A5101567928- Hydrogen's biological and therapeutic effects
- Biomarkers in Disease Mechanisms
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Orthopaedic implants and arthroplasty
Soochow University
2021
Second Affiliated Hospital of Soochow University
2021
Chengdu Military General Hospital
2014
Increasing evidence has demonstrated that reactive oxygen species (ROS) induces oxidative stress and plays a crucial role in the pathogenesis of acute pancreatitis (AP). Hydrogen-rich saline (HRS), well-known ROS scavenger, been shown to possess therapeutic benefit on AP many animal experiments. Recent findings have indicated NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome, an intracellular multiprotein complex required for maturation interleukin- (IL-) 1β, may...
Lysyl oxidase (LOX) has been identified to modulate osteoclast activity, so we explored the role of LOXG473A, highest frequency single nucleotide polymorphism in LOX, formation and its potential relationship autophagy.The ability LOX mutant, promote autophagy was evaluated pre-osteoclast cell line RAW264.7. Furthermore, autophagy-related protein expression autophagosomes were detected by western blot electron microscopy, respectively. Simultaneously, resorption also using TRAP staining assay...