The objective of this study was to examine how miR-145-5p contributes inhibiting the growth and movement breast cancer cells by targeting modulating ADP-ribosylation factor 6 gene, as well clarify mechanisms involved. Bioinformatics analysis used expression in samples from TCGA database. RT-qPCR performed on 25 pairs HER2-positive tissues adjacent normal tissues, SK-BR3 MCF10A cell lines. effects overexpression viability, migration, invasion were assessed using CCK-8, scratch, Transwell...

As individuals with Marfan syndrome are increasingly diagnosed earlier in life and prior to life-threatening cardiovascular events, there is opportunity study factors that influence their reproductive planning quality of life. In this 174 affected adults, the overall was reported be adequate, although it significantly decreased within spiritual/psychological domain. Approximately 62% agreed having decision-making. This view correlated age diagnosis, mitral valve prolapse, has adverse...

Objective . We attempted to evaluate the effects of probiotic‐assisted eradication cytotoxin ‐ associated gene A ( cagA )+/ vacuolating vacA ) s1m1 Helicobacter pylori H. on intestinal flora, inflammatory factors, and clinical outcomes. Methods total 180 patients with +/ H were randomly divided into two groups. Group was treated bismuth quadruple therapy (BQT). B S. boulardii in addition BQT. The distribution serum interleukin‐8 (IL‐8), IL‐17, tumor necrosis factor‐ α (TNF‐ levels, recovery...

Long noncoding RNAs (lncRNAs) are closely associated with a variety of tumors, including stomach adenocarcinoma (STAD). However, the role 5-methylcytosine- (m5C-) related lncRNAs in STAD is still uncertain. This study investigated value m5C-related prognostic evaluation and immunotherapy STAD. transcriptome sequencing data were downloaded from The Cancer Genome Atlas (TCGA) database, screened by Pearson correlation analysis. A lncRNA signature (m5CRLSig) was established using univariate...

Breast cancer is the most common invasive in women and second leading cause of death women. However, it not clear about its effective treatments. As a potential anticancer agent, grape seed procyanidins (GSPs) have been shown to inhibit proliferation various cells vitro vivo. In this study, was that GSPs significantly MCF-7 cell concentration/time-dependent manner. The flow cytometric data clearly demonstrated cycle arrest G 2 /M phase, followed by apoptosis. Moreover, also confirmed growth...

Abstract Breast cancer metastasis and invasion are both promoted by the oncoprotein Metadherin (MTDH). However, role of in breast progression its immune microenvironment. Are not clear. A bioinformatic analysis was performed to demonstrate prognostic value BC. In present study, we found that is overexpressed BC significantly correlated with individual stage, age, subclasses, menopause nodal status. overexpression associated a significant decrease OS DSS. Cox multivariate indicated an...

Metadherin (MTDH), initially discovered in primary astrocytes of the human fetus through rapid subtraction hybridization and labeled as astrocyte elevated gene‑1, represents a widely recognized oncogene present multiple types cancers. However, role MTDH different cancer remains unclear. To address this, comprehensive analysis across various cancers was conducted by utilizing databases such The Cancer Genome Atlas. that exhibits differential expression is associated with important factors...

The role of Semaphorin 7a (SEMA7A) in the initiation and progression different types cancerous lesions has been extensively studied. However, prognostic significance SEMA7A, specifically breast cancer (BC), lacks clarity.

Semaphorin7A (SEMA7A) has been found to regulate both nerve and vessel homeostasis, but its specific role in pan-cancer remains uncertain. This research seeks delve into the function clinical relevance of SEMA7A pan-cancer.

Neddylation promotes the process of ubiquitination, which plays a critical role in degradation numerous proteins, including cell cycle and apoptosis regulators. In our previous study, an increase neddylation was identified melanoma lines. present upregulation detected tissues confirmed results study on To explore mechanism by increased, enzymes that regulate were investigated. These neddylation-related regulatory are potential targets for therapy. Downregulation UBA3, subunit E1 enzyme, RNA...

Studies have shown that COX‐2 expression is upregulated in gastric cancer (GC) as well precancerous lesions and Helicobacter pylori‐induced inflammation, suggesting cyclooxygenase‐2 (COX‐2) may play an important role carcinogenesis. We attempted to investigate the of clarithromycin with tinidazole on pylori‐related gastritis from aspects clinical effect expression. From January 2016 2019, 130 patients chronic were collected grouped into observation group (OG) control (CG). Altogether, 80 OG...

AIMTo investigate the predictive factors of lymph node metastasis (LNM) in poorly differentiated early gastric cancer (EGC); to guide individual application a combination endoscopic submucosal dissection (ESD) and laparoscopic (LLND) suitable subgroup patients with EGC. METHODSWe retrospectively analyzed 138 EGC who underwent gastrectomy lymphadenectomy between January 1990 December 2015. The association clinicopathological presence LNM was by univariate multivariate logistic regression...

Objective: To assess the efficacy and safety of different opportunity Saccharomyces boulardii (S. Boulardii) Sachets combined with bismuth quadruple therapy for Helicobacter pylori(H. pylori)eradication. Methods: This experiment was a prospective study. A total 300 H. pylori-infected patients were enrolled randomized assigned into three groups. Quadruple group received pantoprazole 40 mg+bismuth potassium citrate capsule 220 mg+amoxicillin 1 000 mg+furazolidone 100 mg, bid, oral 14 days. The...

Breast cancer (BC) is the most common type of found in women. ADP-ribosylation factors (ARFs) are a group small proteins that bind to GTP and involved controlling different cellular functions. The function evolution multiple ARFs BC have remained be fully elucidated, despite existing studies on this protein family

The present study aimed to determine the efficacy and safety of pyrotinib in combination with albumin-bound paclitaxel patients HER2-positive advanced breast cancer (ABC). A total 48 diagnosed ABC were included study, these prescribed a routine clinical practice. During 21-day cycle, standard dosage was 400 mg single dose/day, which administered orally, 130 mg/m2/day on days 1, 8 15, by intravenous drip. primary endpoint progression-free survival (PFS) secondary overall response rate (ORR),...

Pulmonary tuberculosis (PTB) is caused by Mycobacterium infection and accumulated evidence reveals the genetic context of its phenotypes. Monocyte chemoattractant protein-1 (MCP-1) rs1024611 variant shown to be associated with PTB susceptibility in some studies, but significant disparities exist. In addition, telomerase plays a key role immunocompetence, reverse transcriptase (TERT) polymorphism different diseases. We, thus, determined relationship between MCP-1 TERT rs2736100 variants...

To explore the application effect of MRI and miR-134 in neo-adjuvant chemotherapy combined with breast-conserving surgery. Sixty-one patients who received surgery were collected as observation group (OG), other 53 at same time control (CG). The positive surgical margins rate, axillary lymph node metastasis 5-year survival recurrence rate expression before after treatment compared between two groups. diagnostic ability for prognostic significance explored. OG was obviously lower than that CG....