A5051400288- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Magnetism in coordination complexes
- Lanthanide and Transition Metal Complexes
- Advanced Chemical Physics Studies
- Advanced NMR Techniques and Applications
- Molecular Sensors and Ion Detection
- Inorganic Fluorides and Related Compounds
- Advanced biosensing and bioanalysis techniques
- Physics of Superconductivity and Magnetism
- Metal-Organic Frameworks: Synthesis and Applications
- Cancer-related molecular mechanisms research
- Inorganic Chemistry and Materials
- RNA modifications and cancer
- Organic and Molecular Conductors Research
- Electrochemical sensors and biosensors
- Crystallography and molecular interactions
- Ferroptosis and cancer prognosis
- Advanced Condensed Matter Physics
- Synthesis and Biological Evaluation
- Metal-Catalyzed Oxygenation Mechanisms
- Electron Spin Resonance Studies
- MicroRNA in disease regulation
- Synthesis of heterocyclic compounds
- Luminescence and Fluorescent Materials
Ministry of Education of the People's Republic of China
2016-2025
Northwest University
2016-2025
Harbin Medical University
2020-2025
First Affiliated Hospital of Harbin Medical University
2020-2025
Anhui University
2020-2023
Chinese Academy of Sciences
1990-2023
University of Science and Technology of China
2023
China XD Group (China)
2014-2021
Hefei University
2020
Science North
2018
Three new rhodamine-based probes Y1-Y3 were synthesized as "off-on" chemosensors for Fe(3+) imaging in living cells. The recognizing behaviors investigated both experimentally and computationally. crystal structure of the complex Y3-Fe(3+) revealed that preferred to coordinate with N atom benzothiazole moiety rather than O carboxyl group.
A broad-spectrum fluorescent probe, which can be applied to monitoring H2S in various biological systems, has been rationally designed and synthesized. This specific probe was localize the endogenous living Raw264.7 macrophage cells, HepG2 H9C2 cells. At same time, successfully visualized CBS- CSE-induced production monitored CBS CSE activity could serve as a powerful molecular imaging tool further explore physiological function mechanisms of animal systems.
A method to predict the relaxation time of quantum tunneling magnetization and magnetic reversal barrier with efficiency reliability.
Abstract Background The endoplasmic reticulum (ER) regulates critical processes, including lipid synthesis, which are affected by transmembrane proteins localized in the ER membrane. One such protein, protein 147 (TMEM147), has recently been implicated for its role hepatocellular carcinoma (HCC) tumorigenesis; however, mechanisms remain unclear. We investigated of TMEM147 HCC and underlying mechanisms. Methods expression was examined human cells adjacent non-tumorous tissues using...
Hepatic ischemia‒reperfusion injury (HIRI) is a common pathological phenomenon after hepatectomy and liver transplantation. Here, we aim to explore the role of Axin formation inhibitor 1 (Axin1) in HIRI. In this work, find that expression Axin1 upregulated Cellular experiments confirme knockdown alleviated hypoxia/reoxygenation (H/R)-induced inflammation apoptosis. Subsequently, construct HIRI model based on transgenic hepatocellular-specific knockout overexpression male mice deletion...
A theoretical study, based on ab initio electronic structure calculation, is performed in a group of 16 pentacoordinate Dy-SIMs. Theoretical results provide reasonable explanation the observed SMM performance concise criterion, i.e., co-existence long τQTM and high Ueff. To have desired favoring good performance, contribution from equatorial coordinating atoms might be even more important than that axial atoms. Widening ∠O–Dy–O probable way to improve pentacoordinated Starting existing...
We previously observed that the HERV type K (HERV-K) envelope (env) protein was expressed in majority of human breast tumors from a U.S. cohort women Texas. also made preliminary observation expression HERV-K env transcripts associated with markers disease progression. In this follow-up study, evaluated immunohistochemically an additional 195 paraffin-embedded second patient (Baltimore, Maryland) and 110 Chinese patients. Moreover, we compared transcript between fresh-frozen normal cancerous...
An efficient strategy for the synthesis of various 1,4,5,6-tetrahydropyrimidine and 2-imidazoline derivatives has been reported. The reactions proceeded from nitriles with ethylenediamine or 1,3-diaminopropane via cascade cycloaddition in presence CuL<sub>2</sub> (L = 2-hydroxy-2-phenylacetate) to afford corresponding under reflux conditions microwave irradiation excellent yields.
Two chromium(<sc>ii</sc>) complexes exhibit single-molecule-magnet behavior due to uniaxial magnetic anisotropy revealed by and HF-EPR studies.
In this work, a large excess of electrostatic repulsion, arising from the axial ligands, over that equatorial ligands is taken as design strategy for high performance pentagonal bipyramidal (PBP) Dy<sup>III</sup> single-ion magnets (SIMs).
Abstract A hybrid coumarin–thiazole compound was developed as a novel ratiometric and colorimetric sensor for bisulfite anions. Structure identification of the confirmed by 1 H NMR, 13 C H, COSY, heteronuclear single quantum coherence (HSQC), IR, HRMS spectroscopy. The detection anions performed through Michael addition anion toward sensor. reaction between caused fluorescence intensity to decrease at 600 nm increase 450 simultaneously yielded visible color change from purplish red colorless...
The generation of two types complexes with different topological connections and completely structural merely via the substitution effect is extremely rare, especially for -CH3 -C2H5 substituents similar physical chemical properties. Herein, we used 3-methoxysalicylaldehyde, 1,2-cyclohexanediamine, Dy(NO3)3·6H2O to react under solvothermal conditions (CH3OH:CH3CN = 1:1) at 80 °C obtain butterfly-shaped tetranuclear DyIII cluster [Dy4(L1)4(μ3-O)2(NO3)2] (Dy4, H2L1...
Metal nanoclusters are excellent electrochemiluminescent luminophores owing to their rich electrochemical and optical properties. However, the activity of electrochemiluminescence (ECL) is unknown. Herein, we achieved, for first time, integration ECL,
Intrahepatic cholangiocarcinoma (ICC) is a highly malignant and aggressive cancer whose incidence mortality continue to increase, whereas its prognosis remains dismal. Tumor-associated macrophages (TAMs) promote progression immune microenvironment remodeling through direct contact secreted mediators. Targeting TAMs has emerged as promising strategy for ICC treatment. Here, we revealed the potential regulatory function of responsive gene 1 (IRG1) in macrophage polarization. We found that IRG1...
Abstract Taking advantage of the steric hindrance and charge‐driving effects, four air‐stable pentagonal bipyramidal mononuclear Dy III compounds were hydrothermally synthesized. With a tetradentate ligand, N , ′‐bis(2‐methylenepyridinyl)ethylenediamine (Bpen), invariably coordinates to in an equatorial plan, 1 – 3 achieve orderly transformation ligand field by sequentially replacing remaining sites ion. Compound 4 possesses same coordination atoms but different peripheral sphere with ....
Two mononuclear trigonal-planar Co(<sc>ii</sc>) complexes with a similar coordination environment except for the symmetries were reported to exhibit distinct relaxation dynamics due effect of QTM and direct process.
The design and synthesis of simple lanthanide complexes with multiple functions have been widely studied faced certain challenges. Herein, we successfully synthesized the series binuclear [Ln2(L1)2(NO3)4] (HL1 = 2-amino-1,2-bis(pyridin-2-yl)ethanol; Ln Dy (Dy2), Tb (Tb2), Ho (Ho2) Er (Er2)) via in situ self-condensation Ln(NO3)3·6H2O-catalyzed 2-aminomethylpyridine (16 steps) under solvothermal conditions. Dy2 was mixed different volatile organic solvents, photoluminescence tests...
Two DyIII complexes, [Dy(bbpen-F)X] [X = Cl (1), Br (2); H2bbpen-F N,N'-bis(2-hydroxybenzyl)-N,N'-bis(5-fluoro-2-methylpyridyl)ethylenediamine], have been synthesized that show remarkable single-molecule-magnet behavior with effective barriers of magnetic reversal 837.7 K for 1 and 1149.7 2 under zero direct-current field hysteresis loops up to 20 30 2, as confirmed by properties ab initio calculations.
A theoretical method, taking into account the anisotropy of internal magnetic field (<italic>B⃑</italic><sub>int</sub>), is proposed to predict rate quantum tunneling magnetization (QTM), <italic>i.e.</italic>, <italic>τ</italic><sub>QTM</sub><sup>−1</sup>, for Kramers single-ion magnets (SIMs).