A5100442359- Aluminum toxicity and tolerance in plants and animals
- Microbial Metabolic Engineering and Bioproduction
- Nanoparticle-Based Drug Delivery
- Wnt/β-catenin signaling in development and cancer
- Enzyme Catalysis and Immobilization
- RNA Interference and Gene Delivery
- Antifungal resistance and susceptibility
- Bacterial biofilms and quorum sensing
- Enzyme Structure and Function
- Trace Elements in Health
- Nanoplatforms for cancer theranostics
- Anesthesia and Sedative Agents
- Fungal Infections and Studies
- Alzheimer's disease research and treatments
- Pharmacological Effects and Assays
- Metabolomics and Mass Spectrometry Studies
- Veterinary Pharmacology and Anesthesia
- Analytical Chemistry and Chromatography
- Biofuel production and bioconversion
- Antibiotics Pharmacokinetics and Efficacy
- Curcumin's Biomedical Applications
- Genetic Associations and Epidemiology
- Mycotoxins in Agriculture and Food
- Protein Structure and Dynamics
- Biochemical Analysis and Sensing Techniques
Deyang Stomatological Hospital
2023-2025
Shandong University
2014-2025
Shell (United States)
2023
Energy Biosciences Institute
2023
University of Illinois Urbana-Champaign
2023
Jiangsu Agri-animal Husbandry Vocational College
2022
Shandong Provincial Hospital
2015-2020
Shandong First Medical University
2020
Shuguang Hospital
2018
Guangxi Medical University
2018
Carboxylic acids are an attractive biorenewable chemical. However, like many other fermentatively produced compounds, they inhibitory to the biocatalyst. An understanding of mechanism toxicity can aid in mitigating this problem. Here, we show that hexanoic and octanoic completely Escherichia coli MG1655 minimal medium at a concentration 40 mM, while decanoic acid was 20 mM. This growth inhibition is pH-dependent accompanied by significant change fluorescence polarization (fluidity)...
Osteoarthritis (OA) is a chronic condition characterized by pain during joint movement. Additionally, patients with advanced disease experience at rest (ie, ongoing pain) that generally resistant to nonsteroidal antiinflammatory drugs. Injection of monosodium iodoacetate (MIA) into the intraarticular space rodent knee well-established model OA elicits weight-bearing asymmetry and referred tactile thermal hypersensitivity. Whether present in this unknown. possible relationship MIA dose not...
Monitoring brassinosteroids (BRs) has been of major interest researchers as these substances play a crucial role in variety phytological processes plants. However, the determination endogenous BRs plant tissue is still challenging task due to their low abundance and complex matrix tissues. In this study, single step strategy by combining tip extraction situ derivatization was proposed for BR analysis. strategy, mixed mode sorbent (C8-SO3H) modified with 4-phenylaminomethyl-benzeneboric acid...
The present study was performed to investigate the therapeutic performance of polymer‐lipid hybrid nanoparticles towards delivery lapatinib ( LPT ) in breast cancers. We have successfully developed lapatinib‐loaded nanosystem and showed its potential vitro vivo models cancer. nanoformulations consisted a polymeric core (poly[lactide‐co‐glycolide]‐ D ‐a‐tocopheryl polyethylene glycol 1000 succinate [ PLGA – TPGS ]), which then enveloped by PEG ylated lipid layer DSPE ‐ PLPT maintain...
Occupational heat-related illness (OHI) is a health threat to workers that can be fatal in severe cases. Effective and feasible measures are urgently needed prevent OHI. We evaluated the effectiveness of multifaceted intervention, TEMP, reducing OHI risk among outdoor power grid industry. A cluster randomized controlled trial was conducted with Southern China from 4 July 2022 28 August 2022. Work groups were randomly allocated (1:1) intervention or control groups. The TEMP comprised mobile...
Objectives SERINC2 has been associated with alcoholism, bipolar disorder and autism, but the comparability specificity issues of findings remain unaddressed. The present study aimed to comprehensively analyze various neuropsychiatric disorders pinpoint most reliable conditions predisposed by . Methods A total 2,187 imputed SNPs across were examined in 1,167,439 subjects from 72 independent cohorts 18 different disorders. SNP-disease associations tested then meta-analyzed, followed FDR...
Combination therapy can be used for the treatment of fungal infections, especially those caused by antifungal-resistant fungi. In present study, in vitro interactions and mechanisms between fluconazole minocycline against Candida albicans were evaluated. The nature determined spectrophotometric method a checkerboard assay was interpreted using nonparametric models fractional inhibitory concentration index (FICI) percentages growth difference (ΔE). mechanism we evaluated potential activity on...
Veterinary drugs are widely used in animal husbandry to prevent and treat diseases, promote growth, improve the conversion rate of feed. However, use veterinary food-producing animals may leave residues parent compounds, and/or their metabolites food products resulting harmful effects humans. To ensure safety, sensitive effective analytical methods have been developing rapidly. So it is necessary make a systematic summary detection drug residues. Sample preparation techniques two main parts...
Candida albicans is a clinically important fungus and capable of forming biofilms, which contributes to the emergence fluconazole resistance. Here, sessile minimum inhibitory concentrations (SMICs) combined with doxycycline against biofilms C. were determined, results SMICs compared (MICs) planktonic cells. MICs determined by microdilution checkerboard method, interactions between two drugs interpreted models fractional concentration index percentage growth difference (△E). For formed over...
A SIL–LC–DNLS–MS strategy for profiling of aldehyde-containing compounds is presented.
Carboxylic acids are an attractive biorenewable chemical. Enormous progress has been made in engineering microbes for production of these compounds though titers remain lower than desired. Here we used transcriptome analysis Escherichia coli during exogenous challenge with octanoic acid (C8) at pH 7.0 to probe mechanisms toxicity. This highlights the intracellular acidification and membrane damage caused by C8 challenge. Network component identified transcription factors altered activity...
Polycyclic aromatic hydrocarbons (PAHs) are one species of persistent organic pollutants (POPs) with strong carcinogenicity and teratogenicity. They can be widely found in the environment, which cause great harm to ecological environment. In addition, they endanger human health by polluting food from natural environment processing. Therefore, it is necessary accurately detect PAHs various sample matrices, requires accurate, practical rapid detection methods. This review aims investigate...
It is difficult to manage coinfections in critically ill patients, especially the presence of mixed-species biofilms. The aim this study was seek an effective drug combination for managing dual-species biofilm Candida albicans and Staphylococcus aureus.The interaction between fluconazole minocycline against polymicrobial planktonic cells biofilms formed over four different time intervals (4 hours, 8 12 24 hours) investigated using a microdilution checkerboard method. To explore whether...
Elaioplasts of citrus peel are colorless plastids which accumulate significant amounts terpenes. However, other functions elaioplasts have not been fully characterized to date. Here, a LC-MS/MS shotgun technology was applied identify the proteins from that were highly purified young fruit kumquat. A total 655 putative plastid identified according sequence homology in silico and manual curation. Based on functional classification via Mapman, ~50% fall into six categories, including protein...