A5011239592- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Microtubule and mitosis dynamics
- Immune cells in cancer
- Mesenchymal stem cell research
- Cytomegalovirus and herpesvirus research
- Hippo pathway signaling and YAP/TAZ
- Genomics and Rare Diseases
- Autophagy in Disease and Therapy
- Pneumonia and Respiratory Infections
- Tracheal and airway disorders
- Statistical Methods and Inference
- Cellular Mechanics and Interactions
- Fibroblast Growth Factor Research
- Genomics and Chromatin Dynamics
- Infective Endocarditis Diagnosis and Management
- Ubiquitin and proteasome pathways
- Robotics and Automated Systems
- Genetic Associations and Epidemiology
- Seaweed-derived Bioactive Compounds
- Mitochondrial Function and Pathology
- Extracellular vesicles in disease
- Machine Learning in Bioinformatics
- Mycobacterium research and diagnosis
- Genetic and phenotypic traits in livestock
Northeastern University
2024
Qilu Hospital of Shandong University
2016-2023
Shandong University
2005-2021
Stomatology Hospital
2017-2018
University of Pennsylvania
2007
University of California, Davis
2004
The expressions of many genes associated with certain periodic biological and cell cycle processes such as circadian rhythm regulation are known to be rhythmic. Identification the whose time course synchronized process may help elucidate molecular basis diseases, these gene products in turn represent drug targets relevant those diseases.We propose this paper a statistical framework based on shape-invariant model together false discovery rate (FDR) procedure for identifying periodically...
An important area of research in the postgenomics era is to relate high-dimensional genetic or genomic data various clinical phenotypes patients. Due large variability time certain events among patients, studying possibly censored survival can be more informative than treating as categorical variables. high dimensionality and censoring, building a predictive model for event difficult classification/linear regression problem. We propose develop boosting procedure using smoothing splines...
One important problem in genomic research is to identify features such as gene expression data or DNA single nucleotide polymorphisms (SNPs) that are related clinical phenotypes. Often these can be naturally divided into biologically meaningful groups genes belonging the same pathways SNPs within genes. In this paper, we propose group additive regression models and a gradient descent boosting procedure for identifying of Our simulation results show by dividing variables appropriate groups,...
Abstract Background Few studies have been conducted on the relationship between chronic periodontitis and postoperative pneumonia (POP) in patients with lung esophageal cancer. Furthermore, it remains controversial as to whether improving periodontal condition of cancer before surgery reduces incidence POP. This retrospective study was assess effects therapy prevent Methods A total 265 or complicated who underwent open thoracotomy July 2015 June 2019 were selected given choice being...
It is of vital importance to find genetic variants that underlie human complex diseases and locate genes are responsible for these diseases. Since proteins typically composed several structural domains, it reasonable assume harmful may alter structures protein affect functions eventually cause disorders. With this understanding, the authors explore possibility recovering associations between domains The define disease families on basis non-synonymous single nucleotide polymorphisms (nsSNPs)...
Kinesin superfamily protein 4 (Kif4), a microtubule-based motor protein, has been shown to participate in number of critical cellular processes, such as cell division, the intracellular transport membranous vesicles and signal transduction. However, whether KIF4 regulates vascular endothelial growth factor (VEGF) receptor 1 (VEGFR1) expression remains unknown. Thus, this study, order examine effects Kif4 on VEGFR1 RAW264.7 monocytes/macrophages, was silenced using siRNA. RT-qPCR, western...
OBJECTIVE Kinesin superfamily member 4 (Kif4), a conventional kinesin, is microtubule-dependent molecular motor. The active movement of Kif4 participates in several cellular functions, including DNA repair, mitosis, the transport macromolecules, survival neurons and even tumorigenesis progression. However, role monocyte/macrophage cells has not been reported. Our work aimed to increase understanding further investigations cells. MATERIALS AND METHODS RAW264.7 were transfected with small...
Kinesin family member 5b (Kif5b), a conventional kinesin, mainly participates in lysosome and mitochondria transportation. Some studies have indicated that Kif5b may be associated with the development of variety tumors. However, role plays oral squamous cell carcinoma (OSCC) has yet to determined. Our study aimed at investigating expression level primary OSCC discussing its clinical significance patients' outcomes.We measured 82 tissue samples immunohistochemistry. The associations between...
Pulmonary tuberculosis (PTB) is caused by Mycobacterium infection and accumulated evidence reveals the genetic context of its phenotypes. Monocyte chemoattractant protein-1 (MCP-1) rs1024611 variant shown to be associated with PTB susceptibility in some studies, but significant disparities exist. In addition, telomerase plays a key role immunocompetence, reverse transcriptase (TERT) polymorphism different diseases. We, thus, determined relationship between MCP-1 TERT rs2736100 variants...