A5101487522- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Cancer Cells and Metastasis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ovarian cancer diagnosis and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Intraocular Surgery and Lenses
- Adrenal and Paraganglionic Tumors
- Corneal surgery and disorders
- Pediatric health and respiratory diseases
- Neurological Disease Mechanisms and Treatments
- Immune Response and Inflammation
- Mechanisms of cancer metastasis
- Psoriasis: Treatment and Pathogenesis
- Aldose Reductase and Taurine
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cancer Risks and Factors
- Pancreatic and Hepatic Oncology Research
- Adenosine and Purinergic Signaling
- Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Acute Myeloid Leukemia Research
- Inflammatory mediators and NSAID effects
Wenzhou Medical University
2024-2025
First Affiliated Hospital of Wenzhou Medical University
2024-2025
Chinese Academy of Sciences
2024-2025
Second Affiliated Hospital of Dalian Medical University
2018-2025
Dalian Institute of Chemical Physics
2024-2025
Dalian Medical University
2014-2025
Wannan Medical College
2024
Taizhou People's Hospital
2019-2023
Nantong University
2019-2023
Nanjing Drum Tower Hospital
2019-2023
Abstract Immune checkpoint inhibitors (ICIs) are novel treatments that significantly improve the survival time of MIBC patients, but immunotherapeutic responses different among patients. Therefore, it is urgent to find predictive biomarkers can accurately identify patients who sensitive ICIs. In this study, we computed relative abundances 24 immune cells based on expression profiles using single‐sample gene set enrichment analysis (ssGSEA). Unsupervised clustering was performed classify into...
Sepsis-associated encephalopathy (SAE) is a severe and frequent septic complication, characterized by neuronal damage as key pathological features. The astrocyte–microglia crosstalk in the central nervous system (CNS) plays important roles various neurological diseases. However, how astrocytes interact with microglia to regulate injury SAE poorly defined. In this study, we aim investigate molecular basis of underlying pathogenesis also explore new therapeutic strategies targeting devastating...
Gastric cancer patients are prone to lower extremity deep vein thrombosis (DVT) after surgery, which is an important cause of death in postoperative patients. Therefore, it particularly find a suitable way predict the risk occurrence DVT GC This study aims explore effectiveness using machine learning (ML) assisted radiomics build imaging models for prediction surgery. Included this retrospective were eligible who underwent surgery GC. CT data from these collected and divided into training...
Purpose. To evaluate the neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio(PLR) value in development of branch retinal vein occlusion (BRVO)patients.81 patients with BRVO 81 age sex-matched subjects were recruited as control group. The diagnosis was confirmed under comprehensive ophthalmologic examinations. NLR PLR parameters obtained from peripheral blood recorded.Both mean significantly higher group compared (p < 0.001). In ROC analysis, AUC for 0.82, >2.48 predicted a...
Retinal imaging being a potential biomarker for Alzheimer's disease is gradually attracting the attention of researchers. However, association between retinal parameters and AD neuroimaging biomarkers, particularly structural changes, still unclear. In this cross-sectional study, we recruited 25 cognitively impaired (CI) 21 normal (CN) individuals. All subjects underwent layer thickness microvascular measurements with optical coherence tomography angiography (OCTA). Gray matter white (WM)...
Abstract Background Honokiol (HKL), a natural extract of the bark magnolia tree and an activator mitochondrial protein sirtuin-3 (SIRT3), has been proposed to possess anti-inflammatory effects. This study investigated inhibitory effects HKL on T helper (Th) 17 cell differentiation in colitis. Methods Serum biopsies from 20 participants with ulcerative colitis (UC) 18 healthy volunteers were collected for test serum cytokines, flow cytometry analysis (FACS), relative messenger RNA (mRNA)...
To elucidate the relationship between macular sensitivity and time in range (TIR) obtained from continuous glucose monitoring (CGM) measures diabetic patients with or without retinopathy (DR).This was a cross-sectional study including 100 eyes of non-DR 60 DR patients. An advanced microperimetry used to quantitate retinal mean (MS) fixation stability central macula. TIR 3.9-10.0 mmol/L evaluated CGM. Pearson coefficient analysis multiple linear regression were assess correlation...
Purpose. To assess the clinical efficiency of a novel ophthalmic viscosurgical device-free (OVD-free) method for intraocular collamer lens (EVO-ICL) implantation in myopic eyes. Methods. In this study, 40 patients underwent ICL both eyes: one eye traditional implantation, and other OVD-free (pure) implantation. Preoperative postoperative UDVA, BCVA, equivalent spherical degree (SE), IOP, visual quality index, subjective scale, corneal endothelial cell density (ECD), operation time,...
Purpose . To examine the difference in vitreal protein profiles of patients with proliferative diabetic retinopathy (PDR) and without preoperative intravitreal conbercept (IVC) treatment. Methods Liquid chromatography-tandem mass spectrometry- (LC-MS/MS-) based proteomic methods were used to determine vitreous humor PDR treated (IVC group;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>9</mml:mn></mml:math>) (PDR...
Abstract Background The etiology of inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's (CD), is not completely clear, but its pathogenesis closely related to T helper 17 (Th17) cells. Several histone deacetylase (HDAC) inhibitors have been shown exert potent anti‐inflammatory effects modulate Th17 cell polarization. Owing the large variety broad expression HDACs, finding specific therapeutic targets for IBD clinical importance. Methods proportions cells...
Abstract Background The oncogene a disintegrin and metalloproteinase 9 (ADAM9) was up‐regulated in ovarian cancer tissues, the present study aims to explore potential diagnostic prognostic value of ADAM9 (OC). Methods A total 30 paired fresh OC tumor tissues paired‐adjacent normal tissue, 90 formalin‐fixed paraffin‐embedded (FFPE) samples adjacent tissue were collected. expression FFPE examined by immunohistochemical methods, mRNA RT‐qPCR methods. Receiver operating characteristics curve...
Abstract Bladder cancer (BCa) is a common malignant tumor of urinary system with few treatments, so more useful therapeutic targets are still needed. Antitumor effects tristetraprolin (TTP) have been explored in many type tumors, but its roles bladder unknown until now. In this study, public expression profiles and tissue microarray analysis showed that TTP mRNA protein levels decreased BCa relative to the normal tissue. To explore biological functions BCa, 488 target genes, which could be...
Background. Chronic obstructive pulmonary disease (COPD) patients are particularly vulnerable to acute exacerbation, resulting in a huge socioeconomic burden. Objective. In this study, we evaluated the value of serum secreted frizzled-related protein 1 (SFRP1) and Clara cell-secreted (CC16) predicting risk exacerbations with COPD. Methods. The study included 123 COPD admitted our hospital from May 2020 June 2021, including 65 stable stage (STCOPD group), 58 exacerbation (AECOPD 60 healthy...
Abstract Background: To assess the clinical efficiency of a novel ophthalmic viscosurgical device-free (OVD-free) method for intraocular collamer lens (EVO-ICL) implantation in myopic eyes. Methods: In this retrospective cohort study, 40 eyes underwent standard ICL implantation, and OVD-free (Pure) implantation. Preoperative postoperative uncorrected distance visual acuity (UDVA), best-corrected (BCVA), equivalent spherical degree (SE), pressure (IOP), quality index, subjective scale,...
Sepsis-associated encephalopathy (SAE) is a severe and frequent septic complication with high morbidity mortality. The main symptoms of SAE are cognitive emotional dysfunctions, characterized by neuronal damage as key pathological changes. astrocytes–microglia crosstalk in the central nervous system (CNS) plays important roles neuropathogenesis. However, it poorly defined how astrocytes interact microglial cells to regulate injury SAE. Here, we found activated microglia exhibited close...
<b><i>Introduction:</i></b> We characterized the role of aminoacyl-tRNA synthetase-interacting multifunctional protein 1 (AIMP1) in retinal inflammation and apoptosis regulation, both vivo vitro. In addition, we used clinical specimens to show relationship between AIMP1 development diabetic retinopathy (DR). <b><i>Objective:</i></b> To elucidate DR. <b><i>Methods:</i></b> A AIMP1-specific knockout (KO) C57 mouse model...
Copy number aberrations (CNA) are the core determinants for diagnosis, risk stratification and prognosis in acute myeloid leukemia (AML) myelodysplastic syndrome (MDS). In this study, a shallow whole-genome sequencing-based assay, LeukoPrint, was utilized to depict genomic CNA profiles from bone marrow of 137 newly diagnosed AML/MDS patients. It demonstrated 98.1% concordance with cytogenetics and/or fluorescence situ hybridization (FISH). is advantageous detecting CNAs short segments (1 Mb)...
Abstract Purpose: To elucidate the role of TGF-β2 and Fenofibrate in DR concomitant with HUA. Methods: In vitro, human retinal endothelial cells (HRECs) were incubated high glucose(HG), HUA HG mixed respectively. The apoptosis rate was evaluated by TUNEL assay Capase-3 activity. VEGF detected Western blot real-time PCR. therapeutic effect revealed detecting level peroxisome proliferator activated receptor a(PPARa) through Results: cellular apoptosis, TGF-β conducted to increase most...