Abstract Background Solute carrier family 7 member 11(SLC7A11) is a component of cysteine/glutamate transporter, which plays key role in tumor growth; however, its underlying effect on radiosensitivity esophageal squamous cell carcinoma (ESCC) remains unclear. This study aimed to clarify SLC7A11’s expression and correlation with nuclear factor erythroid-2 ( NRF2)-associated radioresistance ESCC. Methods We included 127 ESCC patients who received radical chemoradiotherapy. Immunohistochemical...

Abstract Background The antiviral drug Nirmatrelvir was found to be a key in controlling the progression of pneumonia during infectious phase COVID-19. However, there are very few options for effective treatment cancer patients who have viral pneumonia. Glucocorticoids is one means control pneumonia, but many adverse events. EGCG natural low toxic compound with anti-inflammatory function. Thus, this study designed investigate safety and efficacy epigallocatechin-3-gallate (EGCG) aerosol...

Migrasomes are recently discovered vesicle-like structures on retraction fibers of migrating cells that have been linked with transfer cellular contents, shedding unwanted materials, and information integration. However, whether how the cell migration paradigm regulates migrasome formation is not clear. Here, we report there significantly fewer migrasomes in turning compared straight persistently cells. The major insight underlying this observation as elongate, their rear ends become...

Abstract Background Chemoresistance is one of the major obstacles for cancer therapy in clinic. Circular RNAs (circRNAs) are involved pathogenesis esophageal squamous cell carcinoma (ESCC) and chemoresistance. This study aimed to explore role molecular mechanism circ_0006168 Taxol resistance ESCC. Methods The expression levels circ_0006168, microRNA-194-5p (miR-194-5p) jumonji domain containing 1C (JMJD1C) were measured by quantitative real-time polymerase chain reaction (qRT-PCR) or western...

:BackgroundAs one of the cancers with highest incidence and mortality rates worldwide, timeliness accuracy cell type diagnosis in lung cancer are crucial for patients' treatment decisions. This study aims to develop a novel deep learning model provide efficient, accurate, cost-effective auxiliary pathological types cells.MethodThis paper introduces named PortNet, designed significantly reduce model's parameter size achieve lightweight characteristics without compromising classification...

Esophageal cancer, with its aggressive nature and high mortality, poses diverse epidemiological challenges worldwide. Over the past three decades, esophageal cancer has exhibited a substantial global burden, marked by significant increase in absolute numbers, contrasting decline age-standardized metrics. Prevalence nearly doubled, reaching 0.961 million 2019, while rate (ASR) decreased to 11.6 per 100,000 cases. New incidence cases surged 67.07%, yet reduced 6.5 Deaths increased 0.498...

To evaluate the efficacy and safety of aumolertinib in treating non-small cell lung cancer (NSCLC) patients with leptomeningeal metastasis (LM) epidermal growth factor receptor (EGFR) mutations. We conducted a retrospective analysis clinical data from 79 EGFR-mutated advanced NSCLC treated after being diagnosed LM at Shandong Cancer Hospital Institute between April 2020 July 2023. evaluated overall survival (OS), progression-free (PFS), LM-PFS, safety. Patient prognosis was assessed using...

Osimertinib combined with chest radiotherapy has a high incidence of pneumonia, dacomitinib is widely used in clinical practice, but there are no studies reporting the pulmonary safety combinating radiotherapy. Here we report case radiation pneumonitis occurring by and thoracic (TRT). The patient was 55-year-old woman lung adenocarcinoma. She had received surgery adjuvant chemotherapy. presented bilateral intramammary para-aortic metastatic lymphadenopathy, which confirmed as metastasis,...

There is a significant unmet need in treating patients with limited-stage small-cell lung cancer (LS-SCLC). The ETER701 study showed that Benmelstobart (TQB2450, an anti-PD-L1 antibody) combined Anlotinib and chemotherapy achieved the longest progression-free survival (PFS) overall (OS) as first-line therapy extensive-stage small cell (ES-SCLC). This suggests TQB2450 represent promising treatment combination for LS-SCLC. prospective aimed to evaluate efficacy safety of maintenance LS-SCLC...

Abstract Blockade of the T cell immunoreceptor with immunoglobulin and tyrosine-based inhibitory motif domain (TIGIT) can enhance innate adaptive tumor immunity radiotherapy (RT) anti-tumor immunity. However, our data suggest that TIGIT-mediated immune suppression may be an impediment to such goals. Herein, we report on synergistic effects RT combined anti-TIGIT therapy mechanism their interaction. Treatment efficacy was assessed by measuring primary secondary growth, survival, memory...

CD155/TIGIT overexpression has been detected in various human malignancies; however, its expression status primary small cell carcinoma of the esophagus (PSCCE) and prognostic significance remain unclear. In this study, we aimed to explore value CD155 TIGIT PSCCE. We 114 cases PSCCE using immunohistochemistry (IHC) evaluated their relationship with clinicopathological characteristics survival patients. Survival analyses were performed Kaplan-Meier method Cox proportional hazards model....

Growing numbers of clinical trials test the efficacy radiotherapy (RT) plus immune checkpoint inhibitors (ICIs), but number irradiated sites is not uniform. We aimed to evaluate single-site RT immunotherapy in oligometastatic non-small cell lung cancer (NSCLC) with smaller disease burdens and low tumor heterogeneity. retrospectively identified NSCLC (< 4 metastatic sites) patients treated PD-1 pathway or without a single lesion our institution between 2018 2020. The primary endpoints were...

This study aimed to determine the prognostic value of sarcopenia on progression free survival (PFS) and overall (OS) esophageal squamous cell cancer (ESCC) patients who received radiotherapy (RT) or chemoradiotherapy (CRT).Data clinicopathological characteristics nutritional parameters were analyzed correlated with PFS OS, retrospectively. Skeletal muscle, subcutaneous, visceral total fat tissue cross-sectional areas evaluated CT images at midpoint 3rd lumbar vertebrae. A 213 enrolled in...

The geriatric nutritional risk index (GNRI) has been shown to be associated with the prognosis of cancer patients except for hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE). Our aim is examine association between GNRI and long-term in HCC who underwent TACE. Patients TACE were enrolled. relationship patient characteristics compared, independent prognostic factors investigated. Nomogram performance was assessed via concordance (C-index) calibration plots. Decision...

TCF1+CD8+T cells are reported to exhibit stem-like properties with the ability self-renew and differentiate into terminal effector T (TCF1-CD8+T cells) enhance antitumor response. Previous studies indicated that TCF1+CD8+ tumor-infiltrating lymphocytes (TILs) related response immunotherapy. However, their role in predicting prognosis for patients primary small cell carcinoma of esophagus (PSCCE) remains unclear. In this study, expression was analyzed by multiplex fluorescence...

Abstract Introduction There is no standard treatment for locoregional recurrent (LR) esophageal squamous cell carcinoma (ESCC) patients treated with radiotherapy (RT) previously. This retrospective study aimed to examine the efficacy and toxicity of re-irradiation (re-RT) ESCC LR. Patients methods A total 252 were enrolled. Gross tumor volumes re-RT defined using contrast enhanced computed tomography and/or positron emission tomography/computed tomography. Overall survival (OS), after...

Abstract Background The safety of thoracic radiotherapy (TRT) after programmed death 1/programmed ligand 1 (PD‐(L)1) inhibitor treatment in patients with lung cancer was scarcely reported. This retrospective study conducted to evaluate the incidence, severity, and risk factors symptomatic treatment‐related pneumonitis who received this sequential combination. Methods We a cohort TRT at least two cycles PD‐(L)1 between January 2018 August 2020. Treatment‐related evaluated analyzed illustrate...

Results from Lung ART and PORT-C trials suggest that postoperative radiotherapy (PORT) cannot routinely be recommended as standard treatment in completely resected pIIIA-N2 NSCLC patients, but their effects on the real-world practice of PORT China remain unclear.A national cross-section survey was conducted by using an online service. Participants were voluntarily recruited a river sampling strategy. A link to posted websites radiation oncologist associations tweets public WeChat accounts....

To explore the value of parameters multiphase dynamic contrast-enhanced magnetic resonance imaging (MDCE-MRI) in qualitative diagnosis hepatic masses. Eighty patients with masses were retrospectively analyzed. All underwent MDCE-MRI at 3.0 T MR before treatment. Mean enhancement time (MET), positive integral (PEI), a maximum slope increase (MSI), and decrease (MSD) measured. There significant differences between benign malignant respect to MET, PEI, MSI values. The PEI values hemangiomas,...

Background Immune checkpoint inhibitors (ICIs) have been clinically proven to be efficient in non-small cell lung cancer (NSCLC). However, it has also found that immunotherapy is not effective for all patients. For instance, some patients with epidermal growth factor receptor (EGFR) mutation tumors a low overall response rate ICIs. As result, we retrospectively analyzed the efficacy of anti-programmed death-ligand 1 (anti-PD-L1) blockade (atezolizumab) treatment patient EGFR mutation, and...

Abstract Purpose: Growing numbers of clinical trials test the efficacy radiotherapy (RT) plus immune checkpoint inhibitors (ICIs), but number irradiated sites is not uniform. We aim to evaluate single-site RT immunotherapy in oligometastatic non-small cell lung cancer (NSCLC) with smaller disease burdens and low tumor heterogeneity. Methods: retrospectively identified NSCLC (≤4 metastatic sites) patients treated PD-1 pathway or without a single lesion our institution between 2018 2020. The...

Background: Esophageal cancer, characterized by its aggressive nature and high mortality, poses diverse epidemiological challenges worldwide. This study aims to provide a comprehensive understanding of global burden, accounting for variations in prevalence, incidence, deaths, Disability-Adjusted Life Years (DALYs). It seeks address the need an in-depth analysis that integrates various metrics across different regions, thereby informing effective health strategies policies. Methods: Utilizing...