A5101486028- HER2/EGFR in Cancer Research
- Nutritional Studies and Diet
- Kidney Stones and Urolithiasis Treatments
- Ferroptosis and cancer prognosis
- Diet and metabolism studies
- Telomeres, Telomerase, and Senescence
- Breast Lesions and Carcinomas
- Neonatal Respiratory Health Research
- Dietary Effects on Health
- Nutrition and Health in Aging
- Parathyroid Disorders and Treatments
- Genetics, Aging, and Longevity in Model Organisms
- Mesenchymal stem cell research
- Natural Compounds in Disease Treatment
- Bipolar Disorder and Treatment
- Lymphatic System and Diseases
- Pediatric health and respiratory diseases
- Tuberculosis Research and Epidemiology
- Renal and Vascular Pathologies
- Gastroesophageal reflux and treatments
- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
- Neonatal and fetal brain pathology
- Eating Disorders and Behaviors
- Autophagy in Disease and Therapy
Xijing Hospital
2024-2025
National Clinical Research Center for Digestive Diseases
2024-2025
Air Force Medical University
2024-2025
Harbin Medical University
2021-2024
Chinese Research Academy of Environmental Sciences
2023
Nanjing Second Hospital
2021
Nanjing University
2014-2021
Beijing Children’s Hospital
2020
Capital Medical University
2020
Baoding People's Hospital
2017-2019
This study aimed to assess the association of past obesity and BMI trajectories with cancer mortality in National Health Nutrition Examination Survey. Past was identified based on maximum body weight, change were determined by latent class trajectory modeling (LCTM). Cox regression used mortality. A total 4,058 patients participated this study, which 46.3% obesity, resulting a significantly lower risk compared participants who not (HR = 0.92, 95% CI: 0.92-0.93, P < 0.01). The LCTM five BMI,...
Aims: Investigating the impact of stemness-related circadian rhythm disruption (SCRD) on hepatocellular carcinoma (HCC) prognosis and its potential as a predictor for immunotherapy response. Background: Circadian has been linked to tumor progression through effect stemness cancer cells. Objective: Develop novel signature SCRD accurately predict clinical outcomes immune therapy response in patients with HCC. Methods: The degree HCC was assessed based index (mRNAsi). co-expression genes...
Loss of peritubular capillaries is a notable feature progressive renal interstitial fibrosis. Astaxanthin (ASX) natural carotenoid with various biological activities. The present study aimed to evaluate the effect ASX on unilateral ureteral obstruction (UUO)‑induced fibrosis in mice. For that purpose, mice were randomly divided into five treatment groups: Sham, 100 mg/kg, UUO, UUO + 50 mg/kg and mg/kg. was administered for 7 or 14 days following UUO. results demonstrated UUO‑induced...
Abstract Background Cysts of Artemia can remain in a dormant state for long periods with very low metabolic rate, and only resume their development the approach favorable conditions. The post-diapause is complicated process involving variety biochemical events. However, intrinsic mechanisms that regulate this are unclear. Results Herein we report specific activation an AMP-activated protein kinase (AMPK) developmental . Using phospho-AMPKα antibody, AMPK was shown to be phosphorylated...
Gallstones are strongly associated with eating occasion (EO) and energy distribution, but few studies have addressed this aspect. Therefore, we utilize the data from 2017 to 2018 National Health Nutrition Examination Survey (NHANES) explore association between temporal patterns distribution incidence of gallstones.
Vascular calcification (VC) is a major contributor of cardiovascular dysfunction in chronic renal failure (CRF). Citrate binds calcium and inhibits the growth crystals. This present study intends to evaluate effect citrate on VC adenine-induced CRF rats. The rats were randomly divided into five groups: control group, model with low-dose treatment (216 mg/kg) high-dose (746 mg/kg). euthanized at 5 weeks their blood aorta detection. results showed that serum level urea nitrogen, creatinine,...
Depressive disorder is a debilitating psychiatric mental disease. However, no biological methods are used for the diagnosis of this disorder. Proteomic approaches biomarker discovery may provide an important objective tool diagnostics depression. This study aimed to identify serum protein biomarkers depressive disorder.We screened potential depression in 175 samples from 86 patients and 89 healthy controls. Serum spectrums were detected by matrix-assisted laser desorption ionization time...
Objective This study aimed to evaluate endothelial microparticles (EMPs) as a potential prognostic marker in hemolytic disease of the Chinese neonate. Methods We compared 29 newborns with ABO newborn (ABO HDN), 22 Rh HDN, and 21 healthy matched mother infant blood groups (controls). Markers hemolysis von Willebrand factor antigen (vWF Ag) were analyzed. EMP (CD144+) levels measured before after therapy. Results vWF Ag pretherapy higher HDN than control group. Additionally, significantly...
Interleukin (IL)-37 has an important role in autoimmune diseases by suppressing immunity and inflammation; however, the of IL-37 immune thrombocytopenia (ITP) remained largely elusive. The present study aimed to investigate expression its potential pathogenesis ITP. plasma levels peripheral blood mononuclear cells patients with active ITP, ITP remission healthy controls were measured ELISA reverse transcription-quantitative PCR, respectively. treated without glucocorticoids also determined...
Objective: To study the clinical effect of ganglioside (GM) and fructose-1, 6-diphosphate (FDP) on neonatal heart brain injuries after asphyxia.Methods: Ninety-one neonates with asphyxia were randomly divided into an observation group a control group. Both groups given symptomatic treatment as soon possible. On this basis, was 200 mL 5% glucose injection 20 mg GM 250 mg/kg·d FDP by intravenous infusion. The above two drugs once day for 14 days. injection, 2 cerebrolysin infusion,...
Glioblastoma multiforme (GBM) is a highly, malignant tumor of the primary central nervous system. Patients diagnosed with this type have poor prognosis. Lymphocyte activation plays important roles in development cancers and its therapeutic treatments.We sought to identify an efficient lymphocyte activation-associated gene signature that could predict progression prognosis GBM.We used univariate Cox proportional hazards regression stepwise algorithm develop training dataset (TCGA, n = 525)....
To explore the correlation between of regulatory T cells, Th17 cells and prognosis children with aplastic anemia.The clinical data 13 anemia (AA) treated by antithymocyte globulin (ATG) combined Cyclosporine in Beijing Children's Hospital, Capital Medical University from January 2017 to 2018 were analyized retrospectively. The changes cell expression level peripheral blood AA before after IST for 6 12 month compared analyzed. SPSS 19.0 statistical package was used analysis.Compared pre-IST,...