A5100457368- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Cancer Cells and Metastasis
- Cardiac Ischemia and Reperfusion
- Intensive Care Unit Cognitive Disorders
- Pain Mechanisms and Treatments
- Cancer Treatment and Pharmacology
- Burn Injury Management and Outcomes
- Cancer Risks and Factors
- Herpesvirus Infections and Treatments
- Hedgehog Signaling Pathway Studies
- Vascular Malformations Diagnosis and Treatment
- Alkaloids: synthesis and pharmacology
- Ion Channels and Receptors
- Organ Transplantation Techniques and Outcomes
- Tumors and Oncological Cases
- Vascular Malformations and Hemangiomas
- Medicinal Plants and Bioactive Compounds
- Nuclear Receptors and Signaling
China-Japan Friendship Hospital
2015-2025
Xinxiang Medical University
2024
Guangzhou Medical University
2023-2024
Guangzhou First People's Hospital
2023-2024
Shandong First Medical University
2024
Jilin Agricultural University
2024
Shandong Provincial Hospital
2024
Shanghai Jiao Tong University
2018-2023
Fourth Hospital of Hebei Medical University
2023
Guilin Medical University
2023
Hydrogen sulfide (H2S) is the third most common endogenously produced gaseous signaling molecule, but its impact on hepatic ischemia/reperfusion (I/R) injury, especially mitochondrial function, remains unclear. In this study, rats were randomized into Sham, I/R, ischemia preconditioning (IPC) or sodium hydrosulfide (NaHS, an H2S donor) groups. To establish a model of segmental (70%) warm ischemia, artery, left portal vein and median liver lobes occluded for 60 min then unclamped to allow...
Long noncoding RNAs (lncRNAs) are involved in various human diseases. Recently, H19 was reported to be upregulated fibrotic rat lung and play a stimulative role bleomycin (BLM)-induced pulmonary fibrosis mice. However, its expression tissues mechanism of action remain unclear. Here, our observations showed that significantly microRNA 140 (miR-140) markedly reduced from idiopathic (IPF) patients transforming growth factor β1 (TGF-β1)-induced HBE A549 cells. Moreover, the negatively correlated...
Accumulating evidence suggests that circular RNAs (circRNAs) play important roles in various physiological and pathological processes. In the present study, we explored role of circRNA PVT1 hepatocellular carcinoma (HCC). qRT-PCR was performed to detect relative expression circPVT1 HCC tissues cell lines. The oncogenic were evaluated by counting kit-8 (CCK-8) assay, ethynyl deoxyuridine (EdU) incorporation assays, transwell flow cytometry vivo xenograft growth. Furthermore, bioinformatics,...
Circular ribonucleic acids (circRNAs) are a type of RNA that originates through back-splicing events from linear primary transcripts. CircRNAs display high structural resistance and tissue specificity. Accurate quantification the circRNA expression level is vital importance to disease diagnosis. Herein, we construct label-free fluorescent biosensor for ultrasensitive analysis circRNAs based on integration target-initiated cascade signal amplification strategy with light-up G-quadruplex. This...
The unique expression pattern endows oncofetal genes with great value in cancer diagnosis and treatment. However, only a few are available for clinical use the underlying mechanisms that drives fetal-like reprogramming of cells remain largely unknown.Microarray assays bioinformatic analyses were employed to screen potential long non-coding RNAs (lncRNAs) hepatocellular carcinoma (HCC). levels MIR4435-2HG, NOP58 ribonucleoprotein (NOP58), insulin like growth factor 2 mRNA binding protein 1...
Clinically, chronic pain and depression often coexist in multiple diseases reciprocally reinforce each other, which greatly escalates the difficulty of treatment. The neural circuit mechanism underlying pain/depression comorbidity remains unclear. present study reports that two distinct subregions paraventricular thalamus (PVT) play different roles this pathological process. In first subregion PVT posterior (PVP), glutamatergic neurons (PVP
Exosomes assume a pivotal role as essential mediators of intercellular communication within tumor microenvironments. Within this context, long noncoding RNAs (LncRNAs) have been observed to be preferentially sorted into exosomes, thus exerting regulatory control over the initiation and progression cancer through diverse mechanisms.
The objective of this study was to estimate cancer burden attributable excess body weight (EBW) and identify its main source. We obtained relative risks from meta-analyses, population data the Global Burden Disease Study (GBD) 2021, BMI prevalence NCD Risk Factor Collaboration (NCD-RisC). calculated incidence 11 cancers high 1990 analyzed trends using joinpoint regression, assessed cohort effects with age-period-cohort model. Decomposition analysis conducted by cancer-specific risk factors...
ABSTRACT Preconditioning with volatile anesthetics, such as isoflurane and sevoflurane, can protect the myocardium against ischemia/reperfusion injury (IRI). Syntaxin1A (Stx1A) is cardioprotective regulated by anesthetics. However, mechanism which sevoflurane preconditioning (SPC) induces Stx1A to exert myocardial protection remains unclear. The study investigates whether SPC upregulation of through thymoma viral proto‐oncogene (AKT)/Glycogen synthase kinase 3 β (GSK3β) signaling pathway....
The ubiquitous Gram-negative bacterial pathogen Aeromonas veronii (A. veronii) can easily cause inflammatory reactions in aquatic organisms, resulting high mortality and huge economic losses. MicroRNAs (miRNAs) participate immune regulation have certain conserved properties. MiRNAs are involved the responses of a variety teleost fish infected with bacteria, whereas there is no related report silver carp (Hypophthalmichthys molitrix). Therefore, we identified expression profiles miRNA...
Summary Aims The intravenous anesthetic propofol caused episodic memory impairments in human. We hypothesized episodic‐like spatial retention but not acquisition rats and rescuing c AMP response element‐binding protein ( CREB ) signaling using selective type IV phosphodiesterase (PDEIV) inhibitor rolipram reversed these effects. Methods Male S prague‐ D awley were randomized into four groups: control; (25 mg/kg, intraperitoneal); rolipram; + (pretreatment of 25 min before propofol, 0.3...
The aim of the present study was to explore signaling pathway noscapine which induces apoptosis by blocking liver-intestine cadherin (CDH17) gene in colon cancer SW480 cells.Human cells were transfected with CDH17 interference vector and treatment 10 µmol/L noscapine. proliferation detected MTT assay AnnexinV-FITC/PI flow cytometry kit (BD), respectively. Cell invasion assessed transwell assays. Apoptosis related proteins (Cyt-c, Bax, Bcl-2 Bcl-xL) levels evaluated western blot.Compared...
Background. Malignant pleural effusion (MPE) is a common complication in most malignancies. Despite its frequent occurrence, current knowledge of MPE remains limited and the effect management still unsatisfying. Traditional Chinese medicine (TCM) external treatment has unique advantages, such as quicker efficacy fewer side effects. Objective. To observe effects safety Kang’ai Xiaoshui ointment (TCM herbal ointment) MPE. Design. This was placebo-controlled double-blinded randomized study. A...
Circular RNA (circRNA) is a key regulator of tumor progression. However, the role circFOXM1 in glioblastoma (GBM) progression unclear. The aim this study was to investigate GBM expression levels circFOXM1, miR-577, and E2F transcription factor 5 (E2F5) were examined by real-time quantitative polymerase chain reaction. Cell counting kit 8 assay, EdU staining, transwell assay used detect cell proliferation, migration, invasion. glutamine, glutamate, α-ketoglutarate determined evaluate...
Despite longstanding efforts to develop cytoprotective drugs against ischemia/reperfusion (IR) injuries, there remains no effective therapeutics treat hypoxic injury. The failure of traditional strategies at solving this problem suggests the need for novel and unbiased approaches that can lead previously unsuspected targets compounds. Towards end, we report here a unique small molecule screen in nematode C. elegans compounds improve recovery when applied after insult, using strain engineered...
PM2.5 can cause adverse health effects via several pathways, such as inducing pulmonary and systemic inflammation, penetration into circulation, activation of the autonomic nervous system. In particular, impact exposure on liver, which plays an important role in metabolism detoxification to maintain internal environment homeostasis, is getting more attention recent years. present study, C57BL/6J mice were randomly assigned treated with suspension PBS solution for 8 weeks. Then, hepatic...
It has been reported that circFAT1 plays opposite roles in gastric cancer and osteosarcoma. This study aimed to explore the involvement of colorectal (CRC).Paired CRC non-tumor tissues from 64 patients were subjected RNA preparations RT-qPCRs determine expression circFAT1, premature miR-10a, mature miR-10a. In cells, effects overexpression on miR-10a maturation analyzed by determining both using RT-qPCRs. The role regulating proliferation, invasion, migration cells was BrdU Transwell assays,...