A5068561889- Inflammasome and immune disorders
- Immune Response and Inflammation
- Pancreatitis Pathology and Treatment
- Hydrogen's biological and therapeutic effects
- Heme Oxygenase-1 and Carbon Monoxide
- Pediatric Hepatobiliary Diseases and Treatments
- Biomarkers in Disease Mechanisms
- Antimicrobial Peptides and Activities
- Neonatal Respiratory Health Research
- Apelin-related biomedical research
- Ion channel regulation and function
- Traumatic Brain Injury and Neurovascular Disturbances
- Sulfur Compounds in Biology
- Mangiferin and Mango Extracts
- Neonatal Health and Biochemistry
- Liver Disease Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Pharmacological Effects of Natural Compounds
- Big Data Technologies and Applications
- Extracellular vesicles in disease
- Management of metastatic bone disease
- Biochemical effects in animals
- Liver Disease and Transplantation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Biliary and Gastrointestinal Fistulas
Yili Normal University
2024
North China Electric Power University
2024
China Electric Power Research Institute
2024
University of Electronic Science and Technology of China
2020-2024
The Fifth People’s Hospital of Suzhou
2023
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2022
Chengdu University
2021
Indiana University School of Medicine
2021
Chengdu Military General Hospital
2010-2017
Kunming General Hospital of Chengdu Military Command
2010-2013
This study revealed that EGCG attenuated AP-induced lung injury <italic>via</italic> suppressing NLRP3 inflammasome activation. The mtROS-scavenging activity enabled to impair signaling by inhibiting the generation of ox-mtDNA and its binding NLRP3.
Oxidative stress and inflammation play important roles in the progression from simple fatty liver to non-alcoholic steatohepatitis (NASH). The aim of this work was investigate whether treatment with hydrogen sulfide (H2 S) prevented NASH rats through abating oxidative suppressing inflammation.A methionine-choline-deficient (MCD) diet rat model prepared. Rats were divided into three experimental groups fed for 8 weeks as follows: (i) control rats; (ii) MCD-diet-fed (iii) treated NaHS...
Increasing evidence has demonstrated that reactive oxygen species (ROS) induces oxidative stress and plays a crucial role in the pathogenesis of acute pancreatitis (AP). Hydrogen-rich saline (HRS), well-known ROS scavenger, been shown to possess therapeutic benefit on AP many animal experiments. Recent findings have indicated NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome, an intracellular multiprotein complex required for maturation interleukin- (IL-) 1β, may...
Background: This study aimed to investigate whether exogenous hydrogen sulfide (H2S) can protect the RAW264.7 macrophages against inflammation induced by free fatty acids (FFA) blunting NLRP3 inflammasome activation via a specific TLR4/NF-κB pathway. Methods: were exposed increasing concentrations of FFA for up 3 days induce FFA-induced inflammation. The cells pretreated with NaHS (a donor H2S) before exposure FFA. Cell viability, cell apoptosis, TLR4, NF-κB, inflammasome, IL-1β, IL-18 and...
Pancreatitis induced by hypertriglyceridemia (HTG) has gained much attention. However, very limited numbers of studies have focused on the clinical significance TG elevation in non-HTG pancreatitis, such as acute biliary pancreatitis (ABP). This study aimed to significances triglyceride (TG) patients with ABP. We retrospectively analyzed a total 426 ABP cases our research center. According highest level within 72 h disease onset, were divided into normal group and an elevated group....
BACKGROUND Currently, little evidence exists to support whether the therapeutic approaches for treating ordinary acute pancreatitis (AP) are effective in trauma-induced pancreatitis. Hydrogen-rich (H2) saline is an antioxidant treatment capable of ameliorating severity L-arginine-induced AP. In this study, we attempted validate its protective role against traumatic (TP). METHODS A previously established experimental rat model TP was generated by controlled delivery high pressure air impact....
Background High mobility group box 1 (HMGB1) plays important roles in a large variety of diseases; glycyrrhizin (GL) is recognized as an HMGB1 inhibitor. However, few studies have focused on whether can potentially improve the outcome traumatic pancreatitis (TP) by inhibiting HMGB1. Methods A total 60 male Wistar rats were randomly divided into three groups (n = 20 each): Control group, TP and TP-GL group. Pancreatic trauma was established with custom-made biological impact machine-III, GL...
Increasing evidence has demonstrated that Toll-like receptor 4 (TLR4) -mediated systemic inflammatory response syndrome accompanied by multiple organ failure, is one of the most common causes death in patients with severe acute pancreatitis. Recent reports have revealed heparan sulphate (HS) proteoglycan, a component extracellular matrices, potentiates activation intracellular pro-inflammatory responses via TLR4, contributing to aggravation However, little known about participants...
Severe acute pancreatitis (SAP) is the most serious type of with high morbidity and mortality. The underlying mechanism behind SAP pathogenesis complex remains elusive. Circular RNAs (circRNAs) are emerging as vital regulators gene expression in various diseases by sponging microRNAs (miRNAs). However, roles circRNAs pathophysiology remain unknown. In present study, next-generation RNA sequencing was utilized to identify circRNA transcripts pancreatic tissues from three mice matched normal...
Inflammation and septic shock due to endotoxins from Gram-negative bacteria infection continue pose significant challenges human healthcare. It is, therefore, necessary develop therapeutic strategies targeting endotoxins, such as lipopolysaccharide (LPS), prevent their potentially systemic effects. Pathogenesis involves LPS binding the host LPS-binding protein (LBP), causing detrimental downstream signaling cascades. Our previous study showed that CLP-19, a synthetic peptide derived Limulus...
To explore the effect of delayed cord clamping on preterm infants.A retrospective analysis was conducted using clinical data 163 infants with a gestational age 34-36 weeks + 6 who were admitted to neonatology department within 2 hours after birth. The blood routine examination indices and at 3-5 days birth, biochemical arterial gas (ABG) hemoglobin level 5-6 months birth compared between early (ECC) group (DCC) group.Compared ECC group, DCC had significantly higher venous levels red cells,...
Broomcorn millet (Panicum miliaceum L.) is a crop with good ability to adapt the environment. Over 8800 accessions have been collected in national gene bank of China. The huge quantity germplasms made it difficult for analysis and evaluation. Although broomcorn core collection (CC) comprising 780 was established, number still too large researchers explore depth. In this study, genetic diversity 634 from analyzed based on SSR markers. A mini-core (MC) containing 256 extracted. accounted less...
Purpose. This study aimed to investigate the therapeutic potential of hydrogen-rich saline on pancreatic ischemia/reperfusion (I/R) injury in rats. Methods. Eighty heterotopic pancreas transplantations (HPT) were performed syngenic The receptors randomized blindly into following three groups: HPT group and two groups that underwent transplantation administration (HS, >0.6 mM, 6 mL/kg) or normal (NS, via tail vein at beginning reperfusion (HPT + HS group, NS group). Samples from blood...
Abstract Background Annular pancreas (AP) concurrent with pancreaticobiliary maljunction (PBMJ), an unusual coexisted congenital anomaly, often presented symptoms and subjected surgical treatment at the early age of life. We reported first adult case AP PBMJ until his twenties, performed a literature review to analyze clinicopathological features such cases comparing its pediatric counterpart. Case presentation The main clinical this were abdominal pain increased levels plasma amylase as...
Iatrogenic biliary stricture (IBS) is a disastrous complication of cholecystectomy. Although the endoscopic treatments are well accepted as initial attempts for IBS, surgical hepaticojejunostomy (HJ) often necessary considerable proportion patients. However, anastomotic after HJ also occurs.In present study, new procedure, progressive balloon dilation following (HJPBD), was designed and utilized in IBS treatment. We retrospectively compared HJPBD with traditional term outcomes when used...