A5101864504- Renal Diseases and Glomerulopathies
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Diet and metabolism studies
- Hepatitis B Virus Studies
- Air Quality and Health Impacts
- Lipid metabolism and disorders
- Hepatitis C virus research
- Monoclonal and Polyclonal Antibodies Research
- Pregnancy and preeclampsia studies
- Genomics and Phylogenetic Studies
- Diet, Metabolism, and Disease
- Reproductive Biology and Fertility
- High Altitude and Hypoxia
- Celiac Disease Research and Management
- Methane Hydrates and Related Phenomena
- Gestational Diabetes Research and Management
- Cardiovascular and Diving-Related Complications
- Genomics and Rare Diseases
- Parasites and Host Interactions
- Pharmacological Effects of Natural Compounds
- Liver Diseases and Immunity
- Maternal and fetal healthcare
- Smoking Behavior and Cessation
- Obstructive Sleep Apnea Research
First Affiliated Hospital Zhejiang University
2024
Institute of Crop Sciences
2024
Chinese Academy of Agricultural Sciences
2024
Chongqing Medical University
2023
Second Affiliated Hospital of Nantong University
2021
Central South University
2021
Hangzhou Medical College
2021
Zhejiang Provincial People's Hospital
2021
Affiliated Hospital of Nantong University
2021
Nantong University
2021
Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage jaundice. In more cases, massive pulmonary haemorrhages, including fatal sudden haemoptysis, can occur1. Here we report the complete genomic sequence representative virulent serovar type strain (Lai)2 Leptospira interrogans serogroup Icterohaemorrhagiae consisting 4.33-megabase large chromosome 359-kilobase small chromosome, total...
Several studies have demonstrated that estrogen receptor α (ESR1) participates in the pathogenesis of persistent hepatitis B virus (HBV) infection. To examine whether polymorphisms at ESR1 gene locus are associated with HBV infection, we resequenced genomic region for single nucleotide (SNPs) 27 unrelated Chinese. Two haplotype-tagged SNPs (htSNP), T29C and A252966G, were selected genotyping 1,277 HBV-infected cases, 748 spontaneously recovered controls, 293 nuclear families using polymerase...
Abstract Introduction Glomerular microthrombosis (GMT) is a common vascular change in patients with lupus nephritis (LN). The mechanism underlying GMT largely unknown. Although several studies have reported the association of antiphospholipid antibodies (aPL) GMT, relation between and aPL remains controversial. Previous demonstrated that some could bind to hemostatic fibrinolytic proteases share homologous enzymatic domains. Of protease-reactive aPL, can inhibit anticoagulant activity...
Background . Lupus nephritis (LN) remains a major cause of morbidity and end-stage renal disease. Dysfunction B lymphocytes is thought to be important in the pathogenesis SLE/LN. Intrarenal cells have been found several forms inflammatory kidney diseases although their role LN not well defined. Methods were analyzed 192 biopsies from patients diagnosed with lupus nephritis. Immunohistochemical staining serial sections was performed for each patient using CD20, CD3, CD21 antibodies. Results...
Arabidopsis thaliana synthesizes various medicinal compounds, and serves as a model plant for research. Single-cell transcriptomics technologies are essential understanding the developmental trajectory of roots, facilitating analysis synthesis accumulation patterns compounds in different cell subpopulations. Although methods interpreting single-cell data rapidly advancing Arabidopsis, challenges remain precisely annotating identity due to lack marker genes certain types. In this work, we...
Introduction. Dysfunction of the B lymphocyte is considered to be involved in pathogenesis lupus nephritis (LN). Intrarenal cells have been found several forms inflammatory kidney disease. B-cell activating factor (BAFF) regulates proliferation and survival, contributes human autoimmune Their role renal inflammation not well defined. Methods. Clinical parameters biopsies from 62 LN patients were prospectively analyzed. We performed standard immunohistochemistry on serial paraffin tissue...
IgA nephropathy (IgAN) is a polygenic disorder. Increasing evidence has implicated that aberrant glycosylation of IgA1 molecules, including alpha2,6 sialic acid defects, are involved in the pathogenesis IgAN. In present study, we designed an association study to investigate polymorphisms two important genes, ST6GALNAC2 and NEU1, which sialylation molecule, susceptibility A total 670 patients with histologically proven IgAN 494 healthy controls were enrolled. Screening SNPs coding promoter...
Interleukin-13 (IL13) is believed to play an important role in the pathogenesis of atopy and allergic asthma. To better understand genetic variation at IL13 locus, we resequenced a 5.1-kb genomic region spanning entire locus identified 26 single-nucleotide polymorphisms (SNPs) 74 individuals from three major populations—Chinese, Caucasian, African. Our survey suggests exceptionally high significant geographic structure between African outside Africa populations. This unusual pattern that...
The NOTCH4 locus was reported to be associated with schizophrenia in our previous study but the subsequent replication by other workers has been inconsistent. To find out possible reasons for poor replication, present work undertaken analyse four functional single nucleotide polymorphisms (SNPs) (rs367398, rs915894, rs520692 and rs422951) at among 141 schizophrenic family trios of Chinese Han descent. Of these SNPs, only one (P = 0.017); three, however, did not show any association illness,...
Abstract Background The deficiency of β 1,3 galactose in hinge region IgA1 molecule played a pivotal role pathogenesis IgA nephropathy (IgAN). Cosmc, encoded by C1GALT1C1 gene, was indispensable to galactosylation IgA1. We designed serial study investigate the relationship between mutations gene and genetic susceptibility IgAN. Methods Nine hundred thirty-eight subjects, including 661 patients with IgAN 277 healthy controls were enrolled study. Firstly, single nucleotide polymorphisms (SNPs)...
To investigate the association of Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors and acute kidney injury in comparison to other classes drugs.A total 4966 diabetes mellitus patients were investigated for developing Acute Kidney Injury (AKI) who under prescription with following class drugs viz. SGLT2 Inhibitors, Dipeptidyl peptidase-4 (DDP4) inhibitors, Nonsteroidal anti-inflammatory (NSAIDs), first-line anti-biotics. The primary outcome was based on hospital encounter Disease Improving...
A large number of people around the world are exposed to risks passive smoking. This prospective study aimed examine association between secondhand smoke exposure, exposure time, and incidence chronic kidney disease (CKD) determine whether this was influenced by genetic susceptibility.The included 214244 participants UK Biobank who were initially free CKD. Cox proportional hazards model used estimate associations time CKD in have never smoked. The risk score for calculated a weighted method....