A5103095473- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Wnt/β-catenin signaling in development and cancer
- Protein Kinase Regulation and GTPase Signaling
- Thyroid Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- 14-3-3 protein interactions
- Genomics and Rare Diseases
- Peroxisome Proliferator-Activated Receptors
- RNA modifications and cancer
- Fatty Acid Research and Health
- Folate and B Vitamins Research
- RNA Research and Splicing
- Bipolar Disorder and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Birth, Development, and Health
- Cancer-related gene regulation
- Cholesterol and Lipid Metabolism
- Diet, Metabolism, and Disease
- DNA Repair Mechanisms
- Barrier Structure and Function Studies
- Mental Health Treatment and Access
- Tryptophan and brain disorders
Jilin University
2008-2018
Jilin Medical University
2010-2014
Center for Genomic Science
2014
China Agricultural University
2006-2011
National Natural Science Foundation of China
2004
Rural–urban differences in the prevalence of chronic diseases adult population northeast China are examined. The Jilin Provincial Chronic Disease Survey used personal interviews and physical measures to research presence a range among large sample rural urban provincial residents aged 18 79 years (N = 21 435). Logistic regression analyses were used. After adjusting for age gender, had higher hypertension, ischemic heart disease, cerebrovascular low back pain, arthritis,...
Objective The present study investigated the prevalence and risk factors for Metabolic syndrome. We evaluated association between single nucleotide polymorphisms (SNPs) in apolipoprotein APOA1/C3/A4/A5 gene cluster MetS analyzed interactions of environmental with MetS. Methods A on was conducted using data from a large cross-sectional survey representative population Jilin Province situated northeastern China. total 16,831 participations were randomly chosen by multistage stratified sampling...
Epigenetic changes may account for the doubled risk to develop schizophrenia in individuals exposed famine utero. We therefore investigated DNA methylation a unique sample of patients and healthy conceived during great China. Subsequently, we examined two case-control samples without exposure whole blood brain tissue. To shed light on causality relation between methylation, human fibroblasts nutritional deprivation. In famine-exposed patients, found significant hypermethylation dual...
Abstract The present study was designed to detect three single nucleotide polymorphisms (SNPs) located on 22q11 that thought as being of particularly importance for genetic research into schizophrenia. We recruited a total 176 Chinese family trios Han descent, consisting mothers, fathers and affected offspring with schizophrenia the analysis. transmission disequilibrium test (TDT) showed SNPs, rs10314 in 3′-untranslated region CLDN5 locus associated ( χ 2 = 4.75, P 0.029). other two...
Objective The purpose of this study was to explore the association between single nucleotide polymorphisms (SNPs) in phospholipase A2 (PLA2), group XIIA gene (PLA2G12A) and schizophrenia. Methods This included 1,063 schizophrenia patients 1,103 healthy controls from a Han Chinese Population Northeast China. Four tagSNPs (rs11728699 intron 1, synonymous rs2285714 exon 3, rs3087494 3' UTR, rs7694620 downstream region) PLA2G12A were selected, they genotyped by MALDI-TOF-MS technology....
Genetic variations represent major risk factors for Alzheimer's disease (AD). While familial early onset AD is associated with mutations in the amyloid precursor protein and presenilin genes, only e4 allele of apolipoprotein E (APOE) gene has so far been established as a genetic factor late sporadic AD. It suggested that C-->T (224Ala-->Val) transition within exon 2 cathepsin D (CTSD) might The objective this study was to investigate whether possession CTSD T increases developing AD,...
The present study aimed to investigate the prevalence and associated socio-demographic factors of passive smoking among women in Jilin Province, China.A cross-sectional was conducted 2012, using a self-reported questionnaire interview. A representative sample 9788 non-smoking aged 18-79 years collected Province China by multistage stratified random cluster sampling design. Descriptive data analysis 95% confidence intervals (CI) prevalence/frequency were conducted. Multivariable logistic...
Ghrelin, in humans, is a hormone secreted from the stomach with an orexigenic effect, which good for digestion and absorption, as well regulating physical growth, metabolism, energy balance. It also involved development of metabolic syndrome (MetS) type 2 diabetes mellitus (T2DM). This study assessed association between single nucleotide variants GHRL gene risk Han Chinese population.A case-control was performed on 3780 comprising 1813 MetS cases 1967 controls. Three missense polymorphisms...
Zinc finger protein 259 (ZNF259) binds to the cytoplasmic domain of epidermal growth factor receptor (EGFR) in quiescent cells and contributes tolipid metabolism. This case control study investigated association between ZNF259 single nucleotide polymorphisms (SNPs) metabolic syndrome (MetS).This included 1,812 MetS patients 2,036 controls from Jilin province Northeastern China. was diagnosed using International Diabetes Federation (IDF) criteria. Three SNPs (rs964184, rs2075290 rs2075294)...
This cross-sectional survey among Chinese university students aimed to estimate the prevalence and risk factors of major depressive disorder (MDD) undergraduates, in order provide basic information for prevention treatment depression college-aged population.A total 2,046 undergraduates were interviewed face using World Health Organization Composite International Diagnostic Interview Version 3.0 (WHO-CIDI, version 3.0). Statistical Manual Mental Disorders-IV (DSM-IV) criteria used diagnose...
The present study detected three single nucleotide polymorphisms (SNPs), BanISNP at the PLA2G4A locus, rs1648833 PLA2G4B and rs1549637 PLA2G4C to investigate a genetic association between cytosolic PLA2 (cPLA2) genes schizophrenia. A total of 240 Chinese parent-offspring trios Han descent were recruited for analysis. transmission disequilibrium test (TDT) showed allelic (chi(2) = 5.68, uncorrected P 0.017), but not rs1648833. conditioning on genotype (COG) revealed disease BanISNP-rs1648833...
Altered expression of six-transmembrane epithelial antigen prostate 4 (STEAP4) is linked to obesity, insulin insensitivity, metabolic homeostasis, and inflammation. This study assessed STEAP4 single nucleotide polymorphisms (SNPs) for association with a risk in developing syndrome Han Chinese population.A total 3375 subjects were included this case-control 1583 (MetS) patients 1792 healthy controls. Four SNPs (rs1981529, rs2040657, rs10263111, rs12386756) genotyped using polymerase chain...
Diagnosis of schizophrenia does not have a clear objective test at present, so we aimed to identify the potential biomarkers for diagnosis by comparison serum protein profiling between first-episode patients and healthy controls. The combination magnetic bead separation system with matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry (MALDI-TOF/TOF-MS) was used analyze spectra 286 schizophrenia, 41 chronic disease 304 FlexAnlysis 3.0 ClinProTools(TM) 2.1...
Ataxia telangiectasia mutated (ATM) gene is critical in the process of recognizing and repairing DNA lesions related to invasion metastasis malignancy. The incidence rate papillary thyroid cancer (PTC) has increased for several decades higher females than males. In this study, we want investigate whether ATM polymorphisms are associated with gender-specific PTC. 358 PTC patients Northern China, including 109 males 249 females, were included our study. Four single nucleotide (SNPs) genotyped...
The incidence rate of papillary thyroid cancer (PTC) has increased over the past decades, but pathogenesis remains unclear. rs2910164, located in pre-miR-146a, been studied PTCs with different ethnicity, results were inconsistent. Here we evaluate association between rs2910164 polymorphism and PTC investigate effect this on patients’ clinicopathological characteristics. 1238 patients 1275 controls, all Han population, from Northern China, included our study. was genotyped using...