A5101408461- Mangiferin and Mango Extracts
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Disease Mechanisms and Treatments
- Natural Antidiabetic Agents Studies
- Inflammasome and immune disorders
- RNA modifications and cancer
- Fungal Plant Pathogen Control
- Cancer-related molecular mechanisms research
- High Altitude and Hypoxia
- Adipokines, Inflammation, and Metabolic Diseases
- RNA Research and Splicing
- Plant Pathogens and Fungal Diseases
- Plant-Microbe Interactions and Immunity
- Liver Disease Diagnosis and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Hydrogen's biological and therapeutic effects
- Contact Dermatitis and Allergies
- Allergic Rhinitis and Sensitization
- Synthesis of Indole Derivatives
- RNA regulation and disease
- Prion Diseases and Protein Misfolding
- Metastasis and carcinoma case studies
- Virus-based gene therapy research
- Greenhouse Technology and Climate Control
- HIV Research and Treatment
Chengdu Third People's Hospital
2023-2025
Ningbo University
2025
Shihezi University
2024
Northwest A&F University
2010-2023
Chengdu Military General Hospital
2012-2021
Southwest Jiaotong University
2021
Qingdao Municipal Hospital
2010-2020
NorthShore University HealthSystem
2020
Qingdao University
2010-2020
University of British Columbia
2015
Given the importance of aggregation advanced glycation end products (AGEs) and cardiac inflammation in onset progression diabetic cardiomyopathy (DCM), our objective this study was to demonstrate cardioprotective effect mangiferin, an antidiabetic anti-inflammatory agent, on rat model. The DCM model established by a high-fat diet low dose streptozotocin. rats were treated orally with mangiferin (20 mg/kg) for 16 weeks. Serum left ventricular myocardium collected determination inflammatory...
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the interactions between multiple genetic and environmental factors. The pathogenesis of AD still not completely clear. Steroid topical therapy has severe side effects for symptoms new therapeutic options are urgently needed. Ferulic acid (FA) novel natural dietary polyphenol with anti-oxidative anti-inflammatory effects.Methods: FA was assessed in BALB/c mice AD-like lesions resulted from repetitive...
Background: Dietary sugar intake has been implicated in the development of metabolic dysfunction, chronic inflammation, and immune contributing to pathogenesis various diseases. This study aimed investigate associations between dietary total simple glycemic markers, lipid profile, serum levels high-sensitivity C-reactive protein (hs-CRP), adenosine deaminase activity (ADA), among semi-professional football players. Methods: A cross-sectional was conducted 108 sugars assessed using validated...
Increasing evidence has demonstrated that reactive oxygen species (ROS) induces oxidative stress and plays a crucial role in the pathogenesis of acute pancreatitis (AP). Hydrogen-rich saline (HRS), well-known ROS scavenger, been shown to possess therapeutic benefit on AP many animal experiments. Recent findings have indicated NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome, an intracellular multiprotein complex required for maturation interleukin- (IL-) 1β, may...
Diabetic cardiomyopathy (DCM) is one of the most common complications diabetes without effective treatment options. Its pathogenesis complex and remains unclear. Long non-coding RNA (lncRNA) MIAT allele has been reported to be enriched in DCM patients activate a pyroptosis program hypoxia-induced H9c2 cells. Thus, whether played role clarified. In study, expression was found elevated serum diabetic patients, as well high-glucose induced cardiomyocytes mice. Further, levels CASP1 correlation...
Abstract RNA-binding proteins (RBPs) are a class of that primarily function by interacting with different types RNAs and play critical role in regulating the transcription translation cancer-related genes. However, their progression hepatocellular carcinoma (HCC) remains unclear. In this study, we analyzed RNA sequencing data corresponding clinical information patients HCC to screen for prognostic RBPs. Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) was identified as an...
The purpose of this study was to investigate the cardioprotective effect mangiferin on diabetic cardiomyopathy (DCM). DCM model induced by a high-fat diet and low dose streptozotocin. We evaluated characteristics serial echocardiography, electron microscopy, histopathologic analysis cardiomyocyte fibrosis area, Western blot matrix metalloproteinase-2 (MMP-2) MMP-9 expression. Rats with showed severe left ventricular dysfunction cardiac fibrosis. Mangiferin mitigated prevented accumulation...
Yu Botao, Jie Ma, Wenjing Xiao, Qingyu Xiang, Kaihua Fan, Jun Hou, Juan Wu, and Weihua Jing. Protective effect of ginkgolide B on high altitude cerebral edema rats. High Alt Med Biol 14:61–64, 2013.—Ginkgolide (GB) is one the ginkgolides isolated from leaves Ginkgo biloba tree. The aim this study was to investigate whether GB has a protective (HACE) HACE induced by hypobaric hypoxia exposure for 24 hours in an animal decompression chamber with pressure 267 mmHg simulate 8000 m. Before...
Homeobox C6 (HOXC6) is a transcription factor that plays an important role in the development of several cancers. However, it unknown whether HOXC6 regulates cervical cancer progression. In this study, we used quantitative PCR and Western blots to demonstrate overexpression associated with These results are also supported by public RNA-seq data showing correlated poor patient survival. vitro vivo experiments revealed enhanced expression cell proliferation, cycle progression, anchorage colony...
Mangiferin functions as a perfect anti-oxidative compound in the diabetic heart, however, exact mechanism remains to be elucidated. Here, we show cardioprotective effect of mangiferin under high glucose-induced cardiotoxic condition mainly contributed enhanced autophagy via suppressing mTORC1 downstream signal transduction. Primary neonatal rat cardiomyocytes were cultured detect myocytes injury, autophagy, and related transduction different doses glucose treatment. High (30 mM) reduced...
Coxsackievirus B3 (CVB3), an important human causative pathogen for viral myocarditis, pancreatitis, and meningitis, has evolved different strategies to manipulate the host signaling machinery ensure successful infection. We previously revealed a crucial role ERK1/2 pathway in regulating infectivity. However, detail mechanism remains largely unknown. Grb2-associated binder 1 (GAB1) is docking protein responsible intracellular assembly transduction. In this study, we demonstrated that GAB1...
The purpose of this study was to clarify the protective role mangiferin on postinfarction myocardial remodeling and potential mechanisms. infarction (MI) model established by ligating left anterior descending coronary artery. Cardiac function, apoptosis fibrosis, serum tumor necrosis factor-α (TNF-α) phosphorylated p38 mitogen-activated protein kinase (MAPK) were examined echocardiography, histological staining, ELISA Western blot, respectively. Mangiferin attenuated MI prevented development...
In this study, we combined the dipeptidyl peptidase-4 inhibitor sitagliptin with antidiabetic drug mangiferin to examine effects on active glucagon-like peptide-1 (GLP-1) and glucose tolerance in streptozotocin-diabetic rats. Active GLP-1 levels were measured by an ELISA kit. Insulin RIA Islet morphology was determined double immunolabeling. Sitagliptin (1 mg/kg) or (20 single treatment improved during oral test. addition, combination therapy increase plasma insulin level levels. Islets from...
Abstract An asymmetric Friedel–Crafts alkylation of indole with in situ generated indol‐2‐one from functionalized 3‐bromooxinidole catalyzed by chiral N,N’ ‐dioxide/Ni(BF 4 ) 2 has been developed. This protocol provides an efficient route to stereoselective construction a series 3‐substituted 3’‐indolyloxindoles bearing quaternary carbon center excellent yields and enantioselectivities (up 99 % ee). In addition, the conversion resulted 3’‐indolyloxindole key intermediate for formal synthesis...