A5086428234- Effects and risks of endocrine disrupting chemicals
- Remote Sensing and Land Use
- Regional Economic and Spatial Analysis
- RNA Research and Splicing
- Fungal and yeast genetics research
- Adipose Tissue and Metabolism
- Air Quality and Health Impacts
- Biofuel production and bioconversion
- Toxic Organic Pollutants Impact
- Liver Disease Diagnosis and Treatment
- Birth, Development, and Health
- Traditional Chinese Medicine Studies
- Microplastics and Plastic Pollution
- Plant Virus Research Studies
- Metabolomics and Mass Spectrometry Studies
- Chinese history and philosophy
- Natural product bioactivities and synthesis
- Evaluation Methods in Various Fields
- Renin-Angiotensin System Studies
- Environmental and Agricultural Sciences
- Per- and polyfluoroalkyl substances research
- China's Socioeconomic Reforms and Governance
- Healthcare and Venom Research
- Research, Science, and Academia
- Apelin-related biomedical research
South China Normal University
2009-2024
Jinan University
2010-2024
Sichuan University
2024
West China Second University Hospital of Sichuan University
2024
Second Institute of Oceanography
2024
Ministry of Natural Resources
2024
Center for Excellence in Brain Science and Intelligence Technology
2023
University of Chinese Academy of Sciences
2023
Liaoning University
2023
China Medical University
2023
The substituted p-phenylenediamines (PPDs) represent a suite of effective antioxidants broadly applied in rubber industries. However, knowledge their environmental occurrences and fate remains extremely limited. Herein, we explored the occurrence six major PPD one newly defined transformation product dust particles from different environments, including roads, underground parking lots, vehicles, houses. majority PPDs exhibited ubiquitous these environments. Median concentrations total were...
Elucidating the cellular organization of cerebral cortex is critical for understanding brain structure and function. Using large-scale single-nucleus RNA sequencing spatial transcriptomic analysis 143 macaque cortical regions, we obtained a comprehensive atlas 264 transcriptome-defined cell types mapped their distribution across entire cortex. We characterized layer region preferences glutamatergic, GABAergic, non-neuronal types, as well regional differences in cell-type composition...
Tissue kallikrein is a serine protease thought to be involved in the generation of bioactive peptide kinins many organs like kidneys, colon, salivary glands, pancreas, and blood vessels. Low renal synthesis urinary excretion tissue have been repeatedly linked hypertension animals humans, but exact role cardiovascular function has not established largely because lack specific inhibitors. This study demonstrates that mice lacking are unable generate significant levels most tissues develop...
Diabetic nephropathy is a major risk factor for end-stage renal disease and cardiovascular diseases has marked genetic component. A common variant (D allele) of the angiotensin Iconverting enzyme ( ACE ) gene, determining higher levels, been associated with diabetic nephropathy. To address causality underlying this association, we induced diabetes in mice having one, two, or three copies normal blood pressure, an level range (65–162% wild type) comparable to that seen humans. Twelve weeks...
N-(1,3-Dimethyl butyl)-N′-phenyl-phenylenediamine-quinone (6PPD-Q) is a derivative of the widely used rubber tire antioxidant 6PPD, which was first found to be acutely toxic coho salmon. Subsequent studies showed that 6PPD-Q had species-specific acute toxicity in fishes and potential hepatotoxicity mice. In addition, has been reported human urine, demonstrating widespread exposure humans this chemical. However, whether poses higher risk than its parent compound, could cause adverse effects...
Characterization of gestational exposure to complex contaminants emerging concern (CECs) is critical the identification environmental risk factors for pregnancy complications. However, determination various CECs with diverse physicochemical properties in biological fluids technically challenging. In present study, we developed a target exposome protocol, consisting simple liquid-liquid extraction-based sample preparation and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
RNA capping and decapping tightly coordinate with transcription, translation, decay to regulate gene expression. Proteins in the DXO/Rai1 family have been implicated mRNA decay, mammalian DXO was recently found also function as a enzyme for NAD+ -capped RNAs (NAD-RNA). The Arabidopsis genome contains single encoding protein, AtDXO1. Here we show that AtDXO1 possesses both NAD-RNA activity 5'-3' exonuclease but does not hydrolyze m7 G cap. atdxo1 mutation increased stability of NAD-RNAs led...
Abstract —Spontaneous rupture of the internal elastic lamina (IEL) occurs in some arteries rat during growth and aging. Inbred, normotensive, Brown Norway (BN) rats are particularly susceptible to IEL, especially abdominal aorta (AA). Preliminary experiments showed that different angiotensin-converting enzyme (ACE) inhibitors protect against IEL BN a greater extent than hydralazine, suggesting role renin-angiotensin system (RAS) this phenomenon. To explore possibility, we have treated male...
Objective This research aimed to elucidate the relationship between testosterone levels and serum soluble klotho (S-klotho) concentrations in females aged 40-79 years using National Health Nutrition Examination Survey (NHANES) dataset. Design Associations S-klotho were assessed through multivariable linear regression methodologies, spanning nonadjusted, minimally adjusted, fully adjusted models. Settings The investigation was conducted as a cross-sectional analysis utilizing NHANES database....
Discogobio brachyphysallidos Huang Citation1989 is a Cyprinidae fish species that endemic to the upper Pearl River. In present study, complete mitochondrial genome of D. collected from Nanpanjiang River was sequenced and annotated. The encompassed 13 protein-coding genes, two ribosomal RNA (rRNA) 22 transfer (tRNA) control region (D-loop). total length determined be 16,594 base pairs (bp), with GC content 41.7%. Phylogenetic analyses revealed may sister longibarbatus macrophysallidos. These...
Niga-ichigoside F1 ameliorated high-fat diet-induced hepatic steatosis by increasing Nrf2 nuclear translocation to regulate lipid metabolism genes expression in livers of C57BL/6J mice.
Myricetin attenuated hepatic steatosis by regulating miR-146b to target TRb and subsequent T3 responsive genes involved in lipid metabolism.
Increasing studies have utilized mass spectrometry imaging (MSI) that is a label-free tool to investigate drug penetration and biotransformation in multicellular tumor spheroids (MCTS). Currently, the gelatin-assisted sectioning method widely used prepare frozen sections of MCTS for MSI. However, owing limited transparency gelatin, with diameters less than 500 μm closely mimic solid tumors are difficult be detected when cryosectioning. In order identify presence MCTS, hematoxylin eosin...