A5100386585- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Inflammatory Bowel Disease
- MicroRNA in disease regulation
- Microbial Inactivation Methods
- Cancer, Hypoxia, and Metabolism
- Genetic factors in colorectal cancer
- Quantum Mechanics and Non-Hermitian Physics
- Lung Cancer Research Studies
- Listeria monocytogenes in Food Safety
- Metamaterials and Metasurfaces Applications
- Quantum chaos and dynamical systems
- Breast Lesions and Carcinomas
- Machine Learning in Bioinformatics
- Plant Gene Expression Analysis
- Frailty in Older Adults
- Artificial Intelligence in Healthcare
- Inflammasome and immune disorders
- Botanical Studies and Applications
- Plant Ecology and Taxonomy Studies
- Cancer Treatment and Pharmacology
- Marine Biology and Environmental Chemistry
Shandong University
2022-2025
Shandong First Medical University
2022-2025
Shandong Tumor Hospital
2022-2025
Fuyang City People's Hospital
2023
Jiangsu Academy of Agricultural Sciences
2022-2023
Jiangsu University
2022-2023
First Affiliated Hospital of Henan University of Traditional Chinese Medicine
2023
Zoucheng People's Hospital
2021-2023
Henan Provincial People's Hospital
2023
Zhengzhou University
2023
To evaluate the efficacy and safety of aumolertinib in treating non-small cell lung cancer (NSCLC) patients with leptomeningeal metastasis (LM) epidermal growth factor receptor (EGFR) mutations. We conducted a retrospective analysis clinical data from 79 EGFR-mutated advanced NSCLC treated after being diagnosed LM at Shandong Cancer Hospital Institute between April 2020 July 2023. evaluated overall survival (OS), progression-free (PFS), LM-PFS, safety. Patient prognosis was assessed using...
This study aims to investigate the functional role of long non-coding RNA XIST in epithelial ovarian cancer (EOC).Detection expression levels EOC tissues and cell lines was done using qRT-PCR. The relationship between clinicopathological features patients compared analyzed. cumulative survival rates were calculated Kaplan-Meier. A Cox hazard model used identify risk factors for survival. Lastly, effects on assessed vitro.XIST up-regulated lines. closely related tumor grade, distant...
Abstract Backgrounds Elderly and frailty individuals show a more senescent immune system, which may relate to worse outcome in community‐acquired pneumonia (CAP). This study aimed explore prognostic factors related immune. Methods Sixty of elderly (≥65 years) (clinical scale ≥5 scores) nonsevere CAP patients 60 severe (SCAP) were recruited at our center. Clinical laboratory data, several assessment scores collected. Results Compared with group, the SCAP showed higher level BMI, PaCO2 lactate...
The incidence rate of papillary thyroid cancer (PTC) has increased over the past decades, but pathogenesis remains unclear. rs2910164, located in pre-miR-146a, been studied PTCs with different ethnicity, results were inconsistent. Here we evaluate association between rs2910164 polymorphism and PTC investigate effect this on patients’ clinicopathological characteristics. 1238 patients 1275 controls, all Han population, from Northern China, included our study. was genotyped using...
The pursuit of artificial structures exhibiting unusual acoustic properties is a major scientific endeavor, in which anti-parity-time (PT) symmetry has been coming into view recent years. At the same time, with emergence new metamaterials, classical Fabry–Perot resonance mode also exhibits fascinating scattering features similar to those anti-PT-symmetric system. We derive generalized relation for parameters an system transfer matrix, including conjugate bidirectional reflection coefficients...
Impurities usually affect the transmission of acoustic signals, and how to effectively suppress their adverse effects is an important content in research materials. In a recent theoretical proposal, it was pointed out that perfect through impurities can be achieved by adding gain-loss distribution respecting parity-time ($\mathcal{PT}$) symmetry. this paper, we demonstrate similar but not identical way realize extraordinary physical property impurity-shielding, which leads at so-called...
Objectives. To verify whether the concentrations and integrity index of circulating cell-free DNA (cfDNA) in serum may be clinically useful for progression monitoring colorectal cancer (CRC) patients. Methods. Serum samples were collected from 76 primary CRC patients who underwent surgery, including 60 with chemotherapy 43 follow-up. Long (247 bp) short (115 fragments detected by real-time quantitative PCR amplifying ALU repeats. Ten traditional biomarkers levels chemiluminescence...
Expression levels of transmembrane protein 41A (TMEM41A) are related to the progression malignant tumors. However, association between TMEM41A expression and endometrial carcinoma (EC) remains unclear. This study aims identify roles in prognosis patients with EC its correlation progression. The survival were assessed. Cox regression analysis was used prognostic factors, while nomograms examine factors EC. Finally, link level immune microenvironment RNA modifications investigated...
We compared intestinal microbes in anterior noninfectious scleritis patients with and without rheumatoid arthritis. Active other immune diseases (G group, 16 patients) or active arthritis (GY seven were included this study. Eight age- sex-matched healthy subjects served as controls (N group). DNA was extracted from fecal samples. The V3-V4 16S rDNA region amplified sequenced by high-throughput analysis, microbial contents determined. A significant decrease species richness the GY group...
In the present work, Listeria monocytogenes was used as target strain to investigate sterilising potential and mechanism of high power pulse microwave (HPPM). Results showed that inactivation positively correlated with frequencies operating times. The count decreased by 5.09 log CFU/mL under 200 Hz for 9 min, which optimised condition further explore sterilisation mechanism. Scanning electron microscopy (SEM) transmission (TEM) images L. cells untreated group presented intact surfaces, clear...
Aim: Increasing studies have demonstrated lymph node ratio (LNR) to be an accurate prognostic indicator in breast cancer and alternative pN staging; however, the AJCC-TNM staging system classified apical or infraclavicular/ipsilateral supraclavicular node-positive (APN(+)) patients with a worse prognosis as pN3 stage. Until now, different reports on LNR ignored this possibility. Consequently, it is necessary discuss role of APN(+) obtain precise that predicts accurately. Materials Methods:...
Abstract Background : LOC105371267 (also known as PR-lncRNA1) was reported to be a p53-regulated lncRNA, which played essential roles in the pathogenesis of breast cancer (BC). We aimed investigate potential associations between polymorphisms and BC risk. Method Totally, 555 healthy individuals 561 patients were recruited. Five candidate SNPs genotyped with Agena MassARRAY system. Odds ratio (OR) 95% confidence intervals (CIs) applied evaluate relationship susceptibility. Additionally,...
Leptomeningeal metastasis (LM) occurs in 3~5% of non-small cell lung cancer (NSCLC) patients. Diagnosis patients with LM and disease monitoring remains challenging due to the low sensitivity specificity commonly used approaches, such as cerebrospinal fluid (CSF) cytology magnetic resonance imaging (MRI). Therefore, new approaches are necessary improve detection LM. Recent studies have shown that circulating tumor DNA (ctDNA) CSF can be detect monitor LM, but whether it serve an early...
Objective To Investigate the concentration of VILIP-1 and NR2 peptide in serum patients with ischemic stroke,and to explore their clinic value early diagnostic stroke patients. Methods The levels were examined by ELISA (enzyme linked immunosorbent assay,ELISA) suspicious TIA (defined as a neurological deficit that resolved within 24 hours) or acute (within 72 hours onset symptoms) 340 cases,102 healthy controls,98 vascular risk factors 35 hemorrhagic stroke.Among all groups,VILIP-1...
Abstract Background Ulcerative colitis (UC) is an inflammatory bowel disease that leads to UC-associated colorectal cancer (UC-CRC), causing high mortality. Understanding UC-CRC's molecular mechanisms vital for early diagnosis and treatment. The sensitivity specificity of traditional tumor markers such as CEA, CA199, CA153 are poor, establishing the need more sensitive detection markers. Here we describe clinical application miR-21 miR-223 combined with CLDN8 new UC-CRC biomarkers. Methods...