A5100662148- Lung Cancer Treatments and Mutations
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- S100 Proteins and Annexins
- Cytokine Signaling Pathways and Interactions
- Animal Virus Infections Studies
- Cancer Cells and Metastasis
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- Genomics, phytochemicals, and oxidative stress
- Cancer Immunotherapy and Biomarkers
- Natural product bioactivities and synthesis
- Animal Disease Management and Epidemiology
- RNA Interference and Gene Delivery
- Cell Adhesion Molecules Research
- Nanoparticle-Based Drug Delivery
- Vitamin C and Antioxidants Research
- Nanoplatforms for cancer theranostics
- Hepatitis B Virus Studies
- Cancer Mechanisms and Therapy
- Glutathione Transferases and Polymorphisms
- Immune cells in cancer
- Immune Cell Function and Interaction
- Pregnancy and preeclampsia studies
- Glioma Diagnosis and Treatment
Army Medical University
2013-2025
Daping Hospital
2007-2025
Army Medical College
2020-2024
Capital Medical University
2023
Weifang People's Hospital
2023
Beijing Tongren Hospital
2023
Affiliated Hospital of Nantong University
2022
Nantong University
2022
Roswell Park Comprehensive Cancer Center
2020-2022
Chongqing University
2019
Abstract Atherosclerosis remains the leading cause of a broad spectrum deadliest cardiovascular diseases. MicroRNA‐33 is new therapeutic target for atherosclerosis due to its diverse functions. However, it great challenge in clinical translation nucleic acid‐based microRNA‐targeting therapeutics. Considering lesional acidosis, herein cyclodextrin‐derived pH‐responsive and integrin‐targeting nanoparticles containing an antisense oligonucleotide against microRNA‐33 (anti‐miR33) are engineered...
OBJECTIVE CXCR4 is implicated in the growth, metastasis, and angiogenesis of malignant tumors. We investigated potential role human gliomas. METHODS The expression messenger ribonucleic acid protein by glioma cell lines was examined reverse-transcriptase polymerase chain reaction immunocytochemistry analysis. Tumor chemotaxis production vascular endothelial growth factor induced ligand SDF-1β were measured. Xenograft models used for evaluation tumorigenesis. xenografted tumors primary...
Malfunctioned gap junctional intercellular communication (GJIC) has been thought associated with malignant transformation of normal cells. However, the role GJIC-related proteins such as connexins in sustaining behavior cancer stem cells remains unclear. In this study, we obtained tumorspheres formed by glioma (GSCs) and adherent GSCs then examined their GJIC. All showed reduced GJIC, differentiated had more junction-like structures than GSCs. expressed very low level connexins, Cx43...
Local immunosuppression remains a critical problem that limits clinically meaningful response to checkpoint inhibition in patients with head and neck cancer. Here, we assessed the impact of MDSC elimination on responses CTLA-4 inhibition.Murine syngeneic carcinoma immune infiltrates were characterized by flow cytometry. Granulocytic MDSCs (gMDSCs) depleted T-lymphocyte antigen-specific measured. Tumor-bearing mice treated depletion blockade. Immune signatures within human HNSCC datasets from...
Glycogen synthase kinase-3β (GSK-3β) acts as a negative regulator of NF-E2 related factor 2 (Nrf2) by inducing Nrf2 degradation and nuclear export. Our previous study demonstrated that the flavonoid hyperoside elicits cytoprotection against oxidative stress activating Keap1-Nrf2-ARE signaling pathway, thus increasing expression antioxidant enzymes, such heme oxygenase-1 (HO-1), superoxide dismutase (SOD) catalase. However, role GSK-3β in hyperoside-mediated activation is unclear. Here, we...
Cancer stem cells (CSCs) are highly proliferative and tumorigenic, which contributes to chemotherapy resistance tumor occurrence. CSCs specific therapy may achieve excellent therapeutic effects, especially the drug-resistant tumors. In this study, we developed a kind of targeting nanoparticle system based on cationic albumin functionalized with hyaluronic acid (HA) target CD44 overexpressed CSCs. All-trans-retinoic (ATRA) was encapsulated in nanoparticles ultrahigh encapsulation efficiency...
Eriodictyol (Eri) is a widely distributed flavonoid compound. We explored the effect of Eri on non-alcoholic fatty liver disease (NAFLD) and underlying mechanism. reduced hepatic lipid accumulation alanine aminotransferase, aspartate cholesterol, triglyceride levels in high-fat diet-induced NAFLD mice. Proteomics analysis showed that regulated oxidative stress- autophagy-related signaling pathways. treatment upregulated MAP1LC3 (LC3)II/I, nuclear factor E2-related (Nrf2), heme oxygenase 1...
To evaluate the influence of various distributions bone cement on clinical efficacy percutaneous kyphoplasty (PKP) in treating osteoporotic vertebrae compression fractures.A total 201 OVCF patients (30 males and 171 females) who received PKP treatment our hospital were enrolled this study. According to characteristic distribution, divided into 2 groups: group A ("H" shaped group), filling pattern vertebral body briquettes connected with / without bridge; B ("O" was a complete crumb any...
Hyperoside (Hyp) is a flavonoid substance extracted from plants, which has the functions of anti-cancer, anti-inflammatory, and anti-oxidation. In previous study, we found that Hyp reduced injury rat retinal vascular endothelial cells (RVECs) induced by H2O2.In present research, evaluated protective effect on pathological damage retina caused high glucose diabetes mellitus (DM) in vitro vivo experiments. The cell viability, oxidative stress level, apoptosis RVECs was assessed.Hyp...
The present study aimed to explore the effect of Saikosaponin D (SSD) and its underlying mechanism on apoptosis autophagy in human breast cancer MDA‑MB‑231 cells. MTT assay, flow cytometry, western blotting confocal fluorescence microscopy detection were employed. SSD, a kind triterpenoid saponins extracted from Radix bupleuri, has been demonstrated have effects anti‑inflammatory, antioxidative anticancer can regulate autophagy. revealed that SSD induced through activation p38...
Hyperoside, isolated from Drosera rotundifolia, Cuscuta chinensis seeds, or St John's wort, originally showed to possess an antifungal and antibacterial activity, while recently the protective effects against oxidative stress-induced liver injury. This study investigated such a effect of hyperoside underlying molecular mechanisms in vitro carbon tetrachloride (CCl4)-injured rat livers. The data that was able prevent morphological changes CCl4-induced Hyperoside reversed decrease superoxidase...
To explore the effect of resveratrol in premature senescence and reveal its anti-premature mechanisms through network pharmacology.In this study, H2O2-induced bone marrow mesenchymal stem cells (BMMSCs) model is applied. Cell counting kit-8 assay, β-galactosidase staining flow cytometry are conducted to detect proliferation, apoptosis BMMSCs. Bioinformatics analyses used screen validate molecular targets acting on senescence. Dual-luciferase reporter assay verify interaction between v-rel...
Backgrounds/Aims: Preeclampsia was characterized by excessive thrombin generation in placentas and previous researches showed that could enhance soluble Fms-like tyrosine kinase 1 (sFlt-1) expression first trimester trophoblasts. However, the detailed mechanism for sFlt-1 over-production induced largely unknown. The purpose of this study to explore possible signaling pathway thrombin-induced production extravillous trophoblasts (EVT). Methods: An EVT cell line (HRT-8/SVneo) treated with...