A5083200062- Molecular Sensors and Ion Detection
- Sulfur Compounds in Biology
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Chemical Synthesis and Analysis
- Luminescence and Fluorescent Materials
- Advanced Nanomaterials in Catalysis
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Multicomponent Synthesis of Heterocycles
- Analytical Chemistry and Sensors
- Telomeres, Telomerase, and Senescence
- Photochromic and Fluorescence Chemistry
- Photoreceptor and optogenetics research
- Nitric Oxide and Endothelin Effects
- Sulfur-Based Synthesis Techniques
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Chemical Synthesis and Reactions
- Synthesis and Biological Evaluation
- Oxidative Organic Chemistry Reactions
- Electrochemical Analysis and Applications
- Photochemistry and Electron Transfer Studies
- Cyclopropane Reaction Mechanisms
- Circadian rhythm and melatonin
- Asymmetric Hydrogenation and Catalysis
Northwest University
2015-2025
Northwest A&F University
2025
Ministry of Education of the People's Republic of China
2014-2024
China XD Group (China)
2019-2020
First Hospital of Shanxi Medical University
2017
Shanxi Medical University
2017
Jilin University
2014
Institut de Chimie Organique et Analytique
2014
Université d'Orléans
2013-2014
Air Force Medical University
2008-2011
Spirocyclization of xanthene dyes has become a powerful technique for developing fluorescent probes. Herein, we extend this unique fluorescence switching mechanism to near-infrared (NIR) dye, 2-(7-diethylamino-2-oxo-2H-1-benzopyran-3-yl)-4-(2-carboxyphenyl)-7-diethylamino-1-benzopyrylium (CB), and construct ratiometric probe 1 cysteine (Cys)/homocysteine (Hcy). The sensing toward Cys/Hcy is realized by utilizing tandem native chemical ligation/spirocyclization reaction interrupt the large...
Hypochlorous acid (HOCl), a reactive oxygen species (ROS), plays crucial role in the process of pathogenic oxidative stress. Some powerful anticancer agents, such as elesclomol, specifically induce cancer cell apoptosis by increasing HOCl levels. However, sensitive tools to monitor subtle changes biological vivo are limited. To achieve this, we herein present rationally designed probes C1-C7 through introducing bioorthogonal dimethylthiocarbamate receptor. All were shown sensitively and...
Abstract The tracking of cellular senescence usually depends on the detection senescence‐associated β‐galactosidase (SA‐β‐gal). Previous probes for SA‐β‐gal with this purpose only cover a single dimension: accumulation enzyme in lysosomes. However, is insufficient to determine destiny because endogenous β‐gal enriched lysosomes not related senescence, but also some other physiological processes. To address issue, we introduce our fluorescent including second lysosomal pH, since...
A novel coumarin-based fluorogenic probe bearing the tris unit (DAT-1) with high selectivity and suitable affinity toward Fe3+ over other cations tested was developed in biological systems. The sensing mechanism studied by quantum calculations. can be applied to monitoring of aqueous solution a pH span 3–8. In addition, imaging, membrane permeability nontoxicity demonstrate that DAT-1 could act as turn-off fluorescent chemosensor for living cells.
Hypochlorous (HOCl) acid is generated as a defense tool in the immune system and plays vital role killing wide range of pathogens. There therefore great interest developing fluorescent probes that can endogenously respond to change concentration HOCl vivo. To address this challenge, we here present rapidly responding probe RO610 image endogenous living mice. The development was based on novel water-soluble pH-independent xanthene dye, 2'-formylrhodol ROA, which exhibits highly selective...
Abstract A hybrid coumarin–thiazole compound was developed as a novel ratiometric and colorimetric sensor for bisulfite anions. Structure identification of the confirmed by 1 H NMR, 13 C H, COSY, heteronuclear single quantum coherence (HSQC), IR, HRMS spectroscopy. The detection anions performed through Michael addition anion toward sensor. reaction between caused fluorescence intensity to decrease at 600 nm increase 450 simultaneously yielded visible color change from purplish red colorless...
The first-generation chemical probes for species-selective fluorescence imaging of human senescence-associated β-galactosidase are developed.
Delayed wound healing is one of the major diabetes complications that occur in 25% diabetic patients. Specific management and combination treatment are required to repair wound, which still remains a challenge with few effective therapies available currently. In this work, new H2S donor PRO-F, characterized by capability promote diabetes, was designed. PRO-F can be activated light without consuming endogenous substances accompanying fluorescent signal makes real-time tracking released...
Abstract Coumarins and its analogues have been widely used as chromophore in design of fluorescent probe, while less coumarin‐based probe was reported for detection anion water. In this article, probes with salicylaldehyde functionality recognition unit developed selective bisulfite anions Four novel were synthesized from 4‐haloresorcinol three steps. The chemoprobe exhibited response to over other anions. Moreover, the mechanism studied. Upon added, intensity enhanced highly due...
Here, we report a senescence-associated β-galactosidase activatable theragnostic prodrug to pertinently treat chronic renal failure (CRF) in mice with the aid of fluorescence-guided senolysis, providing creative molecular approach CRF therapy.
Abstract The pursuit of pharmacological interventions in aging aims focuses on maximizing safety and efficacy, prompting an exploration natural products endowed with inherent medicinal properties. Subsequently, this work establishes a unique library plant extracts sourced from Yunnan Province, China. Screening herbal herein revealed that Salsola collina (JM10001) notably enhances both lifespan healthspan C. elegans . Further analysis via network pharmacology indicates the p53 signaling...
DNA G-quadruplexes (G4s) in vivo have been linked to cancer and other diseases such as neurological disorders. Nondestructive fast detection of endogenous G4s can provide specific real-time information, which is particular interest for clinic accurate diagnosis. However, tools probe live-cell real time are very limited. Herein, we report the design development a fluorescent molecule QIN live cells with aid new spiropyran situ switching (SIS) strategy. The lipophilic spiropyran-linked differs...
Diagnosing aging for preventative intervention generally relies on the tracking of biomarkers in resting state. However, static marker levels are insufficient to fully evaluate aging, particularly given that stress response capacity (SRC) decay is currently viewed as a critical feature aging. Therefore, we have developed dual-channel fluorescent probe ROKS capable logic-based visualization thiophenol (stressor) and HOCl (thiophenol-activated product) vivo, which provides new strategy from...
Aging is a time-dependent decline in physiological function that affects most organisms and the major risk factor for many non-communicable diseases. The early diagnosis of aging critical treatment aging-related In recent years, extensive efforts have attempted to accurately diagnose aging. To date, multiple types fluorescent probes various age-related biomarkers been developed, with aims achieving rapid, precise process evaluating efficacy anti-aging drugs. This review summarizes research...