A5072577051- Diabetes and associated disorders
- Cancer-related molecular mechanisms research
- Diet, Metabolism, and Disease
- Pancreatic function and diabetes
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Ferroptosis and cancer prognosis
- Head and Neck Cancer Studies
- Circular RNAs in diseases
- Mitochondrial Function and Pathology
- Heat shock proteins research
- Cancer therapeutics and mechanisms
- Neuroblastoma Research and Treatments
- Pancreatitis Pathology and Treatment
- Ideological and Political Education
- Peptidase Inhibition and Analysis
- Lung Cancer Research Studies
- Cervical and Thoracic Myelopathy
- Computational Drug Discovery Methods
- Cancer-related gene regulation
- Prenatal Screening and Diagnostics
- Photoreceptor and optogenetics research
Nanjing Drum Tower Hospital
2024
Shihezi University
2024
People's Hospital of Xinjiang Uygur Autonomous Region
2024
Wuhan Third Hospital
2024
Shanghai Jiao Tong University
2019-2023
Tongji University
2023
Peking Union Medical College Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
The First Hospital of Changsha
2023
Sichuan Agricultural University
2023
Acute myocardial infarction (AMI) is the leading cause of death worldwide. Ischemia-reperfusion (I/R) injury considered most common contributor to AMI. Hirsutine has been shown protect cardiomyocytes against hypoxic injury. The present study investigated whether hirsutine improved AMI induced by I/R and underlying mechanisms. In our study, we used a rat model rats were given daily (5, 10, 20 mg/kg) gavage for 15 days before Detectable changes observed in infarct size, mitochondrial function,...
Abstract Immune checkpoint inhibitors (ICIs) are novel treatments that significantly improve the survival time of MIBC patients, but immunotherapeutic responses different among patients. Therefore, it is urgent to find predictive biomarkers can accurately identify patients who sensitive ICIs. In this study, we computed relative abundances 24 immune cells based on expression profiles using single‐sample gene set enrichment analysis (ssGSEA). Unsupervised clustering was performed classify into...
Previous research has demonstrated the feasibility of repairing nerve defects through acellular allogeneic grafting with bone marrow mesenchymal stem cells. However, adult tissue–derived cells encounter various obstacles, including limited tissue sources, invasive acquisition methods, cellular heterogeneity, purification challenges, senescence, and diminished pluripotency proliferation over successive passages. In this study, we used induced pluripotent cell-derived cells, known for their...
Abnormal expressions of long noncoding RNAs (lncRNAs) are very common in clear cell renal carcinoma (ccRCC), and some these have been reported to be highly correlated with prognosis ccRCC patients. "edgeR" AND "DEseq" R packages were used explore differentially expressed genes (DEGs) between normal tumor tissues samples from The Cancer Genome Atlas (TCGA). Univariable Cox survival analysis, robust likelihood-based model multivariable regression analysis identify prognostic lncRNAs construct...
As the first of 15 Healthy China initiatives, Health Education Initiative has crucially important goal improving citizens' health literacy. There are two key activities in initiative for The is to establish a mechanism dissemination sciences knowledge through development national and provincial databases expertise resource accessible knowledge. second education promotion performance evaluation medical institutions personnel. In this paper, we analyzed content strategies these educational activities.
Severe acute pancreatitis (SAP) is an digestive system disease with high morbidity mortality and hospitalization rate worldwide, due to various causes unknown pathogenesis. In recent years, a large number of studies have confirmed that non-coding RNAs (ncRNAs) play important role in many cellular processes occurrence. However, the underlying mechanisms based on function ncRNAs, including long noncoding RNA (lncRNA) circular (circRNA), SAP remain unclear. this study, we performed...
The outbreak of COVID-19 has spread quickly across 114 countries/territories/areas in six continents worldwide and been announced as a pandemic by WHO. This study analyzed global epidemiological trends, examined impact the on health security, diplomacy, social environment China, provided short- long-term strategic policy recommendations for China's subsequent preparedness responses.
Primary malignant melanoma of the esophagus (PMME) is a rare malignancy and prognosis typically poor. There currently lack appropriate treatment strategies clear guidance. The current study presents case 65-year-old female with two-month history progressive dysphagia, investigations which resulted in diagnosis PMME. patient was treated radical transhiatal esophagectomy subcarinal lymphadenectomy followed by combined chemoimmunotherapy. remains alive no evidence tumor progression at 12-month...
Severe acute pancreatitis (SAP) is the most serious type of with high morbidity and mortality. The underlying mechanism behind SAP pathogenesis complex remains elusive. Circular RNAs (circRNAs) are emerging as vital regulators gene expression in various diseases by sponging microRNAs (miRNAs). However, roles circRNAs pathophysiology remain unknown. In present study, next-generation RNA sequencing was utilized to identify circRNA transcripts pancreatic tissues from three mice matched normal...
Ischemic stroke (IS) is a major neurological disease with high fatality and residual disability burdens. Long noncoding RNAs (lncRNAs) have been found to play an important role in IS. However, the roles significance of most lncRNAs IS are still unknown. This study was performed identify differentially expressed (DE) using lncRNA microarray whole blood samples patients suffering from acute cerebral ischemia. Bioinformatics analyses, including GO, KEGG pathway enrichment analysis, proximity...
Purpose: Hyperthermia induces tumour cell apoptosis through the mitochondrial apoptotic pathway; however, signal transduction mechanism underlying this process still needs to be fully elucidated. Phospholipid scramblase 3 (PLS3), a target of protein kinase C-δ (PKC-δ), resides in mitochondria and plays pivotal roles regulating response. Activated PLS3 facilitates cardiolipin (CL) translocation from inner membrane outer leaflet triggers apoptosis.
Abstract Information tech has been integrated into all aspects of college students’ study and life, which puts forward higher demands for the political & thought management students. However, there are still many problems deficiencies in education students, urgently needs reform. Based on this, this paper first analysis studies development status network university students based info, then gives strategy info.
Noninvasive prenatal testing (NIPT) is increasingly recognized and utilized in the antenatal care field. In current study, we aimed to evaluate clinical application compare test outcomes of two generations currently used NIPT techniques for detecting fetal chromosome abnormalities a high-risk population. A total 7,252 pregnant women were included from twenty-one hospitals January 2015 September 2017. maternal blood sample each participant was collected DNA sequencing. Group I received first...
Abstract Bladder cancer (BCa) is a common malignant tumor of urinary system with few treatments, so more useful therapeutic targets are still needed. Antitumor effects tristetraprolin (TTP) have been explored in many type tumors, but its roles bladder unknown until now. In this study, public expression profiles and tissue microarray analysis showed that TTP mRNA protein levels decreased BCa relative to the normal tissue. To explore biological functions BCa, 488 target genes, which could be...
Kinesin superfamily protein 4 (Kif4), a microtubule-based motor protein, has been shown to participate in number of critical cellular processes, such as cell division, the intracellular transport membranous vesicles and signal transduction. However, whether KIF4 regulates vascular endothelial growth factor (VEGF) receptor 1 (VEGFR1) expression remains unknown. Thus, this study, order examine effects Kif4 on VEGFR1 RAW264.7 monocytes/macrophages, was silenced using siRNA. RT-qPCR, western...
Many researches indicated that long non-coding RNAs (lncRNAs) were involved in the malignant progression of tumors, including Adrenocortical Carcinoma (ACC). However, as for most lncRNAs, their biological behaviors and molecular mechanism remain unclear ACC. In present research, weighted gene co-expression network analysis (WGCNA) was used to identify pathologically relevant gene, lncRNAs. By comparing expressions GSE61359 tumors normal controls, intergenic non-protein coding RNA 1234...
This study aimed to investigate the clinical features, pathogenic gene variants, and potential genotype-phenotype correlations in Chinese patients with hereditary spherocytosis (HS).