A5106407335- Gene Regulatory Network Analysis
- Microbial Metabolic Engineering and Bioproduction
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Genetic Mapping and Diversity in Plants and Animals
- Organ Transplantation Techniques and Outcomes
- Biochemical and Structural Characterization
- Origins and Evolution of Life
- Genetics, Bioinformatics, and Biomedical Research
- Liver Disease and Transplantation
- Wastewater Treatment and Nitrogen Removal
- Plant Disease Resistance and Genetics
- Potato Plant Research
- GABA and Rice Research
- Endoplasmic Reticulum Stress and Disease
- Evolution and Genetic Dynamics
- Computational Drug Discovery Methods
- Biofuel production and bioconversion
- Mycotoxins in Agriculture and Food
- Circular RNAs in diseases
- Bacterial Genetics and Biotechnology
- Cancer Genomics and Diagnostics
- Algal biology and biofuel production
- Fungal and yeast genetics research
- CRISPR and Genetic Engineering
Gansu University of Traditional Chinese Medicine
2024
Harbin Medical University
2024
First Affiliated Hospital of Harbin Medical University
2024
University of Auckland
2024
Wayne State University
2020
Sichuan Agricultural University
2016-2018
Rice Research Institute
2016
University of New Haven
2015
Yale University
2015
Iowa State University
2011-2014
Although the roles of metabolic stress in organ ischemia-reperfusion injury (IRI) have been well recognized, question whether and how these responses regulate innate immune activation against IR remains unclear. In a murine liver partial warm ischemia mode, we showed that prolonged triggered endoplasmic reticulum (ER) response, particularly, activating transcription factor 6 (ATF6) branch, Kupffer cells (KCs) altered their responsiveness Toll-like receptor (TLR) stimulation. Ischemia-primed...
Abstract Background Gene regulatory networks play essential roles in living organisms to control growth, keep internal metabolism running and respond external environmental changes. Understanding the connections activity levels of regulators is important for research gene networks. While relevance score based algorithms that reconstruct from transcriptome data can infer genome-wide networks, they are unfortunately prone false positive results. Transcription factor activities (TFAs)...
Carboxylic acids are an attractive biorenewable chemical. Enormous progress has been made in engineering microbes for production of these compounds though titers remain lower than desired. Here we used transcriptome analysis Escherichia coli during exogenous challenge with octanoic acid (C8) at pH 7.0 to probe mechanisms toxicity. This highlights the intracellular acidification and membrane damage caused by C8 challenge. Network component identified transcription factors altered activity...
Rice is one of the most important staple crops. It has been major focus in breeding program to improve grain yield. A unique feature tetraploid rice increased size and weight compared diploid. Therefore, investigating effects genome doubling on expression genes regulating for yield improvement program. In this study, we analyzed differential six young panicles various developmental stages between diploid rice. Transgenic approaches were employed explore dosage gene size. The results showed...
The central dogma of molecular biology can be conceptualised as the division labour between templates and catalysts, where transmit genetic information, catalysts accelerate chemical reactions, information flows from to but not templates. How template-catalyst evolve in primordial replicating systems? A previous study has shown that even if does provide an immediate fitness benefit, it through symmetry breaking molecules when are compartmentalised into protocells. However, cellular...
Ischemia–reperfusion injury (IRI) is a cumulation of pathophysiological processes that involves cell and organelle damage upon blood flow constraint subsequent restoration. However, studies on overall immune infiltration ferroptosis in liver ischemia-reperfusion (LIRI) are limited. This study explored LIRI using bioinformatics experimental validation. The GSE151648 dataset, including 40 matched pairs pre- post- transplant samples was downloaded for bioinformatic analysis. Eleven hub genes...
Abstract Mutations in key regulatory sequences have been suggested to cause oncogenesis. However, identification of noncoding cancer “drivers” from thousands somatic alterations is a difficult and unsolved problem. We report computational framework, FunSeq, annotate prioritize these mutations. The framework combines an adjustable data context integrating large-scale genomics (e.g. ENCODE) resources with streamlined variant-prioritization pipeline. pipeline has weighted scoring system...
Grain filling is an extremely important process in rice growth and development. This which involves complex genetic regulatory networks environmental interaction, directly related to the formation of yield quality. A stable inherited mutant with grain extended ( gef1 ) was identified from EMS mutagenized population Yixiang 1B. The investigation agronomic traits, measurement physiological biochemical characteristics, histology observation, gene expression analysis mapping were performed this...
Abstract BackgroundWe have identified an environmentally inducible gene, mdig that predicted the overall survival in breast cancer patients. We showed regulated cell growth, motility and invasion partially through DNA histone methylation. However, we lacked a comprehensive analysis of proteomic profile triple negative cells. MethodsWe applied mass spectrometry to acquire global post translational modification for cells MDA-MB-231 had deleted via CRISPR Cas 9 gene editing. Using label-free...