of stem cells. Here, we demonstrate that neural cells (NSCs) intermediate progenitor (NPCs) employ a zinc-finger transcription factor specificity protein 2 (Sp2) as regulator in two temporally spatially distinct domains. Differential conditional deletion Sp2 early embryonic cerebral cortical progenitors, perinatal olfactory bulb progenitors disrupted transitions G1, G2 M phases, whereas DNA...
In recent years, the lead-free double perovskite Cs2AgBiBr6 has emerged as an appealing alternative to lead-based perovskites due its nontoxicity and long-term stability. this study, we employed methyl acetate antisolvent prepared high-quality films by a facile one-step spin-coating method. The exhibited excellent crystallinity with densely packed crystal grains. root mean square roughness average of obtained were 6.69 5.43 nm, respectively. Furthermore, memory device based on uniform...
Numerous findings demonstrate that there is a strong association between maternal health during pregnancy and cardiovascular disease in adult offspring. The purpose of the present study was to test whether gestational hypertension modulates brain renin-angiotensin-aldosterone system (RAAS) proinflammatory cytokines sensitizes angiotensin II-elicited hypertensive response In addition, role renal nerves RAAS sensitization process investigated. Reverse transcription polymerase chain reaction...
The collectivity of the electronic motion in graphene nanostructures is studied by time-dependent density functional theory (TDDFT). Compared with plasmon homogeneous graphene, nanostructure has some different properties due to effect size and all dimensional confinement. In lower-energy resonance zone, spectral band greatly broadening, even extending near-infrared area, photoabsorption strength line splits. absorption spectrum also depends on edge configuration nanostructure. armchair-edge...
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by the synovitis and bone erosion. The combination therapy of glucocorticoids (GCs) methotrexate (MTX) recommended in early RA management, although precise underlying mechanism action remains unclear. This study aimed to clarify MTX combined with GC treating RA.
Transverse aortic constriction (TAC) in mice has been used as a valuable model to study mechanisms of cardiac hypertrophy and heart failure1. A reliable noninvasive method is essential assess real-time morphological functional changes animal models disease. Transthoracic echocardiography represents an important tool for assessment structure function2. Here we high-resolution ultrasound imaging system monitor myocardial remodeling failure progression over time mouse TAC. B-mode, M-mode,...
Red mud is the solid waste residue of bauxite ore digestion with caustic soda for alumina (Al2O3) production. China currently biggest producer worldwide. However, comprehensive utilization rate red very low. Moreover, coal gangue also a complex industrial waste, which one largest in China. In this study, mud, gangue, fly ash, and other wastes were used to prepare road base material laboratory solve environmental issues caused by these wastes. The mechanical properties durability Bayer...
The physiologic actions of retinoic acids (RAs) are mediated through RA receptors (RARs) and retinoid X (RXRs). RAR α gene has drawn particular attention because it is the common target in all chromosomal translocations acute promyelocytic leukemia (APL), a unique model cancer research that responds to effect RA. In great majority patients with APL, fused PML as result t(15;17) translocation. Three distinct types PML-RAR transcripts, long (L), short (S), variant (V), were identified. V-type...
TAK1 (TGFβ-activated kinase-1) signaling is essential in regulating a number of important biological functions, including innate immunity, inflammatory response, cell growth and differentiation, myocardial homeostasis. The precise role the adult heart under pathological conditions remains largely unknown. Importantly, we observed that upregulated during compensatory hypertrophy but downregulated end-stage failure. Here generated transgenic mice with inducible expression an active mutant...