A5058406657- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Peptidase Inhibition and Analysis
- T-cell and B-cell Immunology
- Parathyroid Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Renal and related cancers
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion Channels and Receptors
- Pluripotent Stem Cells Research
- Advanced Glycation End Products research
- Circular RNAs in diseases
- Endoplasmic Reticulum Stress and Disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Axon Guidance and Neuronal Signaling
- Urticaria and Related Conditions
- Ion Transport and Channel Regulation
- Cancer Mechanisms and Therapy
- Cancer Treatment and Pharmacology
- Cancer Immunotherapy and Biomarkers
- Calcium signaling and nucleotide metabolism
- Adipose Tissue and Metabolism
- TGF-β signaling in diseases
- Kidney Stones and Urolithiasis Treatments
Hebei Medical University
2024-2025
Xingtai People's Hospital
2024-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2015-2024
Xi'an Jiaotong University
2014-2015
The objective of this study was to examine how miR-145-5p contributes inhibiting the growth and movement breast cancer cells by targeting modulating ADP-ribosylation factor 6 gene, as well clarify mechanisms involved. Bioinformatics analysis used expression in samples from TCGA database. RT-qPCR performed on 25 pairs HER2-positive tissues adjacent normal tissues, SK-BR3 MCF10A cell lines. effects overexpression viability, migration, invasion were assessed using CCK-8, scratch, Transwell...
Objective This study was to investigate whether sorafenib can inhibit the progression of renal fibrosis and possible mechanisms this effect. Methods Eight-week-old rats were subjected unilateral ureteral obstruction (UUO) intragastrically administered sorafenib, while control sham groups vehicle for 14 or 21 days. NRK-52E cells treated with TGF-β1 24 48 hours. HE Masson staining used visualize tissue in each group. The expression α-SMA E-cadherin kidney performed using immunohistochemistry...
Abstract Background The objective of this study is to investigate the clinical and pathological differences between patients with IgA nephropathy (IgAN) vasculitis associated nephritis (IgAVN). Methods A total 253 IgAN 71 IgAVN were retrospectively included in study, laboratory data collected analysed. Results Compared group, months from onset kidney biopsy significantly prolonged because lack obvious symptoms such as rash, abdominal symptoms, joint pain (13.5 ± 26.6 vs. 10.2 31.6 months, P...
Purpose: The purpose of this study was to assess the effectiveness and side effects pegylated liposomal doxorubicin (PLD) epirubicin in neoadjuvant treatment for HER2-negative breast cancer. Patients methods: authors performed a retrospective analysis 107 patients diagnosed with cancer who underwent TA (PLD 35 mg/m 2 , docetaxel 75 ) or TE (epirubicin 100 chemotherapy (NAC) from January 2021 December 2022. PLD administered 57 instances, while used 50 cases. clinicopathological features,...
Metadherin (MTDH), initially discovered in primary astrocytes of the human fetus through rapid subtraction hybridization and labeled as astrocyte elevated gene‑1, represents a widely recognized oncogene present multiple types cancers. However, role MTDH different cancer remains unclear. To address this, comprehensive analysis across various cancers was conducted by utilizing databases such The Cancer Genome Atlas. that exhibits differential expression is associated with important factors...
The role of Semaphorin 7a (SEMA7A) in the initiation and progression different types cancerous lesions has been extensively studied. However, prognostic significance SEMA7A, specifically breast cancer (BC), lacks clarity.
Semaphorin7A (SEMA7A) has been found to regulate both nerve and vessel homeostasis, but its specific role in pan-cancer remains uncertain. This research seeks delve into the function clinical relevance of SEMA7A pan-cancer.
Objective KCa3.1 channel participates in many important cellular functions. This study planned to investigate the potential involvement of premature senescence, myofibroblast phenotype transition and proliferation mesangial cells. Methods & Materials Rat cells were cultured together with TGF-β1 (2 ng/ml) + TRAM-34 (16 nM) separately for specified times from 0 min 60 min. The without treatment served as controls. location channels was determined Confocal laser microscope, cell cycle assessed...
Background: Transforming growth factor-β1 (TGF-β1) is a polypeptide member of the transforming factor β superfamily cytokines and performs many cellular functions. Its overexpression may lead to renal fibrosis. Aim: This study planed investigate effects TGF-β1 on cell cycle phenotype mesangial cells. Methods: Rat cells were cultured together with different concentrations (0, 1, 2, 5, 10 ng/mL) for specified times from 0 min 72 h. ng/mL served as controls. Cell cycles assessed by flow...
Vascular calcification (VC) is a major contributor of cardiovascular dysfunction in chronic renal failure (CRF). Citrate binds calcium and inhibits the growth crystals. This present study intends to evaluate effect citrate on VC adenine-induced CRF rats. The rats were randomly divided into five groups: control group, model with low-dose treatment (216 mg/kg) high-dose (746 mg/kg). euthanized at 5 weeks their blood aorta detection. results showed that serum level urea nitrogen, creatinine,...
<b><i>Background/Aims:</i></b> FK506 is an immunosuppressive drug and a calcineurin inhibitor that has been widely used in kidney disease recent years. shows wide range of biological pharmaceutical effects; however, the mechanism its anti- proliferative effect not well elucidated. An IgA nephropathy (IgAN) model was to generate mesangial cell proliferation model. This study aims examine on IgAN rats underlying mechanisms. <b><i>Methods:</i></b>...
Background/Aims: Mesangial cell proliferation and extracellular matrix accumulation (ECM) deposition play an important role in the pathogenesis of glomerulosclerosis. TRPC PPAR-γ can regulate proliferation. Angiotensin II (AngII) induce mesangial affect expression. However, mechanism has not been fully elucidated. This study was designed to investigate effect rosiglitazone (RSG) rat glomerular cells (HBZY-1) that were stimulated by AngII underlying mechanisms. Methods: Immunofluorescence...
The imbalance of T helper 17 (Th17) and regulatory (Treg) cells exists in the occurrence development various diseases. Endoplasmic reticulum stress (ERS) is an important self-protective cellular response to harmful stimuli, such as uremic environment. objective this study was investigate Th17/Treg cell balance ERS a environment analyze relationship between them. (1) rat spleen lymphocytes were extracted treated with thapsigargin (inducer ERS) sodium citrate. proportion Th17 Treg then...
Breast cancer (BC) is the most common type of found in women. ADP-ribosylation factors (ARFs) are a group small proteins that bind to GTP and involved controlling different cellular functions. The function evolution multiple ARFs BC have remained be fully elucidated, despite existing studies on this protein family
ABSTRACT Background: Primary membranous nephropathy (pMN) is the most common pathological type of nephrotic syndrome in adults. Therefore, it imperative to find a better combination therapy with fewer adverse effects for patients pMN. Methods: This study enrolled 84 biopsy-proven pMN and syndrome. Thirty low-dose multitarget regimen (LDMT) group received glucocorticoids along tacrolimus mycophenolate mofetil, 54 prednisone plus intravenous cyclophosphamide (PC) corticosteroids...
ABSTRACT Background: Primary membranous nephropathy (pMN) is treated with glucocorticoids or immunosuppressive agents, depending on the disease severity. However, treating pMN type 2 diabetes mellitus (T2DM) remains challenging. Methods: We retrospectively collected and analyzed data of patients diagnosed T2DM. The low-dose multitarget regimen consists prednisone (10 mg/d), tacrolimus (0.05 mg/kg/d, blood concentration 5–10 ng/mL), mycophenolate mofetil (1 g/d); cyclophosphamide (CTX)...
Abstract objective : To investigate the effect of wild type p53-induced phosphatase 1 (Wip1) on regulation phenotype macrophages and to participate in renal fibrosis. Method RAW264.7 were stimulated by lipopolysaccharide (LPS) IFN-γ for 24h into M1 with high expression iNOS TNF-α. interleukin 4(IL-4) 24 h induce M2 Arg-1 CD206. In meantime, transduced Wip1 lentivirus overexpressing it, RNAi reducing expression. Furthermore, after coculture transformed mice primary tubular epithelial cells,...