A5101519903- RNA Research and Splicing
- Ion Transport and Channel Regulation
- Microtubule and mitosis dynamics
- Nuclear Structure and Function
- Wnt/β-catenin signaling in development and cancer
- Ubiquitin and proteasome pathways
- Ion channel regulation and function
- Plant Virus Research Studies
- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
- Cancer Risks and Factors
- Bone Metabolism and Diseases
- Breast Cancer Treatment Studies
- Signaling Pathways in Disease
- Cardiovascular Function and Risk Factors
- Cancer-related molecular mechanisms research
- Cardiomyopathy and Myosin Studies
- Breast Lesions and Carcinomas
- Neuroblastoma Research and Treatments
- Genetic Associations and Epidemiology
- Plant-Microbe Interactions and Immunity
- Genomics and Chromatin Dynamics
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cellular transport and secretion
- Chemical Reactions and Isotopes
South China Normal University
2021-2024
Peking University First Hospital
2016-2024
Peking University
2016-2024
Zhengzhou Central Hospital
2024
Tianjin Medical University Cancer Institute and Hospital
2019-2023
Tianjin Medical University
2023
North China University of Water Resources and Electric Power
2023
Nanchang University
2018
Second Affiliated Hospital of Nanchang University
2018
Abstract Background Metastasis of breast cancer grows from the local invasion to distant colonization. Blocking step would be promising for treatment. Our present study demonstrated AQP1 was a crucial target in invasion. Methods Mass spectrometry combined with bioinformatics analysis used identify associated proteins ANXA2 and Rab1b. Co-immunoprecipitation, immunofluorescence assays cell functional experiments were carried out define relationship among AQP1, Rab1b their re-localization...
Abstract Anthracyclines are a class of conventional and commonly used frontline chemotherapy drugs to treat breast cancer. However, the anthracycline-based regimens can only reduce cancer mortality by 20–30%. Furthermore, there is no appropriate biomarker for predicting responses this kind currently. Here we report our findings that may fill gap showing AQP1 (Aquaporin1) protein as potential response predictor in anthracycline chemotherapy. We showed patients with high level expression who...
Intersectin1 (ITSN1) contains two isoforms: ITSN1-S and ITSN1-L, which is highly regulated by alternative splicing. However, the alteration of splicing its importance in cancer still unknown. In this study, our transcriptome analysis using a large glioma cohort indicated isoforms exerted opposite function progression. Our previous results had shown could promote development; however, ITSN1-L remained we first confirmed that an inhibitory role progression both vivo vitro, was contrary to...
Most pathogenic
Geminiviruses are an important group of viruses that infect a variety plants and result in heavy agricultural losses worldwide. The homologs C4 (or L4) monopartite geminiviruses AC4 AL4) bipartite critical viral proteins. proteins from several the substrates S-acylation, dynamic post-translational modification, for maintenance their membrane localization function virus infection. Here we initiated screening identified plant protein ABAPT3 (Alpha/Beta Hydrolase Domain-containing Protein...
Abstract Protein S-acylation is an important post-translational modification in eukaryotes, regulating the subcellular localization, trafficking, stability, and activity of substrate proteins. The dynamic regulation this reversible mediated inversely by protein S-acyltransferases de-S-acylation enzymes, but mechanism remains unclear plant cells. Here, we characterized a group putative enzymes Arabidopsis thaliana, including 11 members Alpha/Beta Hydrolase Domain-containing 17-like acyl...
Objective Observational studies have reported that mental disorders are comorbid with temporomandibular joint disorder (TMD). However, the causal relationship remains uncertain. To clarify between three common illnesses and TMD, we conduct this Mendelian Randomization (MR) study. Methods The large-scale genome-wide association data of major depression, bipolar schizophrenia were retrieved from Psychiatric Genomics Consortium. summary TMD was obtained Finn-Gen consortium, including 211,023...
Anterior gradient 3 (AGR3) belongs to human anterior (AGR) family. The function of AGR3 on cancer remains unknown. This research aimed investigate if had prognostic values in invasive ductal carcinoma (IDC) breast and could promote tumor progression.AGR3 expression was detected benign lesions, situ IDC by immunohistochemistry analysis. AGR3's correlations with clinicopathological features prognosis patients were analyzed. By cell experiments, collagen gel droplet-embedded culture drug...
Abstract Intersectin 1 (ITSN1) contains two isoforms: ITSN1-S and ITSN1-L, which are highly regulated by alternative splicing. Our previous results showed that the isoforms of ITSN1 displayed opposite functions: promoted glioma development, while ITSN1-L exerted an inhibitory role in progression. In this study, our transcriptome analysis using a large cohort indicated ratio ITSN1-S/ITSN1-L was positively correlated with grading poor prognosis. We identified RNA-binding protein polypyrimidine...
Aim: Increasing studies have demonstrated lymph node ratio (LNR) to be an accurate prognostic indicator in breast cancer and alternative pN staging; however, the AJCC-TNM staging system classified apical or infraclavicular/ipsilateral supraclavicular node-positive (APN(+)) patients with a worse prognosis as pN3 stage. Until now, different reports on LNR ignored this possibility. Consequently, it is necessary discuss role of APN(+) obtain precise that predicts accurately. Materials Methods:...
Abstract OBJECTIVE To analyze the myocardial involvement and explore strain characteristics of left atrium ventricle in patients with Fabry disease (FD) using conventional echocardiography 2-dimensional speckle tracking (2D-STE). METHODS A retrospective study was conducted. Sixty-nine FD who were treated Department Cardiology, Neurology Nephrology Peking University First Hospital from August 2014 to February 2023 underwent examination Cardiology collected (FD group). During same time, 69...
Abstract Breast cancer is the most common type of worldwide. However, well-known molecular biomarkers are not enough to meet needs precision medicine. In search for novel targets in this regard, we reported ITSN1 (intersectin1) as one candidates through mRNA microarray analysis. present study, that endocytic protein ITSN1-S exists only cytoplasm but also nuclei breast cells. ITSN1-S′ functional nuclear localization signal within its residues 306–312. Its export (NES) resides SH3 domains. We...