A5100410147- Mesenchymal stem cell research
- Bone Tissue Engineering Materials
- Salivary Gland Tumors Diagnosis and Treatment
- Craniofacial Disorders and Treatments
- Cleft Lip and Palate Research
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- Dental Implant Techniques and Outcomes
- Head and Neck Cancer Studies
- Cancer-related gene regulation
- Periodontal Regeneration and Treatments
- Immune cells in cancer
- TGF-β signaling in diseases
- Bone Metabolism and Diseases
- Oral and Maxillofacial Pathology
- Cancer, Hypoxia, and Metabolism
- Tissue Engineering and Regenerative Medicine
- Angiogenesis and VEGF in Cancer
- Virus-based gene therapy research
- Vascular Malformations and Hemangiomas
- RNA Research and Splicing
- Peptidase Inhibition and Analysis
- Bone Tumor Diagnosis and Treatments
- Cancer-related Molecular Pathways
- Oral Health Pathology and Treatment
Peking University Third Hospital
2024
Peking University
1999-2024
First Affiliated Hospital of Guangzhou Medical University
2024
Guangzhou Medical University
2024
Shandong University
2011-2022
Qilu Hospital of Shandong University
2009-2021
University of California, Los Angeles
2019
Stomatology Hospital
2014-2018
Liaocheng People's Hospital
2016
Central South University
2013
Objective The present study aimed to explore the clinical significance of neutrophils infiltration and carcinoembryonic antigen related cell adhesion molecule 1 (CEACAM1) expression in tongue squamous carcinoma (TSCC), probe possible relationship between them. Materials Methods Tissue microarray immunohistochemistry were used detect density CEACAM1 74 cases primary TSCC specimens 17 corresponding peritumoral tissues. with clinicopathologic parameters cancer-related survival patients...
Inadequate vascularization limits the repair of bone defects. In order to improve angiogenesis and accelerate osteogenesis, synergism co-cultured cells with genetic modification in regeneration was investigated this study. Endothelial progenitor (EPCs) marrow stem (BMSCs) were transfected genes vascular endothelial growth factor (VEGF) morphogenetic protein 2 (BMP2) by adenovirus, respectively. The cells, designated as four groups including BMSC + EPC, Ad-BMP2-BMSC Ad-VEGF-EPC, Ad-VEGF-EPC...
DNA methyltransferases (DNMTs) 1, 3a, and 3b affect promoter methylation; studies have suggested that they important roles in the development of cancers. In this study, we analyzed expression DNMTs 3b; MIB-1 labeling index; their clinical significance 6 normal retinas 62 retinoblastomas using immunohistochemical analysis. We found DNMT proteins were not expressed retinas, whereas frequently (DNMT1, 100%; DNMT3a, 98%; DNMT3b, 92%). Compared with well-differentiated retinoblastomas, 1 3a...
Previous studies have demonstrated that the overexpression of Kif2a is involved in progression, invasion and metastasis squamous cell carcinoma oral tongue (SCCOT). Few reported correlation between apoptosis tumor cells which signaling pathways remains unclear. The phosphatidylinositol‑3‑kinase (PI3K)/protein kinase B (Akt) pathway frequently activated many types human cancer. aim present study was to investigate effects downregulation Kif2 expression on P13K/Akt Tca8113 determine whether...
Oral squamous cell carcinoma (OSCC) accounts for >80% of head and neck malignancies. p21, p27 survivin proteins are abnormally expressed in OSCC have been previously reported to correlate with proliferation apoptosis. However, the prognostic significance remains controversial. The aim present study was investigate association clinical parameters prognosis levels expression patients OSCC. three biomarkers were evaluated by immunohistochemical staining specimens from 110 each section scored...
17alpha-Hydroxylase deficiency is a rare form of congenital adrenal hyperplasia caused by CYP17 gene mutations.Five Chinese patients with 17alpha-hydroxylase were genotyped.The five derived from four families living in Shandong Province, China. The diagnosis was initially established through HPLC serum profiles Qilu Hospital, China, 1983-1993.Three mutations identified these patients. Among them, V311fs and Y329fs are two novel frame-shifting mutations. an 8-bp nucleotide (TTAAATGG) deletion...
Crosstalk between tumor infiltrating macrophages and cells is thought to play an indispensable role in oral squamous cell carcinomas (OSCC) by induction maintenance of tolerance microenvironment. High infiltration M2 increasing expression Kinesin family member 4A (Kif4A) primary OSCC have been proved correlate with greater tumoral size poor clinical outcome. However, linkage Kif4A tumorigenesis progression remains unclear. In the present study, we show that, interaction THP-1derived...
In this study, docetaxel (DTX) was successfully conjugated to the monomethoxy-poly(ethylene glycol)-<italic>b</italic>-poly(lactide) (mPEG-PLA) polymer block <italic>via</italic> an ester linkage (DTX-PM).
Carcinoembryonic antigen cell adhesion molecule 1 ( CEACAM 1), a transmembrane glycoprotein, has multiple functions. In tongue squamous carcinoma TSCC ), overexpression is correlated with neutrophil infiltration, and both are associated poor clinical outcomes. However, the mechanism underlying 1's effect on function in remains unclear. We cocultured cells overexpressing 1‐4L, 1‐4S differentiated HL ‐60 cells. This significantly upregulated expression of MMP ‐9, interleukin 8, VEGF ‐A...
Abstract Background To evaluate the prognostic value of preoperative neutrophil lymphocyte ratio (NLR) and platelet (PLR) in oral, pharyngeal, lip cancer for survival relapse. Methods Clinic‐pathologic hematological records were retrospectively retrieved. Patients completed follow‐up period included relapse analysis. Results The NLR was a factor both overall relapse‐free survival. high group demonstrated higher total rate, local rate within 12 months. However, PLR did not associate with or...
The precise mechanism of how TNF‐α promotes osteoclast formation is not clear. Previous reports show targets molecules that regulate calcium signaling. Inositol‐1,4,5‐trisphosphate receptors (IP3Rs) are important channel responsible for evoking intracellular oscillation. We found increased the expression IP3R1 and promoted osteoclastogenesis in RANKL‐induced mouse BMMs. Phosphatidylcholine‐specific phospholipase C (PC‐PLC) specific inhibitor D609 eliminated upregulation by TNF‐α, decreased...