The overall survival of patients with pancreatic cancer is extremely low. Despite multiple large-scale studies, identification predictors patient remains challenging. This study aimed to investigate the prognostic factors for cancer.The clinical data 625 treated at Shengjing Hospital China Medical University from January 2013 December 2017 were collected.Of patients, 569 followed 1 75 months. median was 9.3 1-, 3-, and 5-year rates 37.8%, 15.1%, 10.5%, respectively. Cox proportional hazards...

TGF-β plays a central role in epithelial-mesenchymal transition (EMT), which is highly conserved and reversible process that governs tumor development, invasion metastasis.Through this transition, the epithelial cell acquires migratory behavior allows it to move away from community integrate into surrounding tissue.The cells lost phenotypes including change of polarity loss specialized cell-cell contacts, related with shortage E-cadherin directly.The increasing reports indicated...

Abstract Background In ageing societies such as the United States, evaluating incidence and survival rates of cancer in older adults is essential. This study aimed to analyse individuals aged 55 years or States. Methods retrospective (1975–2019) was conducted using combined registry data from Surveillance, Epidemiology, End Results database. Data 9, 12, 17 Registries (Nov 2021 Sub) datasets were used. 2019, than overall population 1322.8 382.1 per 100,000 population, respectively. From 2000...

Purpose. To evaluate the neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio(PLR) value in development of branch retinal vein occlusion (BRVO)patients.81 patients with BRVO 81 age sex-matched subjects were recruited as control group. The diagnosis was confirmed under comprehensive ophthalmologic examinations. NLR PLR parameters obtained from peripheral blood recorded.Both mean significantly higher group compared (p < 0.001). In ROC analysis, AUC for 0.82, >2.48 predicted a...

The importance of N6-methyladenosine (m6A) modification in tumorigenesis and progression have been highlighted. This study aimed to investigate the insulin receptor substrate 1 (

Herpes Simplex Virus 1 (HSV-1) invades corneal nerves upon its infection of the cornea and then establishes latency in trigeminal ganglion (TG). The latent virus TG is often reactivated travels back to cornea, causing recurrent herpes simplex keratitis (HSK). entry HSV-1 into nerve considered initial step resulting HSK recurrence. Several gD gB receptors have been identified, including nectin-1, medium (HVEM) 3-O-sulfated heparan sulfate (3-OS-HS) as receptors, non-muscle myosin heavy chain...

Abstract Background Gene mutations play critical roles in tumorigenesis and cancer development. Our study aimed to screen survival-related explore a novel gene signature predict the overall survival pancreatic cancer. Methods Somatic mutation data from three cohorts were used identify common with Kaplan-Meier curves. RNA-sequencing for prediction. First, Weighted Co-expression Network Analysis was conducted candidate genes. Then, ICGC-PACA-CA cohort applied as training set TCGA-PAAD external...

This research was designed to determine the association of serum lipid peroxidation products with disease severity in patients abdominal aortic aneurysm (AAA). In total, 76 pairs AAA cases as well matched controls were enrolled our using propensity score matching (PSM). And their malondialdehyde (MDA), hydroperoxide (LPO), and glutathione peroxidase (GSH-Px) levels also detected through enzyme-linked immunosorbent assay (ELISA). Additionally, relative clinical data participants extracted....

Frailty and its components are proposed to associate with kidney function, but little attention is paid the significance of changes in their status on rapid loss function. This study aimed investigate association between frailty renal

Abstract Background Cancer stem cells are pivotal in cancer progression and therapy, including lung adenocarcinoma (LUAD). High NCAPG level is implicated malignant tumorigenesis, but investigations on LUAD warranted. Hence, projecting the impact of cell stemness targeted therapy for essence. Methods Bioinformatics analyzed expression tissues. qRT‐PCR assayed cells. CCK‐8 assessed viability sphere‐forming assay measured ability. Western blot cell‐related markers (CD133, CD44, Oct‐4) specific...

Few studies have explored correlations between metabolic syndrome (MetS) alterations and renal deterioration in longitudinal cohorts. We aim to investigate associations MetS recovery/development rapid estimated glomerular filtration rate (eGFR) decline the China Health Retirement Longitudinal Study (CHARLS). cohort study. This study is a secondary analysis of CHARLS. After excluding individuals with age <45 years old, eGFR <60 mL/min/1.73 m2 clinician-reported malignant tumour, heart...

Abstract Background Crohn's disease (CD) often presents with malnutrition due to the impaired mucosal barrier accelerating loss of protein. The edema index can indicate protein consumption. This study aims confirm whether could be a nutritional assessment for CD patients. Methods was conducted at Xiangya Hospital Central South University between May 2023 and July 2023, including patients control group. In both groups, bioelectrical impedance analysis performed, defined as extracelluar...

Introduction: Limited data exist on links between glycemic markers and cardiac autonomic neuropathy (CAN) across the dysglycemia spectrum (including prediabetes diabetes). We assessed associations of multiple with heart rate (HR) CAN, measured via variability (HRV). Methods: This cross-sectional analysis included 2,266 participants who attended a 14-year follow up DPPOS visit. evaluated (fasting glucose, HbA1c HOMA-IR) HR HRV (standard deviation all normal-to-normal intervals [SDNN], root...

Abstract Background Immune checkpoint inhibitors (ICI) PD-1/PD-L1 antibody are key drugs for the treatment of cancer. Bispecific is one strategies aimed to meet clinical needs cancer patients who resistant or refractory from ICI treatment. TIM-3, next generation targets, co-expressed on exhausted T cells with PD-1. It also expressed by innate immune populations, including NK and DC. Dual blocking PD-1 TIM-3 not only but DC, may achieve better benefit Method A bivalent bispecific (Bis5) was...

Abstract Background To analyze the optical coherence tomography angiography(OCTA) and microperimetry features in diabetic patients without retinopathy(NDR group) with early stage of non-proliferative retinopathy(NPDR group). Methods This was a cross-sectional study including 24 eyes NDR group, NPDR healthy volunteers(control OCTA used to measure foveal avascular zone(FAZ), vessel flow density superficial capillary plexus(SCP) deep plexus(DCP) macular area(3×3mm). The latest version...

Abstract Background To explore the ocular vascular variation involvement in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) cohorts. The measurement of retinal vessel density was performed by spectral-domain optical coherence tomography angiography (OCTA). Methods This study including 24 eyes normal cognitively individuals (NC group), 23 MCI patients (MCI group) 11 AD (AD measured with OCTA. Mean arterial pressure (MAP) mean perfusion (MOPP) were calculated based on systemic...